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|本期目录/Table of Contents|

eNOS/NO 信号通路与心血管疾病关系的研究进展

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2015年第1期
页码:
95-098
栏目:
综述
出版日期:
2014-09-25

文章信息/Info

Title:
Research progress of endothelial nitric oxide synthase/nitric oxide signal pathway in cardiovascular diseases
作者:
刘 丹; 王蓓蕾; 张黎明
(第二军医大学海医系海洋生物技术教研室，上海 200433)
Author(s):
LIU Dan;  WANG Bei-lei;  ZHANG Li-ming
(Department of Marine Biotechnology, Second Military Medical University, Shanghai 200433, China)
关键词:
一氧化氮; 内皮型一氧化氮合酶; 信号通路; 心血管疾病
Keywords:
nitric oxide;  endothelial nitric oxide synthase;  signal pathway;  cardiovascular diseases
分类号:
R54
DOI:
-
文献标识码:
A
摘要:
一氧化氮（nitric oxide，NO）作为一种信号分子，在生理活动中起着重要作用，包括血压调节、血管张力维持、免疫系统调控等，尤其在心血管系统中发挥重要作用。NO产生异常是多种心血管疾病的诱因。内皮型一氧化氮合酶（endothelial nitric oxide synthase，eNOS）作为诱导合成NO的限速酶，主要在血管壁的调节中发挥重要作用，因此，其与心血管的正常生理活动密切相关。本文综述了eNOS的基本结构与功能、NO的理化性质，以及eNOS/NO信号通路与心血管系统疾病的关系。
Abstract:
Nitric oxide (NO), a key signaling molecule, plays an important role in physiological activities including blood pressure regulation, vascular tone maintenance and immune system regulation. In the cardiovascular system, abnormal productivity of NO is the incentive for many cardiovascular diseases. As a rate-limiting enzyme of NO, endothelial nitric oxide synthase (eNOS) is important in the regulation of blood vessel walls. Therefore, eNOS is closely related to normal cardiovascular functions. In this article we briefly describe the basic structure and functions of eNOS as well as the physico-chemical properties of NO. We then focused on the relationship between eNOS/NO signaling pathway and cardiovascular diseases such as endothelial dysfunction-related diseases, vascular remodeling, and ischemic cardiovascular diseases.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2014-03-21.
基金项目：国家自然科学基金项目资助（41176126，81370833）
通讯作者：张黎明，教授，主要从事海洋生物伤防治与资源开发研究Email：lmzhang1969@163.com
作者简介：刘丹，硕士生Email：liudanzhongyao@163.com
更新日期/Last Update: 2015-01-20