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|本期目录/Table of Contents|

青年早发冠心病的病变特点和危险因素

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2016年第1期
页码:
56-059
栏目:
临床研究
出版日期:
2015-09-15

文章信息/Info

Title:
Clinical characteristics and risk factors in young patients with early-onset coronary heart disease
作者:
李 强1; 2; 刘昱圻1; 高 明1; 马 强1; 薛萧迪1; 荆 晶1; 陈韵岱1
(解放军总医院:1.心内科，2.健康管理研究院国宾检验中心,北京 100853)
Author(s):
LI Qiang1; 2;  LIU Yu-qi1;  GAO Ming1;  MA Qiang1;  XUE Xiao-di1;  JING Jing1;  CHEN Yun-dai1
(1.Department of Cardiology, 2.Laboratory Center of Health Management Institute, PLA General Hospital, Beijing 100853, China)
关键词:
青年; 冠状动脉疾病; 危险因素
Keywords:
young patients;  coronary heart disease;  risk factors
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 分析青年早发冠心病患者的临床特点以及危险因素。 方法 按照入选、排除标准，分为青年早发冠心病组（199例年龄≤40岁冠心病患者）、老年冠心病组（1737例年龄≥65岁冠心病患者） 和健康对照组（204例年龄≤40岁冠脉造影正常的对照者），对3组患者的相关资料进行回顾性统计分析，比较3组的年龄、体质量指数、血压、心率、吸烟、家族史等基础情况，以及并发的高血压病、糖尿病、高脂血症、脑血管疾病、肾功能不全等，分析两组的差异性。 结果 青年冠心病以前降支病变为主，主要为单支病变，且发病较急是其冠脉病变特点。青年早发冠心病组中男性、吸烟史，冠心病家族史并发高血压、糖尿病高于健康对照组，而老年冠心病患者并发高血压、糖尿病、高脂血症、脑血管疾病发病率更高，有统计学差异（P<0.05），多因素logistic回归分析结果显示吸烟、家族史、糖尿病、高脂血症是青年冠心病独立危险因素，饮酒有一定保护作用。结论 吸烟、冠心病阳性家族史，糖尿病、高脂血症是青年早发冠心病主要的危险因素。
Abstract:
AIM To analyze the clinical characteristics and risk factors in young patients with early-onset coronary heart disease (CHD). METHODSAccording to the inclusion and exclusion criteria, enrolled in this study were 199 patients 40 years of age and diagnosed with coronary artery disease, 1 737 patients≥65 years with CHD and 204 individuals <40 years as normal controls. Retrospective clinical data were analyzed and compared among the three groups including age, body mass index, blood pressure, heart rate, smoking, family history, hypertension, diabetes, hyperlipidemia, cerebral vascular disease and renal insufficiency. RESULTSCoronary angiography showed that young patients mainly presented with anterior descending coronary artery lesion, single-vessel disease and acute occlusion. The ratio of male patients, smoking history, family history, hypertension and diabetes mellitus in young CHD group was higher than in the control group, and the ratio of hypertension, diabetes and hyperlipidemia in elderly patients was higher. Multiple logistic correlation analysis showed that smoking, family history, diabetes and hyperlipidemia were independent risk factors in young CHD patients, whereas alcohol consumption had some preventive effect on CHD. CONCLUSIONSmoking, positive family history of CHD, diabetes and hyperlipidemia are major risk factors in young patients with early-onset CHD.

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备注/Memo

备注/Memo:
收稿日期：2014-12-22.
通讯作者：陈韵岱，主任医师，主要从事冠心病,复杂冠脉介入治疗研究 Email:cyundai@126.com
作者简介：李强，技士，硕士生(在职) Email:ametuofo4290@gmail.com
更新日期/Last Update: 2015-09-16