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|本期目录/Table of Contents|

疏血通注射液对STEMI患者直接PCI术心肌灌注和临床预后的影响

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2015年第4期
页码:
431-433,447
栏目:
临床研究
出版日期:
2015-04-20

文章信息/Info

Title:
Effect of shuxuetong injection on patients with acute ST-elevation myocardial infarction undergoing primary PCI
作者:
周晗颖; 张文全; 金惠根; 刘宗军; 杨 伟; 汪蔚青; 汪志华
(上海中医药大学附属普陀医院、上海市普陀区中心医院，上海 200062)
Author(s):
ZHOU Han-ying;  ZHANG Wen-quan;  JIN Hui-gen;  LIU Zong-jun;  YANG Wei;  WANG Wei-qing;  WANG Zhi-hua
(Department of Cardiology, Putuo District Central Hospital, Shanghai 200062, China)
关键词:
心肌梗死; 急性;  疏血通;  替罗非班; 经皮冠脉介入治疗
Keywords:
myocardial infarction;  shuxuetong;  tirofiban;  percutaneous coronary intervention
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 探讨应用疏血通注射液对ST段抬高型急性心肌梗死（STEMI）患者直接经皮冠状动脉介入治疗（PCI）术后心肌灌注和临床预后的影响。方法 80例行直接PCI的STEMI患者随机分为疏血通组（40例）和替罗非班组（40例），比较两组基础临床情况、介入治疗结果、术后30 min ST段回落情况、出血事件、住院期间左室射血分数(LVEF)及6个月内主要心脏不良事件(MACE)（死亡、再次心肌梗死、靶血管的再次血运重建、严重心力衰竭）。结果 共有79例完成试验，两组术前血管开通率、术后TIMI血流、校正的TIMI血流帧数（CTFC）、术后30 min ST段回落>50%的获得率、出血事件、住院和随访期间MACE的发生率均无明显差异。疏血通组和替罗非班组在住院期间各有1例死亡，在6个月随访期间疏血通组有1例死亡，1例复发心肌梗死，替罗非班组有1例行冠状动脉旁路移植术。结论 疏血通注射液联合STEMI直接PCI术在改善PCI术后的心肌灌注和患者的临床预后方面与替罗非班无显著差异。
Abstract:
AIM To investigate the effect of shuxuetong injection on patients with acute ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). METHODS Eighty STEMI patients who were to receive primary PCI were randomly assigned to shuxuetong injection group (n=40) and tirofiban group (n=40). Baseline characteristics of the two groups were compared. At the end of the PCI procedure, angiographic features including TIMI flow grade, corrected TIMI frames count and resolution of the sum of ST-segment elevation 30 min after primary PCI were analyzed immediately. The occurrence rate of MACE (death, reinfarction, heart failure, and revascularization) at 6 months after procedure was also compared between groups. RESULTS A total of 79 STEMI patients comprised the study. There was no significant difference between groups in initial angiography before PCI and there was no significant difference between groups in TIMI flow grade, corrected TIMI frames count and resolution of the sum of ST-segment elevation 30 min after primary PCI. No significant difference was found in MACE rate between groups at 6 months after the procedure. CONCLUSION In patients with STEMI undergoing primary PCI, shuxuetong injection improves coronary flow and myocardial perfusion.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2014-08-02.
基金项目：上海市医学重点专科项目资助（ZK2012B05）
通讯作者：金惠根，教授，主要从事冠心病和心律失常的介入治疗研究 Email：jhg1953@126.com
作者简介：周晗颖，硕士生 Email：zhou_hanying@163.com
更新日期/Last Update: 2015-04-22