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|本期目录/Table of Contents|

热休克蛋白47与PⅠCP在慢性心力衰竭患者中的相关性

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2015年第1期
页码:
45-047
栏目:
临床研究
出版日期:
2014-09-25

文章信息/Info

Title:
Correlation between heat shock protein 47 and pro-collagen type I C-terminal peptide in patients with chronic heart failure
作者:
田倪妮1; 2; 魏 玲1; 李宏键3; 陈 黔1; 倪茂娥4; 马 玲1; 林梦娇1; 2
(1.成都军区昆明总医院地方干部病房，云南 昆明 650032；
2.昆明医科大学研究生部，云南 昆明 650032；
3.云南省第一人民医院骨科，云南，昆明 650034；
4.云南省开远市人民医院儿科，云南 开远 661000)
Author(s):
TIAN Ni-ni1; 2;  WEI Ling1;  LI Hong-jian3;  CHEN Qian1;  NI Mao-e4;  MA Ling1;  LIN Meng-jiao1; 2
(1.Wards for Civilian Cadres, Kunming General Hospital, Chengdu Military Area Command, Kunming 650032, Yunnan, Chian;
2.Graduate School, Kunming Medical University, Kunming 650032, Yunnan, China;
3.Department of Orthopedics, Yunnan First People’s Hospital, Kunming 650034, Yunnan, China;
4.Department of Paediatrics, People’s Hospital of Kaiyuan City in Yunnan, Kaiyuan 661000, Yunnan, China)
关键词:
热休克蛋白47; 心力衰竭; 慢性; 心肌纤维化; 心室重构
Keywords:
heat shock protein 47;  chronic heart failure;  myocardial fibrosis;  ventricular remodeling
分类号:
R541.6
DOI:
-
文献标识码:
A
摘要:
目的:慢性心力衰竭（CHF）是一种慢性的，逐渐进展的临床综合征。研究热休克蛋白47(HSP47)与血清Ⅰ型胶原羧基端肽(PⅠCP)在CHF不同心功能分级中的表达及其相关性。方法： 将60名患者分为心功能Ⅰ级、心功能Ⅱ级、心功能Ⅲ级，采用ELISA测定患者血清中的HSP47的含量与PⅠCP的含量，并研究两者与CHF的相关性。结果： 与心功能1级组比较，心功能Ⅱ级组PⅠCP含量显著增高（P<0.01），且心功能Ⅲ级组较心功能Ⅱ级组PⅠCP含量显著增高（P<0.01），且血清HSP47含量与PⅠCP含量呈正相关。结论： CHF患者存在心肌纤维化及左心室扩大，两者呈正相关关系，提示CHF患者存在心室结构重构，心肌纤维化在心室重构中起重要作用。CHF患者HSP47和PⅠCP显著升高，且呈显著正相关。
Abstract:
AIM:To study the correlation between heat shock protein 47 and pro-collagen type I C-terminal peptide (PICP) in patients with different classifications of chronic heart failure (CHF). METHODS: Sixty patients were equally divided into three groups: NYHA I group, NYHA II group, and NYHA III group (n=20 in each group). Expressions of HSP47 and PICP in serum were measured by enzyme-linked immunosorbent assay (ELISA). RESULTS: Serum concentration of PICP in the NYHA II group was significantly higher than in the NYHA I group and the concentration of serum PICP in NYHA III group was significantly higher than in the NYHA II group (both P<0.05). A positive correlation was found between expression of HSP47 and PICP. CONCLUSION: Myocardial fibrosis and left ventricular diameter are positively correlated, suggesting that myocardial fibrosis plays an important role in ventricular remodeling. HSP47 and PICP in blood-serum have a significantly positive correlation in patients with CHF.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2014-04-01.
通讯作者：魏玲，主任医师，主要从事心血管疾病研究Email:weilling43@yahoo.com.cn
作者简介：田倪妮，住院医师，硕士生Email:70326943@qq.com
更新日期/Last Update: 2015-01-20