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|本期目录/Table of Contents|

MicroRNAs在血管钙化中的作用

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2015年第6期
页码:
729-731,739
栏目:
综述
出版日期:
2015-07-15

文章信息/Info

Title:
Role of microRNAs in vascular calcification
作者:
刘丽媛; 贺 媛; 王海昌
（第四军医大学西京医院心脏内科，陕西 西安 710032）
Author(s):
LIU Li-yuan;  HE Yuan;  WANG Hai-chang
(Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, Shaanxi, China)
关键词:
microRNAs; 破骨细胞; 血管平滑肌细胞; 血管钙化
Keywords:
microRNAs;  osteoclast;  smooth muscle cell;  vascular calcification
分类号:
R543
DOI:
-
文献标识码:
A
摘要:
血管的钙化在冠心病患者是非常常见的，许多研究证实microRNAs(miRs)是血管钙化过程中一类重要的调节因子。人们对miRs的研究已取得一定进展，发现它可以通过调控平滑肌细胞的转分化、调节钙磷稳态、下调平滑肌细胞收缩表型等来引起血管钙化的发生。本文对miRs在血管钙化中所起的作用做一综述。
Abstract:
Vascular calcification is commonly found in coronary heart disease. Many studies reinforced that miRNA is an important regulatory factor in the development of vascular calcification. Study progress showed that miRNA could induce vascular calcification by regulating smooth muscle cell (SMC) transdifferentiation, regulating calcium and phosphate homeostasis and downregulating the SMC contractile phenotype, etc. In this article we summarized the functions of miRNAs in the process of vascular calcification.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2015-02-27.
通讯作者：王海昌,主任医师,主要从事心律失常及冠心病研究Email：wanghc@fmmu.edu.cn
作者简介：刘丽媛，住院医师,硕士 Email:lylacool@126.com 共同第一作者：贺媛，住院医师，硕士 Email：heyuan820927@163.com
更新日期/Last Update: 2015-07-23