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|本期目录/Table of Contents|

老年冠心病患者抑郁与血脂水平的关系

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2014年第4期
页码:
462-464
栏目:
临床研究
出版日期:
2014-04-25

文章信息/Info

Title:
Relationship between depression and lipid levels in elderly patients with coronary heart disease
作者:
孙翠峰1; 阿依吐尔汉·马合木提2; 古丽扎尔·买买提明1
（1.新疆医科大学第一附属医院干部病房内二科，新疆 乌鲁木齐830054；
2.伊利州友谊医院外科重症监护室，新疆 伊利 835200）
Author(s):
SUN Cui-feng1;  AYITUERHAN·Mahemut2;  GULIZHAER·Maimaitiming1
(1.Second Department of Cardiology, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, Xinjiang, China;
2.ICU, Friendship Hospital of Yili, Yili 835200, Xinjiang, China)
关键词:
老年人; 冠状动脉疾病; 抑郁; 血脂水平
Keywords:
elderly;  coronary disease;  depression;  lipid levels
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的:探讨老年冠心病患者抑郁与血脂水平之间的关系。方法： 采用病例对照研究方法，将老年冠心病患者168例按抑郁自评量表（SDS）及综合医院焦虑抑郁量表抑郁分表（HAD）评分分为冠心病伴抑郁组（抑郁组，87例）和冠心病不伴抑郁组（非抑郁组，81例）。测定所有研究对象的血清总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)和脂蛋白α（Lp（α））。结果： 抑郁组TG、LDL-C水平显著高于非抑郁组（P<0.01），而TC显著低于非抑郁组（P<0.01）。多元逐步回归分析，TC、TG、LDL-C是抑郁的影响因素。结论： 血脂的变化与抑郁情绪有关，伴有抑郁情绪的冠心病患者血脂异常更为明显。
Abstract:
AIM:To investigate the relationship between depression and lipid levels in elderly patients with coronary heart disease (CHD). METHODS: Data were collected for 168 elderly CHD patients and 50 healthy elderly volunteers (control group). According to the results of self-rating depression scale (SDS) and sublist of hospital anxiety and depression scale (HAD), the 168 elderly CHD patients were divided into two groups: CHD with depression group and CHD without depression group. Serum total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and lipoprotein α ［Lp(α)］ were tested. RESULTS: Significant difference was observed in serum TC, TG and LDL-C between CHD with depression group and CHD without depression group, in serum LDL-C between CHD with depression group and control group and in serum TC, TG and LDL-C between CHD with depression group and control group (all P<0.01). Stepwise multivariate regression analysis demonstrated that TC, TG and LDL-C markedly influenced depression. Multivariate logistic regression analysis showed that TC and LDL-C were independent risk factors for CHD in elderly patients. CONCLUSION: Changes of blood lipids are associated with depression, especially in patients with CHD. Depression and changes of lipid levels both promote the development of CHD.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期: 2013-10-16.基金项目：新疆维吾尔自治区自然科学基金项目资助(2011211A083) 通讯作者：古丽扎尔·买买提明，主任医师，主要从事老年冠心病与心理行为相关性的研究 Email：lilac40157@yahoo.com.cn 作者简介：孙翠峰，硕士生 Email： scf1021@126.com
更新日期/Last Update: 2014-05-06