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|本期目录/Table of Contents|

三种造影剂在cTTE检出PFO-RLS效果的比较

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2015年第4期
页码:
404-406
栏目:
结构性心脏病
出版日期:
2015-04-20

文章信息/Info

Title:
Comparison of three different acoustic contrast agents for detecting right to left shunt in patients with patent foramen ovale by contrast transthoracic echocardiography
作者:
李 阳1; 2; 王英莉2; 张玉顺3; 廉秋芳2
(1.西安交通大学医学院，陕西 西安 710061；
2.延安大学咸阳医院心血管内科，陕西 咸阳 712000，3.西安交通大学第一附属医院心内二科，陕西 西安 710061)
Author(s):
LI Yang1; 2;  WANG Ying-li2;  ZHANG Yu-shun3;  LIAN Qiu-fang2
(1.Health Science Center, Xi’an Jiaotong University, Xi’an 710061, Shaanxi, China；
2.Department of Cardiology, Xianyang Hospital of Yan’an University, Xianyang 712000, Shaanxi, China；
3.Second Department of Cardiology, First Affiliated Hospital, Xi’an Jiaotong University, Xi’an 710061, Shaanxi, China)
关键词:
经胸超声心动图声学造影; 声学造影剂; 卵圆孔未闭
Keywords:
right heart contrast echocardiography;  contrast agent;  patent foramen ovale
分类号:
R541.1
DOI:
-
文献标识码:
A
摘要:
目的 比较3种声学造影剂对经胸超声心动图声学造影（cTTE）检查卵圆孔未闭（PFO）右向左分流（RLS）的检出效果。方法 随机选取偏头痛及不明原因脑梗死患者84例。所有患者先后用激活生理盐水（AS）、加血激活生理盐水（ASB）和碳酸氢钠维生素B6溶液（VSBS）行cTTE检查，观察有无PFO-RLS及分级。结果 3种造影剂cTTE检查PFO-RLS阳性检出率（阳性率）分别为：AS组25%，ASB组27%和VSBS组36%。VSBS组显著高于AS组和ASB组（均P<0.05）。AS组与ASB组无显著差异。对比AS组PFO-RLS阳性患者3种造影剂检出PFO-RLS的半定量分级显示，ASB组中量和大量RLS阳性率均高于AS组(P<0.05)，而VSBS组大量RLS阳性率显著高于AS组和ASB组（均P<0.05）。结论 用VSBS行cTTE检查，对PFO-RLS检测的敏感性及显影效果均优于AS和ASB。
Abstract:
AIM To explore the detection sensitivity and developing effect of three kinds of acoustic contrast agents in right heart contrast echocardiography for diagnosis of patent foramen ovale (PFO). METHODS Eighty-four patients with migraine and cryptogenic stroke (aged 18 to 65 years) were enrolled and the right heart contrast echocardiography was conducted using three contrast agents. Real-time observation and comparison of the appearance of microbubble and microbubble density determined whether PFO with right to left shunt (RLS), and the detection rate and the developing effect of PFO using three contrast agents were compared. RESULTS All 84 patients underwent right heart contrast echocardiography examinations three times using three contrast agents. The positive rate of detection was 25% in the agitated saline solution (AS) group, 27% in the agitated saline solution with blood (ASB) group, and 36% in the Vitamin B6 and sodium bicarbonate solution (VSBS) group, which was higher than those of the former two groups. For developing effects, the VSBS group ranked top, followed by the ASB group, and the two groups were better than the AS group. CONCLUSION For detection sensitivity and developing effect, Vitamin B6 and sodium bicarbonate solution is superior to agitated saline solution and agitated saline solution with blood in right heart contrast echocardiography for diagnosis of patent foramen ovale, which is worthy of clinical popularization and application.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2015-03-17.
通讯作者：张玉顺，教授，主要研究先心病的诊断和介入治疗 Email：zys2899@sina.com
作者简介：李阳，硕士生 Email：liy2111@163.com
更新日期/Last Update: 2015-04-22