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|本期目录/Table of Contents|

黄连素干预对代谢综合征及心脑血管疾病影响

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2015年第3期
页码:
348-352
栏目:
综述
出版日期:
2015-01-11

文章信息/Info

Title:
Advances on berberine in the control of metabolic syndrome and cardio/cerebrovascular disease
作者:
吴林根1; 王 燕2; 朱 峥3; 李方都4; 刘 兵5; 张兴儒6
（上海市普陀区利群医院：1.吴林根代谢综合征工作室；
2.药剂科，3.呼吸科，4.核医学科，5.内科，6.眼科 上海 200333）
Author(s):
WU Lin-gen1;  WANG Yan2;  ZHU Zheng3;  LI Fang-du4;  LIU Bing5;  ZHANG Xing-ru6
(1.Dr. L. G. Wu Metabolic Syndrome Studio, 2.Department of Pharmacy, 3.Department of Respiration, 4.Department of Nuclear Medicine, 5.Department of Internal Medicine, 6.Department of Ophthalmology, Liqun Hospital of Putuo District, Shanghai 200333, China)
关键词:
黄连素; 代谢综合征; 降血糖; 降血脂
Keywords:
berberine;  metabolic syndrome;  hypoglycemic effect;  hypolipidemic effect
分类号:
R543
DOI:
-
文献标识码:
A
摘要:
代谢综合征是以肥胖为中心，高血压、高血糖、高血脂、高胰岛素血症聚集于个体的临床征候群，是一组代谢起源的相互关联的危险因素的集合。黄连素化学通用名盐酸小檗碱，是存在于中药黄连等6科植物中的苯并荜芘异喹啉类季铵型生物碱，近年来的广泛研究发现其具有降血糖、降血脂、抗心律失常、抗血小板聚集、增强机体免疫功能等作用，本文就近年研究黄连素降糖、降脂、减肥、抗动脉粥样硬化等在代谢综合征中的防治作用作一综述。
Abstract:
Metabolic syndrome is a pathological condition of abnormal accumulation of diverse metabolic ingredients. Most abnormal metabolic ingredients have a close relation with hypertension, diabetes, hyperlipidemia and hyperinsulinemia. Berberine is an isoquinoline alkaloid isolated from Chinese medicinal herbs such as Coptidis rhizome. In recent years it was reported to have beneficial effects on the metabolic disorders of diabetes.

参考文献/References

[1]Hu Y,Davies GE.Berberine inhibits adipogenesis in high-fat diet-induced obesity mice[J].Fitoterapia,2010,81(5):358-366.
[2]东野圣伊,张惠杰,张志国,等.盐酸小檗碱对糖尿病小鼠胰岛细胞增殖与凋亡的影响[J].内科理论与实践,2012,7(3):169-174.
[3]陈远航,邓诗清,黄小玲.黄连素的降血糖药效学试验与临床观察[J].中国实用医药,2006,1(1):23-25.
[4]何明坤,陆付耳,王开富,等.小檗碱对高脂血症伴胰岛素抵抗大鼠糖脂代谢的影响[J].中国医院药学杂志,2004,24(7):389-391.
[5]丁来标，陆付耳，叶爱丽，等.黄连解毒汤对胰岛素抵抗大鼠瘦素和抵抗素的影响[J].中国中西医结合杂志,2006,26(3):232-235.
[6]Leng SH,Lu FE,Xu LJ.Therapeutic effects of berberine in impaired glucose tolerance rats and its influence on insulin secretion[J].Acta Pharmacol Sin,2004,25(4):496-502.
[7]Hwang JM,Wang CJ,Chou FP,et al.Inhibitory effect of berberine on tert-butyl hydroperoxide-induced oxidative damage in rat liver[J].Arch Toxicol,2002,76(11):664-670.
[8]宋菊敏，李石良.黄连素对非胰岛素依赖性糖尿病大鼠的抗氧化作用[J].中草药,1992,23(7):90.
[9]吕俊华，张世平，潘竞铿.小檗碱对D-半乳糖诱导糖基化模型大鼠血糖、血脂和肝肾功能的影响[J].中国中医基础医学杂志,2007,13(1):47-49.
[10]吴林根，陈 敏，吴 旸.黄连素对高尿酸血症的影响[J].中国中西医结合杂志,2010,30(6):659-662.
[11]陈 颖，苗志敏，阎胜利，等.各种脂质对肾小管上皮细胞人尿酸盐转运子基因表达的影响[J].中华内分泌代谢杂志,2009,25(1):22-24.
[12]张 茜，肖新华，王 彤，等.黄连素降糖调脂机制的研究[J].中国实验动物学报,2011,19(1)2:9-33.
[13]Xie X,Li W Y,Lan T,et al.Berberine ameliorates hyperglycemia in alloxan-induced diabetic C57BL/6 mice through activationof Akt signaling pathway[J]. Endocrine J,2011,58(9):761-768.
[14]Liu L,Yu YL,Yang JS,et al.Berberine suppresses intestinal disaccharidases with beneficial metabolic effects in diabetic states, evidences from in vivo and in vitro study [J].NaunynSchmiedebergs Arch Pharmacol,2010,Apr; 381(4):371-381.
[15]Brusq JM,Ancellin N,Grondin P,et al.Inhibition of lipid synthesis through activation of AMP kinase: an additional mechanism for the hypolipidemiceffects of berberine[J].J Lipid Res,2006,47(6):1281-1288.
[16]Abidi P,Zhou Y,Jiang JD,et al.Extracellular signal-regulated kinase-dependent stabilization of hepatic low-density lipoprotein receptor mRNA by herbal medicine berberine[J].Arterioscler Thromb Vasc Biol,2005,25(10):2170-2176.
[17]Choi BH,Ahn IS,Kim YH,et al.Berberine reduces the expression of adipogenic enzymes and inflammatory molecules of 3T3-L1adipocyte[J].EXP Mol Med,2006,38(6):599-605.
[18]吴林根，陈 敏. 黄连素谷维素伍用对血脂和体重的影响[J].临床心血管病杂志,2007,23(8):38.
[19]Kong W,WeI J,Abidi P,et al.Berberine is a novel cholesterol-lowering drug working through aunique mechanism distinct from statins[J].Nat Med, 2004,10(12):1344-1351.
[20]王树海,王文健,汪雪峰,等.黄芪多糖和小檗碱对3T3-L1脂肪细胞糖代谢及细胞分化的影响[J].中国中西医结合杂志,2004,24(10):926-928.
[21]王 宁，张 娟，建方方,等.小檗碱激活AMPK 抑制3T3-L1脂肪细胞分化[J].放射免疫学杂志,2012,25(3):273-275.
[22]Lee YS,Kim WS,Kim KH,et al.Berberine, a natural plant product activates-AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin -resistant states[J].Diabetes,2006,55(8):2256-2265.
[23]刘礼乐，张少君，罗婵清，等.盐酸小檗碱治疗非酒精性脂肪肝34例[J].实用医学杂志,2006,22(21):2519-2520.
[24]张焕鑫，张宏考，王家宁，等.小檗碱对兔颈动脉血管成形术后再狭窄的影响[J].郧阳医学院学报,2006,25(1):10-12.
[25]袁良俊，张宏考，张焕鑫，等.黄连素与辛伐他汀对大白兔血管成形术后再狭窄作用的比较[J].中国临床药理学杂志,2007,23(1):9.
[26]左彦方，郭 毅，姜 昕，等.小檗碱对兔动脉粥样硬化及其血脂的影响[J].中国脑血管病杂志,2006, 3(5):204-204.
[27]何厚国，刘 勇，艾志兵，等.小檗碱对兔颈动脉粥样硬化形成的干预作用[J].神经损伤与功能重建, 2006, 1(1):42-44.
[28]洪缨，解欣然，谢俊大，等. 小檗碱对压力负荷致心肌肥厚模型大鼠心脏结构的影响[J].北京中医药大学学报,2006,29(7):465-467.
[29]Steffel J,Luscher TF,Tanner FC.Tissue factor in cardiovascular diseases: molecular mechanisms and clinical implications[J].Circulation,2006,113(5):722-731.
[30]陈 玲，寇俊萍，余伯阳.Inhibition of berberine on tissue factor activity and venous thrombosis[J].中草药,2011,42(7):1389-1392..
[31]Stein TD,Anders NJ,DeCarli C.Neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (APP) in APPSW mice resulting in tau phosphorylation and loss of hippocampal neurons: support for the amyloid hypothesis[J].J Neurosci,2004,24(35):7707-7717.
[32]Mruthinti S,Capito N,Sood A,et al.Cytotoxicity of Abetal-42,RAGE23-54,and an Abeta-RAGE complex in PC-12 cells[J].Curr Alzheimer Res,2007,4(5): 581-586.
[33]王 静.张艳军.常亮堂.小檗碱对Aβ25-35损伤大鼠皮层神经元的保护作用[J].中草药,2011,42(4):728-733.
[34]张艳波,王 军.王 勇.等.小檗碱对大鼠脑缺血再灌注损伤脑组织Bcl-2 和Caspase-2表达的影响[J].中国老年医学杂志,2011,31(13):2482-2484.
[35]潘龙瑞,凌金祖,彭吉霞,等.小檗碱对糖尿病大鼠外周神经功能及神经病理性痛的影响[J].中国老年学杂志,2011,31(4):628－630

备注/Memo

备注/Memo:
收稿日期：2014-06-10.
通讯作者：吴林根，主任医师，主要从事代谢综合征与糖尿病研究Email：wlg0930@sohu.com
共同通讯作者：王燕，主管药师，主要从事肿瘤内科临床药学研究Email：wangyansjtu@163.com
更新日期/Last Update: 2015-02-03