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|本期目录/Table of Contents|

缺血性心力衰竭患者心房颤动与血清尿酸水平的关联性

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2015年第5期
页码:
582-584
栏目:
临床研究
出版日期:
2015-05-05

文章信息/Info

Title:
Effect of serum uric acid levels on atrial fibrillation in patients with ischemic heart failure
作者:
冯天福; 赵华云; 罗智敏; 罗子幸
(佛山市中医院内六科，广东 佛山 528000）
Author(s):
FENG Tian-fu;  ZHAO Hua-yun;  LUO Zhi-min;  LUO Zi-xing
(Department of Cardiology, Foshan Traditional Chinese Medical Hospital, Foshan 528000, Guangdong, China)
关键词:
心力衰竭; 缺血性; 心房颤动; 血清尿酸
Keywords:
ischemic heart failure;  atrial fibrillation;  serum uric acid
分类号:
R541
DOI:
-
文献标识码:
A
摘要:
目的 探讨缺血性心力衰竭（HF）患者心房颤动（AF）与血清尿酸（SUA）水平的关联性。方法 连续性收集于2012年10月~2014年10月就诊于佛山市中医院的缺血性HF患者363例，根据心电图或者病史记录将患者分为AF组和无AF组，比较两组间基线特征及SUA与AF的相关性。结果 363例患者中，共有78例患者患有AF，285例患者为正常窦性心律。与无AF患者相比，AF患者的SUA水平显著提高〔(64±21) vs.(57±19) mg/L，P<0.01〕。同时，AF组患者的年龄更大〔(71±8) vs.(66±11)岁，P<0.01〕。此外，AF患者的超声心动图指标，包括左室射血分数、左房内径、左心室舒张末期内径以及左心室舒张末期容积，同样显著高于窦性心律正常的患者。多因素回归分析显示，校正相关影响因素后，SUA水平仍为AF的独立相关因素(OR=1.27，95% CI，1.06-1.52，P≤0.01)。结论 SUA水平是缺血性HF患者AF的独立相关因素。
Abstract:
AIM To investigate the effect of serum uric acid (SUA) levels on atrial fibrillation (AF) in patients with ischemic heart failure (HF). METHODS A total of 363 consecutive patients with ischemic HF enrolled in our hospital were divided into two groups: AF group and non-AF group. We examined the baseline characteristics between groups and evaluated the relationship between SUA and AF by multivariate logistic regression analysis. RESULTS AF occurred in 21.5% (78/363) patients and 78.5% (285/363) patients had normal sinus rhythm. SUA levels in AF patients were significantly increased compared with those in normal sinus rhythm patients ［(6.4±2.09) vs.(5.7±1.9) mg/dl, P<0.001］. Age in AF patients was significantly higher than in normal sinus rhythm patients ［(71±8) vs.(66±11) mg/dl, P<0.01］. Echocardiographic parameters including ejection fraction, left atrial diameter, left ventricle end-diastolic diameter and left ventricle end-diastolic volume in AF patients were also significantly higher than those in normal sinus rhythm patients. Multivariate analysis showed that SUA was an independent risk factor of AF in patients with ischemic HF (OR=1.27, 95% CI, 1.06-1.52, P=0.010). CONCLUSION SUA level is significantly higher in AF patients and is independently associated with AF in patients with ischemic HF.

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备注/Memo

备注/Memo:
收稿日期：2014-11-18.
作者简介：冯天福，住院医师，硕士 Email:ftf201411@126.com
更新日期/Last Update: 2015-04-28