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|本期目录/Table of Contents|

缺血/再灌注后心肌细胞死亡方式的选择及其机制探讨

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2015年第4期
页码:
470-473
栏目:
综述
出版日期:
2015-04-20

文章信息/Info

Title:
Indicators and mechanism of myocardial cell death after ischemia/reperfusion
作者:
郭伟楠1; 殷 玥2综述; 马 恒2审校
(第四军医大学：1.学员一旅，2.生理学教研室，陕西 西安 710032)
Author(s):
GUO Wei-nan1;  YIN Yue2;  MA Heng2
(1.First Cadet Brigade, 2.Department of Physiology, Fourth Military Medical University, Xi’an 710032, Shaanxi, China)
关键词:
心肌缺血/再灌注; 细胞程序性坏死; 细胞凋亡
Keywords:
myocardial ischemia/reperfusion;  necroptosis;  apoptosis
分类号:
R54
DOI:
-
文献标识码:
A
摘要:
心肌缺血/再灌注(MI/R)损伤是临床治疗中亟待解决的问题。心肌细胞为终末细胞，MI/R损伤导致的心肌细胞死亡会不可逆地损伤心脏的结构和功能，导致心肌纤维化、心衰等后果。坏死和凋亡是心肌细胞死亡的两种主要方式。以往认为，坏死是非程序性的细胞死亡。近期研究发现，心肌细胞的坏死并非不可控，坏死也受细胞内信号机制调控，称为程序性坏死（necroptosis）。MI/R后，通过心肌细胞膜上的死亡受体介导，心肌细胞可以经一系列可调节的分子信号通路，在凋亡和程序性坏死中做出选择。本文就MI/R后心肌细胞死亡方式的选择及其调控机制作一综述。
Abstract:
Myocardial ischemia/reperfusion (MI/R) injury is a problem urgently needed to be solved in clinical treatment. Myocardial cells are end cells. The death of myocardial cells caused by MI/R injury can lead to irreversible damage of the heart structure and functions and result in myocardial fibrosis and heart failure. Necrosis and apoptosis are the two main indicators of myocardial cell death. Necrosis was regarded as non-programmed cell death. However, recent studies revealed that myocyte necrosis is not uncontrollable and can be regulated by signaling pathways, referred to as necroptosis. After MI/R, myocardial cells, with the mediation of the death receptors on myocardial cell membranes, may make a choice between apoptosis and necroptosis through a series of regulated molecular signaling pathways. In this review,indicators of myocardial cell death after ischemia/reperfusion and its mechanisms are discussed.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2014-09-17.
基金项目：国家自然科学基金资助项目（81322004，81170108，31201037）
通讯作者：马恒，副教授，主要从事心肌内源性保护机制研究 Email：hengma@fmmu.edu.cn
作者简介：郭伟楠，本科生 Email：745149236@qq.com
更新日期/Last Update: 2015-04-22