舒血宁对不稳定型心绞痛患者CRP和MMP-9的影响
《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]
- 期数:
- 2014年第3期
- 页码:
- 293-295
- 栏目:
- 临床研究
- 出版日期:
- 2014-03-20
文章信息/Info
- Title:
- Influence of shuxuening on high-sensitivity C-reactive protein and matrix metalloproteinase-9 in patients with unstable angina pectoris
- Author(s):
- CHENG Jing lin; WAN Jun
- (Department of Emergency, Second Affiliated Hospital, Anhui Medical University, Hefei 230601, Anhui, China)
- 分类号:
- R541.4;R972
- DOI:
- -
- 文献标识码:
- A
- 摘要:
- 目的:观察经舒血宁治疗后，不稳定型心绞痛（unstable angina pectoris,UAP）患者体内高敏C反应蛋白（high sensitivity C-reactive protein,hs-CRP）和基质金属蛋白酶9(matrix metalloproteinase-9，MMP-9)水平的变化。方法:100例UAP患者随机分为试药组和对照组，各50例。对照组给于常规治疗，试药组在此基础上加用舒血宁30 ml溶于250 ml 50 g/L葡萄糖注射液中静脉滴注，1次/d，连续治疗两周。在入院时、入院后12 h、24 h、48 h、7 d及14 d抽取外周血，检测各组患者hs-CRP和MMP9表达水平变化。结果:两组UAP患者外周血hs-CRP水平在入院后均开始升高，于24 h达高峰，24 h后逐渐下降；两组MMP-9水平入院后12 h达高峰，后逐渐下降；与对照组相比，试药组hs-CRP和MMP-9水平在入院后12 h、24 h、48 h、7 d及14 d均显著降低。结论:舒血宁可显著降低UAP患者体内hs-CRP和MMP-9表达水平。
- Abstract:
- AIM:To investigate the risk factors of acute cerebral infarction in type H hypertensive patients in Tongchuan City. METHODS: A 1∶1 matched case-control study was conducted in 561 cases of confirmed acute cerebral infarction diagnosed in H type hypertensive patients in Tongchuan City. EPI-info (6.04) and SPSS (15) were used for the logistic regression analysis of single and multiple factors, and the adjusted odds ratio of each factor (OR) and 95% confidence limit (CI) were calculated. RESULTS: Single factor analysis found that hyperlipidemia, diabetes, high C-reactive protein, transient ischemic attack (TIA), obesity, smoking and alcoholism were related to acute cerebral infarction. Enalapril maleate and folic acid tablets reduced the risk of acute cerebral infarction in H type hypertensive patients. Multivariate analysis showed that diabetes, high C-reactive protein, severe carotid stenosis and TIA were the main risks of acute cerebral infarction in H type hypertensive patients. CONCLUSION: The independent risk factors in H type hypertensive patients are high C-reactive protein, diabetes, severe carotid stenosis and TIA. Enalapril maleate and folic acid tablets are protective factors.
参考文献/References
[1]Belalcazar LM,Reboussin DM,Haffner SM,et al.A 1-year lifestyle intervention for weight loss in individuals with type 2 diabetes reduces high C-reactive protein levels and identifies metabolic predictors of change:from the Look AHEAD (Action for Health in Diabetes) study[J].Diabetes Care,2011,33 (11):2297-2303.
[2]Emerging Risk Factors Collaboration,Kaptoge S,Di Angelantonio E,et al.C-reactive protein,fibrinogen, and cardiovascular disease prediction[J].N Enql J Med,2012,367(14):1310-1320.
[3]Timóteo AT,Miranda F,Feliciano J,et al.Influence of anthropometric variables in C reactive protein[J].Acta Med Port,2011,24(3):419-426.
[4]Rybakowski JK,Borkowska A,Skibinska M,et al.The-1562 C/T polymorphism of the matrix metalloproteinase-9 gene is not associated with cognitive performance in healthy participants[J].Psychiatr Genet,2009,19(5):277-278.
[5]Szulik M, Stabry?a-Deska J,Boidol J,et al.Echocardiography-based qualification and response assessment to cardiac resynchronisation therapy in patients with chronic heart failure The matrix metalloproteinase-9 substudy[J].Kardiol Pol,2011,69(10):1043-1051.
[6]张金山.冠心病患者血清MMP-9, IL-6、hs-CRP水平检测及分析[J].山东医药,2011, 51(23):42-43.
[7]Tonnesen MG,Smedly LA,Henson PM.Neutrophil-endothelial cell interactions.Modulation of neutrophil adhesiveness induced by complement fragments C5a and C5a des arg and formyl-methionyl-leucyl-phenylalanine in vitro [J].J Clin Inbest,1984,74(5):1581-1592.
[8]王红联,刘立杰,赵淑清.舒血宁注射液对急性脑梗死患者血清VEGF,vWF和MMP-9的影响[J].中国实验方剂学杂志,2013,19(10):343-345.
[9]刘 莉,李 鑫,刘 聪.舒血宁注射液治疗高脂血症及对C反应蛋白（CRP）影响的研究[J].中国中医药咨讯,2011,3(9):67-68.
备注/Memo
- 备注/Memo:
- 收稿日期：2013-06-07.
作者简介：程景林，副主任医师，博士生 Email：410643872@qq.com
常用功能
统计/Statistics
- 摘要浏览/Viewed720
- 评论/Comments
