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|本期目录/Table of Contents|

电刺激犬心室神经节丛对自主神经介导房颤的影响

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2016年第2期
页码:
149-152
栏目:
基础研究
出版日期:
2015-11-25

文章信息/Info

Title:
Effect of electrical stimulation of aortic root ventricular ganglionated plexi on autonomic nervous system-mediated atrial fibrillation
作者:
范博渊1何宜轩2王 彬1艾永飞1马文帅1赵楠楠1王洪涛1
(第四军医大学:1.唐都医院心脏内科,陕西 西安 710038,2.学员旅二营五连,陕西 西安 710032)
Author(s):
FAN Bo-yuan1 HE Yi-xuan2 WANG Bin1 AI Yong-fen1 MA Wen-shuai1 ZHAO Nan-nan1 WANG Hong-tao1
(1.Department of Cardiology, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, Shaanxi, China, 2.Cadet Brigade, Fourth Military Medical University, Xi’an 710032, Shaanxi, China)
关键词:
心室主动脉根部神经节丛自主神经系统肺静脉房颤
Keywords:
aortic root ventricular ganglionated plexi autonomic nervous system pulmonary vein atrial fibrillation
分类号:
R541.75
DOI:
-
文献标识码:
A
摘要:
目的 本研究探讨低频电刺激心室主动脉根部神经节丛(ganglionated plexi,GP)对肺静脉源性房颤(AF)诱发率的影响。方法 20只犬分别测量基础状态下,高频和低频电刺激主动脉根部GP时的心房有效不应期和肺静脉有效不应期。分别在基础状态下,高频和低频电刺激主动脉根部GP时,自肺静脉远端以程序刺激诱发AF和AF诱发率的变化。结果 高频电刺激主动脉根部GP 明显缩短心房的肺静脉的有效不应期,增加AF的诱发率。而低频电刺激使心房及肺静脉有效不应期呈延长趋势,并降低AF诱发率。结论 低频电刺激主动脉根部GP降低自主神经介导的AF诱发率。
Abstract:
AIM To investigate the effect of electrical stimulation of aortic root ventricular ganglionated plexi (GP) on autonomic nervous system-mediated atrial fibrillation (AF) inducibility. METHODS Effective refractory periods (ERP) of the atria and the pulmonary vein (PV) were measured at baseline, high-level (HL-ES) and low-level (LL-ES) electrical stimulation of aortic root ventricular GP. AF was induced at distal PV by programmed stimulation to measure AF inducibility at baseline, HL-ES or LL-ES. RESULTS HL-ES of aortic root GP significantly shortened ERP of the atria and ERP of the PVs and increased the AF-inducing rate arising from PVs. However, LL-ES of this GP prevented the shortening of ERP and decreased AF inducing rate. CONCLUSION LL-ES of aortic root ventricular GP decreases AF inducibility arising from PVs mediated by the autonomic nervous system.

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备注/Memo

备注/Memo:
收稿日期:2015-01-19.
基金项目:陕西省自然科学基金项目资助(2015JM8461)
通讯作者:王洪涛,主治医师,主要从事心律失常和心房颤动研究 Email:287561457@qq.com
作者简介:范博渊,住院医师,硕士 Email:277399335@qq.com
共同第一作者:何宜轩,本科生 Email:12558828376@qq.com
更新日期/Last Update: 2016-04-25