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|本期目录/Table of Contents|

miR-126与心血管疾病关系的研究进展

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2014年第6期
页码:
724-726733
栏目:
综述
出版日期:
2014-06-25

文章信息/Info

Title:
Current research and progress of miR-126 effects in cardiovascular diseases
作者:
李国达1; 刘衍宇2; 方凌燕2
（广东医学院：1.研究生院，2.第二附属医院心血管内科,广东 湛江 524003）
Author(s):
LI Gou-da1;  LIU Yan-yu2;  FANG Ling-yan2
(1.Graduate School, 2.Department of Cardiology, Second Affiliated Hospital, Guangdong Medical College, Zhanjiang 524003, Guangdong, China)
关键词:
microRNA-126; 高血压; 动脉粥样硬化; 冠状动脉疾病; 心力衰竭
Keywords:
microRNA-126;  hypertension;  atherosclerosis;  coronary disease;  heart failure
分类号:
R54
DOI:
-
文献标识码:
A
摘要:
微小核糖核酸（microRNAs，miRNA）是一类内源性高度保守的非编码小分子RNA，其可通过降解信使RNA并抑制其翻译在转录水平调控靶基因的表达，参与细胞生长、发育、分化和增殖等多个生命过程。MicroRNAs-126(miR-126) 是一种内皮特异性 miRNA，与高血压、动脉粥样硬化、冠心病、心力衰竭等心血管疾病密切相关。近期研究表明，miR-126能显著影响心血管疾病的发生、发展和疾病的预后。本文就miR-126与心血管疾病的关系进行综述。
Abstract:
MicroRNAs (miRNAs, miRNA) are a class of endogenous highly conserved, small, noncoding RNA molecules, which control the expression of genes at the post-transcriptional level through degradation of messenger RNA and inhibits its translation. They are involved in cell growth, development, differentiation, proliferation and other life processes. miR-126 is a kind of specific miRNA, which is closely related to hypertension, atherosclerosis, coronary heart disease, heart failure and other cardiovascular diseases. Recent studies have shown that miR-126 can significantly affect the incidence and development of cardiovascular diseases. More so, it can also influence the prognosis of cardiovascular diseases. In this paper, the relationship between miR-126 and cardiovascular diseases was reviewed.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2013-12-09.通讯作者：刘衍宇，主任医师,主要从事老年心脑血管疾病诊治研究Email：2822528480@qq.com
作者简介：李国达，硕士生Email：554576785@qq.com
更新日期/Last Update: 2014-07-10