«上一篇/Previous Article|本期目录/Table of Contents|下一篇/Next Article»

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:

2015年第2期

页码:

229-232

栏目:

综述

出版日期:

2014-10-25

文章信息/Info

Title:

Role of pigment epithelium-derived factor in cardiovascular diseases

作者:

孔 静¹; 郭辰峻¹; 于 海¹; 梁宏亮²; 侯慧媛³

(第四军医大学：1.学员一旅二十四连，陕西 西安 710032，2.西京医院心血管外科，陕西 西安 710032，3.西京医院眼科，陕西 西安 710032)

Author(s):

KONG Jing¹;  GUO Chen-jun¹;  YU Hai¹;  LIANG Hong-liang²;  HOU Hui-yuan³

(1.Company 24, First Brigade of Cadets, 2.Department of Cardiovascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an 710032；
3.Department of Ophthalmology, Xijing Hospital, the Fourth Military Medical University,Xi’an 710032)

关键词:

色素上皮衍生因子; 心血管; 动脉粥样硬化; 代谢综合征; 治疗靶点

Keywords:

PEDF;  metabolic syndrome;  arteriosclerosis;  therapeutic target

分类号:

Q543

DOI:

-

文献标识码:

A

摘要:

色素上皮衍生因子（PEDF）生物学功能复杂，既往研究证明其在眼部与神经系统的生理稳态和病理过程中扮演重要角色。近年发现PEDF在心血管系统与脂肪组织表达量高，PEDF与代谢综合征、动脉粥样硬化、高血压、心衰与心肌梗死等心血管疾病关系密切但机制尚未完全阐明，它可能在这些疾病的病理过程中发挥重要作用。PEDF有望成为一个新的有效的治疗心血管疾病的靶点和疾病预测分子。

Abstract:

Pigment epithelium-derived factor (PEDF) was first identified in conditioned medium from fetal human retinal pigment epithelium cells as a factor with potent neuronal differentiation activity. As a secreted glycoprotein, PEDF attracts wide attention for its various biological functions. In recent years we have found that PEDF has high expression in the cardiovascular system. Both laboratory and clinical research show PEDF is closely related to metabolic syndrome, atherosclerosis, hypertension and heart failure. PEDF may be an effective therapeutic target or a predicting factor in cardiovascular diseases.

参考文献/References

[1]Tombran-Tink J,Johnson LV.Neuronal differentiation of retinoblastoma cells induced by medium conditioned by human RPE cells[J].Invest Ophthalmol Vis Sci,1989,30(8):1700-1707.
[2]Tombran-Tink J,Chader GG,Johnson LV,et al.PEDF:a pigment epithelium-derived factor with potent neuronal differentiative activity[J].Exp Eye Res,1991,53(3):411-414.
[3]Drevon CA.Fatty acids and expression of adipokines[J].Biochim Biophys Acta,2005,1740(2):287-292.
[4]Petersen SV,Valnickova Z,Enghild JJ.Pigment-epithelium-derived factor(PEDF)occurs at a physiologically relevant concentration in human blood: purification and characterization[J].Biochem J,2003,374(Pt 1):199-206.
[5]Rychli K,Kaun C,Hohensinner PJ,et al.The anti-angiogenic factor PEDF is present in the human heart and is regulated by anoxia in cardiac myocytes and fibroblasts[J].J Cell Mol Med,2010,14(1-2):198-205.
[6]Stratikos E,Alberdi E,Gettins PG,et al.Recombinant human pigment epithelium-derived factor(PEDF):characterization of PEDF overexpressed and secreted by eukaryotic cells[J].Protein Sci,1996,5(12):2575-2582.
[7]Becerra SP,Perez-Mediavilla LA,Weldon JE,et al.Pigment epithelium-derived factor binds to hyaluronan. Mapping of a hyaluronan binding site[J].J Biol Chem,2008,283(48):33310-33320.
[8]Yamagishi S,Matsui T,Nakamura K.Atheroprotective properties of pigment epithelium-derived factor(PEDF)in cardiometabolic disorders[J].Curr Pharm Des,2009,15(9):1027-1033.
[9]Tahara N,Yamagishi S,Tahara A,et al.Serum level of pigment epithelium-derived factor is a marker of atherosclerosis in humans[J].Atherosclerosis,2011,219(1):311-315.
[10]Wang F,Ma X,Zhou M,Pan X,et al.Serum pigment epithelium-derived factor levels are independently correlated with the presence of coronary artery disease[J].Cardiovasc Diabetol,2013,12:56.
[11]Takenaka K,Yamagishi S,Matsui T,et al.Pigment epithelium-derived factor(PEDF)administration inhibits occlusive thrombus formation in rats:a possible participation of reduced intraplatelet PEDF in thrombosis of acute coronary syndromes[J].Atherosclerosis,2008,197(1):25-33.
[12]Yamagishi S,Matsui T,Nakamura K,et al.Administration of pigment epithelium-derived factor prolongs bleeding time by suppressing plasminogen activator inhibitor-1 activity and platelet aggregation in rats[J].Clin Exp Med,2009,9(1):73-76.
[13]Ueda S,Yamagishi S,Matsui T,et al.Administration of pigment epithelium-derived factor inhibits left ventricular remodeling and improves cardiac function in rats with acute myocardial infarction[J].Am J Pathol,2011,178(2):591-598.
[14]Liang H,Hou H,Yi W,et al.Increased expression of pigment epithelium-derived factor in aged mesenchymal stem cells impairs their therapeutic efficacy for attenuating myocardial infarction injury[J].Eur Heart J,2013,34(22):1681-1690.
[15]Sabater M,Moreno-Navarrete JM,Ortega FJ,et al.Circulating pigment epithelium-derived factor levels are associated with insulin resistance and decrease after weight loss[J].J Clin Endocrinol Metab,2010,95(10):4720-4728.
[16]Miyagishi D,Ohno-Matsui K,Amagasa T,et al.Regulation of the expression of pigment epithelium-derived factor, an anti-angiogenic factor in human oral squamous cell carcinoma cell lines[J].Cancer Lett,2003,196(1):77-85.
[17]Famulla S,Lamers D,Hartwig S,et al.Pigment epithelium-derived factor(PEDF)is one of the most abundant proteins secreted by human adipocytes and induces insulin resistance and inflammatory signaling in muscle and fat cells[J].Int J Obes(Lond),2011,35(6):762-772.
[18]Wang P,Smit E,Brouwers MC,et al.Plasma pigment epithelium-derived factor is positively associated with obesity in Caucasian subjects, in particular with the visceral fat depot[J].Eur J Endocrinol,2008,159(6):713-718.
[19]Yamagishi S,Adachi H,Abe A,et al.Elevated serum levels of pigment epithelium-derived factor in the metabolic syndrome[J].J Clin Endocrinol Metab,2006,91(6):2447-2450.
[20]Tahara N,Yamagishi S,Tahara A,et al.Serum levels of pigment epithelium-derived factor,a novel marker of insulin resistance, are independently associated with fasting apolipoprotein B48 levels in humans[J].Clin Biochem,2012,45(16-17):1404-1408.
[21]Chen C,Tso AW,Law LS,et al.Plasma level of pigment epithelium-derived factor is independently associated with the development of the metabolic syndrome in Chinese men:a 10-year prospective study[J].J Clin Endocrinol Metab,2010,95(11):5074-5081.
[22]Stejskal D,Karpísek M,Svesták M,et al.Pigment epithelium-derived factor as a new marker of metabolic syndrome in Caucasian population[J].J Clin Lab Anal,2010,24(1):17-19.
[23]Chen C,Tso AW,Cheung BM,et al.Plasma concentration of pigment epithelium-derived factor is closely associated with blood pressure and predicts incident hypertension in Chinese:a 10-year prospective study[J].Clin Endocrinol(Oxf),2012,76(4):506-513.
[24]Rychli K,Niessner A.Prognostic value of pigment Epithelium-Derived factor in advanced heart failure patients[J].Chest,2010,138(3):656-664.

备注/Memo

备注/Memo:

收稿日期：2014-06-12.
通讯作者：梁宏亮，主治医师，主要从事缺血性心脏病的基础研究 Email：dr.lianghongliang@hotmail.com 共同
通讯作者：侯慧媛，主治医师，主要从事PEDF与新生血管相关研究 Email:hhywyyx@163.com
作者简介：孔静，本科生 Email：498234722@qq.com

常用功能

更新日期/Last Update: 2014-11-18