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《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:

2015年第5期

页码:

617-620,628

栏目:

综述

出版日期:

2015-05-05

文章信息/Info

Title:

Vascular smooth muscle cell phenotypic switching in vascular calcification

作者:

林 芳; 刘 越; 傅 羽; 尹新华

(哈尔滨医科大学附属第一医院心内科，黑龙江 哈尔滨 150001)

Author(s):

LIN Fang;  LIU Yue;  FU Yu;  YIN Xin-hua

(Department of Cardiology, First Affiliated Hospital, Harbin Medical University, Harbin 150001, Heilongjiang, China)

关键词:

血管平滑肌; 表型转化; 标志物; 血管钙化

Keywords:

vascular smooth muscle cell;  phenotypic switching;  markers;  vascular calcification

分类号:

R543

DOI:

-

文献标识码:

A

摘要:

血管钙化是一种由细胞所介导、主动的生物矿化过程，可增加心血管疾病的患病率和死亡率，并严重危害人类的健康和生活。越来越多的研究证实血管平滑肌细胞(Vascular smooth muscle cell,VSMC)及表型转化（phenotypic switching）在血管钙化的发生发展中具有重要作用。本文将阐述VSMC的表型转化，向骨/软骨化表型转化不同时期的标志蛋白分子，并探讨其表型转化的调控因素，进而深入认识血管钙化的发病过程。

Abstract:

Vascular calcification (VC), an active, cell-mediated process of biomineralization, often poses a threat to human health and leads to cardiovascular morbidity and mortality. An increasing body of evidence confirms that vascular smooth muscle cells (VSMCs) and their phenotypic transformation play significant roles in VC. To add to our knowledge of VC, this review will focus on markers of osteochondrocyte-like VSMCs and explore factors regulating the transdifferentiation of VSMCs.

参考文献/References

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备注/Memo

备注/Memo:

收稿日期：2014-10-15.
基金项目：国家级大学生创新创业训练计划项目资助（201310226010）；哈尔滨市科技创新人才研究专项资金项目资助（2012RFXXS008）；国家自然科学基金项目资助(81200235、81200143)
通讯作者：尹新华,主任医师，主要从事心血管疾病基础研究 Email：liuyue198002 @163.com
作者简介：林芳，博士生 Email：linfang2008lf @126.com

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更新日期/Last Update: 2015-04-28