我们的网站为什么显示成这样？

可能因为您的浏览器不支持样式，您可以更新您的浏览器到最新版本，以获取对此功能的支持，访问下面的网站，获取关于浏览器的信息：

|本期目录/Table of Contents|

急性冠脉综合征患者冠状动脉狭窄程度与左室射血分数的相关性

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2016年第1期
页码:
50-052
栏目:
临床研究
出版日期:
2015-09-15

文章信息/Info

Title:
Relationship between left ventricular ejection fraction and angiographic characteristics of acute coronary syndrome
作者:
齐疏影; 曾玉杰; 韩福生; 马临安
（首都医科大学附属北京安贞医院抢救中心，北京 100029）
Author(s):
QI Shu-ying;  ZENG Yu-jie;  HAN Fu-sheng;  MA Lin-an
(Emergency Center, Beijing Anzhen Hospital, Capital University of Medical Sciences, Beijing 100029, China)
关键词:
急性冠脉综合征; 冠状动脉狭窄; 射血分数
Keywords:
acute coronary syndrome;  coronary stenosis;  left ventricular ejection fraction
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 探讨急性冠脉综合征（ACS）患者冠状动脉狭窄程度与左室射血分数（LVEF）的相关性。方法 分析 647例ACS患者，按ACS患者冠状动脉狭窄程度的Gensini评分分为2组:Gensini≥45组(328例）和Gensini<45组(319例）。比较组间基线特征差异。采用Gensini评分系统对每位患者造影结果进行评分，用以衡量冠状动脉狭窄程度。应用Spearman双侧相关分析及多因素回归分析研究Gensini评分与LVEF的关系。结果 Gensini评分较高组，其FBG、HbA1c、WBC、LA均升高，LVEF、HDL-C及Ca2+降低。Spearman相关分析显示Gensini评分与心脏LVEF呈显著负相关（r=-0.28，P<0.01）。多因素回归分析结果表明，冠状动脉狭窄程度的积分与心脏LVEF独立相关，其偏相关系数β=-0.313，P<0.01。结论 ACS患者冠状动脉狭窄程度与LVEF独立相关。
Abstract:
AIM To investigate the relationship between left ventricular ejection fraction (LVEF) and angiographic characteristics of acute coronary syndrome (ACS). METHODSA total of 647 patients with ACS were divided into two groups according to Gensini score. Three hundred and twenty-eight patients were in group A with Gensini ≥45%; 319 were in group B with Gensini <45%. Baseline characteristics were analyzed between groups. Severity of coronary atherosclerosis was defined by the Gensini score system. Statistical methods including one-way ANOVA, Kruskal-Wallis test, Spearman correlation analysis and multivariate stepwise linear regression analysis were employed to explore the relationship between EF and Gensini score. RESULTSIn group A, FBG, HbA1c, WBC and LA were increased. LVEF, HDL and calcium ion were decreased. Spearman correlation indicated that Gensini score significantly correlated with the LVEF (r=-0.28, P<0.01). The result from the multivariate stepwise linear regression analysis showed that LVEF (β=-0.313, P<0.01) was significantly and independently associated with the Gensini score. CONCLUSIONEF is significantly and positively associated with Gensini score in patients with ACS.

参考文献/References

[1]陈灏珠.实用内科学[M].第14版,北京:人民卫生出版社,2013:1467.
[2]Shah PK,Falk E,Badimon JJ,et al.Human monocyte-derived macrophages induce collagen breakdown in fibrous caps of atherosclerotic plaques[J].Circulation,1995,92(6):1565-1569.
[3]Bennett KM,Hernandez AF,Chen AY,et al.Heart failure with preserved left ventricular systolic function among patients with non-ST-segment elevation acute coronary syndromes[J].Am J Cardiol,2003,91(10):1168-1172.
[4]Fukuda S,Hozumi T,Watanable H,et al.Usefulness of contrast echocardiography to improve the feasibility and accuracy of automated measurements of left ventricular volume and ejection fraction in patients with coronary disease[J].Am J Cardiol,2003,92(1):71-74.
[5]Zabalgoitia M,Beming J,Koren MJ,et al.Impact of coronary artery disease on left ventricular systolic function and geometry in hypertensive patients with left ventricular hypertrophy(the LIFE study)[J].Am J Cardiol,2001,88(6):646-650.
[6]Dragoichev C,Savova A,Stoichev S,et al.Determinants of the left ventricular function in patients with coronary heart disease: a multivariate approach[J].Cor Vasa,1984,26(5):353-360
[7]马丽萍,秦永文,郑 兴,等.冠状动脉病变程度对左室功能的影响[J].中华老年心脑血管病杂志,2002,4(2):84-86.
[8]江时森,黄浙勇,蔡晓敏,等.冠状动脉病变程度对左室射血分数的影响[J].微循环学杂志,2005,15(1):45-48.
[9]Kalra DK,Zoghbi WA.Myocardial hibernation in coronary artery disease[J].Curr Atheroscler Rep,2002,4(2):149-155.
[10]Bukachi F,Clague JR.Clinical outcome of coronary angioplasty in patients with ischaemic cardiomyopathy[J].Am J Cardiol,2003,88(2-3):167-174.
[11]Schinkel AF,Poldemans D,Vanorerschelde JL,et al.Incidence of recovery of contractile function following revascularization in patients with ischemis left ventricular dysfunction[J].Am J Cardiol,2004,93(1):14-17.
[12]Wison S,Foo K,Cunningham J,et al.Renal function and risk stratification in acute coronary syndromes[J].Am J Cardiol,2003,91(9):1051-1054.
[13]陈汉明,刘文娴,张丽洁.2型糖尿病合并冠心病患者冠脉病变与糖化血红蛋白水平的关系[J].中国介入心脏病学杂志,2011,19(2):88-90.

备注/Memo

备注/Memo:
收稿日期：2014-11-30.
作者简介：齐疏影，住院医师，硕士 Email：qshy0310@sina.com
更新日期/Last Update: 2015-09-16