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|本期目录/Table of Contents|

中性粒细胞与淋巴细胞比值与冠状动脉狭窄程度的关系

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2014年第5期
页码:
575-578
栏目:
临床研究
出版日期:
2014-05-25

文章信息/Info

Title:
Relationship between neutrophil to lymphocyte ratio and severity of coronary artery stenosis
作者:
张光宇1; 陈 明1; 余志敏1; 汪小丁2; 王智泉1
(武汉大学:1.中南医院心内科，湖北 武汉，430071，2.人民医院心内科，湖北 武汉 430060)
Author(s):
ZHANG Guang-yu1;  Chen Ming1;  YU Zhi-min1;  WANG Xiao-ding2;  WANG Zhi-quan1
(1.Department of Cardiology, Zhongnan Hospital, Wuhan University, Wuhan 430071, Hubei, China;
2.Department of Cardiology, Renmin Hospital, Wuhan University, Wuhan 430060, Hubei, China)
关键词:
中性粒细胞与淋巴细胞比值; 冠状动脉疾病; Gensini积分1
Keywords:
neutrophil to lymphocyte ratio;  coronary artery disease;  Gensini score
分类号:
R446.11
DOI:
-
文献标识码:
A
摘要:
目的:研究中性粒细胞与淋巴细胞比值(NLR)与冠状动脉狭窄程度的关系,探讨NLR对冠心病患者冠状动脉病变严重程度的预测作用。 方法： 219 例患者依据冠状动脉造影结果进行冠脉Gensini评分并根据其结果将其分为低分组(0~30分)142例和高分组(>30分)77 例，检测外周血白细胞分类计数并计算NLR,应用spss17.0 软件进行统计分析。结果： ①NLR在不同类型冠心病患者及冠脉正常患者之间存在差异(P<0.05)；②以冠脉Gensini积分将患者分组后，高分组NLR与低分组间差异有统计学意义(P<0.01),单因素及多因素Logistic回归分析显示NLR与年龄、高密度脂蛋白胆固醇均是高Gensini积分的独立危险因素；③受试者工作特征曲线(ROC曲线)显示NLR的曲线下面积为0.658(95%CI:0.583-0.733),且当NLR切值取2.385 时,其诊断效率最高,敏感性为64%,特异性为63%。结论： NLR是冠心病的独立危险因素,可作为预测冠状动脉狭窄程度的指标。
Abstract:
AIM:To investigate the association between neutrophil to lymphocyte ratio (NLR) and severity of coronary artery stenosis (CAS). METHODS: According to the results of coronary angiography, a total of 219 patients were divided into two groups according to Gensini scores: low score group (n=142) and high score group (n=77). RESULTS: NLR in acute coronary syndrome (ACS) group was higher than those in stable angina pectoris (SAP) group and NT group (P<0.05), and the NLR in high score group was higher than that in the low score group (P<0.01). A cut-off value of 2.385 for NLR predicted high Gensini score, with a sensitivity and specificity of 64% and 63%, respectively. Uni- and multivariate analyses showed that high levels of NLR, age and high-density lipoprotein were independent predictors of high Gensini score. CONCLUSION: Our study suggests that the NLR is an independent predictor of coronary heart disease and can be used to predict the severity of CAS.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2013-12-26.
基金项目：湖北省自然科学基金项目资助（2010cdb06003）
通讯作者：王智泉，副主任医师，主要从事冠心病临床与基础研究 Email:zgy690511128@gmail.com
作者简介：张光宇，硕士生 Email：690511128@qq.com
更新日期/Last Update: 2014-06-05