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|本期目录/Table of Contents|

自噬在心血管疾病中的作用

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2016年第2期
页码:
216-220,230
栏目:
综述
出版日期:
2015-11-25

文章信息/Info

Title:
Effect of autophagy in cardiovascular diseases
作者:
李程飞; 孙喜庆
（第四军医大学航空航天医学系航空航天生物动力学教研室、航空航天医学教育部重点实验室，陕西 西安 710032）
Author(s):
LI Cheng-fei;  SUN Xi-qing
(Department of Aerospace Biodynamics & MOE Key Laboratory of Aerospace Medicine, School of Aerospace Medicine, Fourth Military Medical University, Xi’an 710032, Shaanxi, China)
关键词:
自噬; 心血管疾病; 动脉粥样硬化; 高血压; 心力衰竭
Keywords:
autophagy;  cardiovascular diseases;  atherosclerosis;  hypertension;  heart failure
分类号:
R364
DOI:
-
文献标识码:
A
摘要:
自噬是一种维持细胞稳态的重要通路。在特定环境下，细胞中的多余蛋白质和受损细胞器通过自噬这一途径被降解。自噬在多种心血管疾病中的作用正逐渐被阐明，例如缺血/再灌注损伤、动脉粥样硬化、心律失常、高血压和心力衰竭等。本文介绍了影响自噬基本过程的主要分子和调控自噬活性的机制，讨论了自噬与多种心血管疾病之间的关系。
Abstract:
Autophagy is an important cellular pathway by which different cytosolic proteins and organelles are degraded under particular conditions, which is an essential mechanism that tissues utilize to maintain cellular homeostasis. The function of autophagy has been implicated in a wide range of cardiovascular diseases such as the ischemia/reperfusion injury, atherosclerosis, cardiac arrhythmias, hypertension and heart failure. In this review, we discuss the underlying mechanism manipulating the process of autophagy and introduce the links between autophagy and some cardiovascular diseases.

参考文献/References

[1]Kaushik S,Cuervo AM.Chaperone-mediated autophagy:a unique way to enter the lysosome world[J].Trends Cell Biol,2012,22(8):407-417.
[2]Mizushima N,Levine B,Cuervo AM,et al.Autophagy fights disease through cellular self-digestion[J].Nature,2008,451(7182):1069-1075.
[3]Lum JJ,DeBerardinis RJ,Thompson CB.Autophagy in metazoans:cell survival in the land of plenty[J].Nat Rev Mol Cell Biol,2005,6(6):439-448.
[4]Mathew R,Kongara S,Beaudoin B,et al.Autophagy suppresses tumor progression by limiting chromosomal instability[J].Genes Dev, 2007,21(11):1367-1381.
[5]Karantza-Wadsworth V,Patel S,Kravchuk O,et al.Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis[J].Genes Dev,2007,21(13):1621-1635.
[6]Kroemer G,Levine B.Autophagic cell death: the story of a misnomer[J].Nat Rev Mol Cell Biol,2008,9(12):1004-1010.
[7]Degenhardt K,Mathew R,Beaudoin B,et al.Autophagy promotes tumor cell survival and restricts necrosis,inflammation,and tumorigenesis[J].Cancer Cell,2006,10(1):51-64.
[8]Sun XT,Momen A,Wu J,et al.p27 protects metabolically-stressed cardiomyocytes from apoptosis by promoting autophagy[J].J Biol Chem,2014,289(24):16924-16935.
[9]Ryan KM.p53 and autophagy in cancer:Guardian of the genome meets guardian of the proteome[J].Eur J Cancer,2011,47(1):44-50.
[10]Kuma A,Mizushima N.Physiological role of autophagy as an intracellular recycling system:with an emphasis on nutrient metabolism[J].Semin Cell Dev Biol,2010,21(7):683-690.
[11]Russell RC,Tian Y,Yuan H,et al.ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase[J].Nat Cell Biol,2013,15(7):741-750.
[12]Settembre C,Fraldi A,Medina DL,et al.Signals from the lysosome:a control centre for cellular clearance and energy metabolism[J].Nat Rev Mol Cell Biol,2013,14(5):283-296.
[13]Settembre C,Ballabio A.TFEB regulates autophagy: an integrated coordination of cellular degradation and recycling processes[J].Autophagy,2011,7(11):1379-1381.
[14]Yu L,McPhee CK,Zheng L,et al.Termination of autophagy and reformation of lysosomes regulated by mTOR[J].Nature,2010,465(7300):942-946.
[15]Chen Y,Yu L.Autophagic lysosome reformation[J].Exp Cell Res,2013,319(2):142-146.
[16]Rong Y,McPhee CK,Deng S,et al.Spinster is required for autophagic lysosome reformation and mTOR reactivation following starvation[J].Proc Natl Acad Sci U S A,2011,108(19):7826-7831.
[17]Rong Y,Liu M,Ma L, et al.Clathrin and phosphatidylinositol-4,5- bisphosphate regulate autophagic lysosome reformation[J].Nat Cell Biol,2012,14(9):924-934.
[18]Luzio JP,Pryor PR,Bright NA,et al.Lysosomes: fusion and function[J].Nat Rev Mol Cell Biol,2007,8(8): 622-632.
[19]Huotari J,Helenius A.Endosome maturation[J].EMBO J,2011,30(17):3481-3500.
[20]Fader CM,Sanchez DG,Mestre MB,et al.TI-VAMP/VAMP7 and VAMP3/cellubrevin:two v-SNARE proteins involved in specific steps of the autophagy/multivesicular body pathways[J].Biochim Biophys Acta,2009,1793(12):1901-1916.
[21]Berg TO,Fengsrud M,Stromhaug PE,et al.Isolation and characterization of rat liver amphisomes.Evidence for fusion of autophagosomes with both early and late endosomes[J].J Biol Chem,1998,273(34):21883-21892.
[22]Shen HM,Mizushima N.At the end of the autophagic road:an emerging understanding of lysosomal functions in autophagy[J].Trends Biochem Sci,2014,39(2):61-71.
[23]Kim DH,Sarbassov DD,Ali SM,et al.mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery[J].Cell,2002,110(2):163-175.
[24]Inoki K,Li Y,Zhu T,et al.TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling[J].Nat Cell Biol,2002,4(9):648-657.
[25]Wang L,Harris TE,Roth RA,et al.PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding[J].J Biol Chem,2007,282(27):20036-20044.
[26]Sancak Y,Peterson TR,Shaul YD,et al.The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1[J].Science,2008,320(5882):1496-1501.
[27]Zhang L,Dai F,Cui L,et al.Novel role for TRPC4 in regulation of macroautophagy by a small molecule in vascular endothelial cells[J].Biochim Biophys Acta,2015,1853(2):377-387.
[28]Decuypere JP,Kindt D,Luyten T,et al.mTOR-controlled autophagy requires intracellular Ca(2+)signaling[J].PLoS One,2013,8(4):e61020.
[29]Zhang L,Jing H,Cui L,et al.3,4-Dimethoxystilbene, a resveratrol derivative with anti-angiogenic effect, induces both macroautophagy and apoptosis in endothelial cells[J].J Cell Biochem,2013,114(3):697-707.
[30]Hardie DG,Ross FA,Hawley SA.AMPK:a nutrient and energy sensor that maintains energy homeostasis[J].Nat Rev Mol Cell Biol,2012,13(4):251-262.
[31]Mammucari C,Milan G,Romanello V,et al.FoxO3 controls autophagy in skeletal muscle in vivo[J].Cell Metab,2007,6(6):458-471.
[32]Sengupta A,Molkentin JD,Yutzey KE.FoxO transcription factors promote autophagy in cardiomyocytes[J].J Biol Chem,2009,284(41):28319-28331.
[33]Hariharan N,Maejima Y,Nakae J,et al.Deacetylation of FoxO by Sirt1 plays an essential role in mediating starvation-induced autophagy in cardiac myocytes[J].Circ Res,2010,107(12):1470-1482.
[34]Canto C,Gerhart-Hines Z,Feige JN,et al.AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity[J].Nature,2009,458(7241):1056-1060.
[35]Egan DF,Shackelford DB,Mihaylova MM,et al.Phosphorylation of ULK1(hATG1)by AMP-activated protein kinase connects energy sensing to mitophagy[J].Science,2011,331(6016):456-461.
[36]Kim J,Kundu M,Viollet B,et al.AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1[J].Nat Cell Biol,2011,13(2):132-141.
[37]Inoki K,Zhu T,Guan KL.TSC2 mediates cellular energy response to control cell growth and survival[J].Cell, 2003,115(5):577-590.
[38]Kim J,Kim YC,Fang C,et al.Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy[J].Cell,2013,152(1-2):290-303.
[39]Sybers HD,Ingwall J,DeLuca M. Autophagy in cardiac myocytes[J].Recent Adv Stud Cardiac Struct Metab,1976,12:453-463.
[40]Matsui Y,Takagi H,Qu X,et al.Distinct roles of autophagy in the heart during ischemia and reperfusion: Roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy[J].Circ Res,2007,100(6):914-922.
[41]Hamacher-Brady A,Brady NR, Gottlieb RA. Enhancing macroautophagy protects against ischemia/reperfusion injury in cardiac myocytes[J].J Biol Chem,2006,281(40):29776-29787.
[42]Ouimet M,Franklin V,Mak E,et al.Autophagy regulates cholesterol efflux from macrophage foam cells via lysosomal acid lipase[J].Cell Metab,2011,13(6):655-667.
[43]Debnath J,Baehrecke EH,Kroemer G.Does autophagy contribute to cell death?[J].Autophagy,2005,1(2):66-74.
[44]Garcia L,Verdejo HE,Kuzmicic J,et al.Impaired cardiac autophagy in patients developing postoperative atrial fibrillation[J].J Thorac Cardiovasc Surg,2012,143(2):451-459.
[45]Chen MC,Chang JP,Wang YH,et al.Autophagy as a mechanism for myolysis of cardiomyocytes in mitral regurgitation[J].Eur J Clin Invest,2011,41(3): 299-307.
[46]Long L,Yang X,Southwood M,et al.Chloroquine prevents progression of experimental pulmonary hypertension via inhibition of autophagy and lysosomal bone morphogenetic protein type II receptor degradation[J].Circ Res,2013,112(8):1159-1170.
[47]Chao YM,Lai MD,Chan JY.Redox-sensitive endoplasmic reticulum stress and autophagy at rostral ventrolateral medulla contribute to hypertension in spontaneously hypertensive rats[J].Hypertension,2013,61(6):1270-1280.
[48]Shimomura H,Terasaki F,Hayashi T,et al.Autophagic degeneration as a possible mechanism of myocardial cell death in dilated cardiomyopathy[J].Jpn Circ J,2001,65(11):965-968.
[49]Kostin S,Pool L,Elsasser A,et al.Myocytes die by multiple mechanisms in failing human hearts[J].Circ Res,2003,92(7):715-724.
[50]Kassiotis C,Ballal K,Wellnitz K,et al.Markers of autophagy are downregulated in failing human heart after mechanical unloading[J].Circulation,2009,120(11 Suppl):S191-S197.
[51]Salabei JK,Balakumaran A,Frey JC,et al.Verapamil stereoisomers induce antiproliferative effects in vascular smooth muscle cells via autophagy[J].Toxicol Appl Pharmacol,2012,262(3):265-272.
[52]Andres AM,Hernandez G,Lee P,et al.Mitophagy is required for acute cardioprotection by simvastatin[J].Antioxid Redox Signal, 2014,21(14):1960-1973.
[53]He C,Zhu H,Li H,et al.Dissociation of Bcl-2-Beclin1 complex by activated AMPK enhances cardiac autophagy and protects against cardiomyocyte apoptosis in diabetes[J]. Diabetes,2013,62(4):1270-1281.

备注/Memo

备注/Memo:
收稿日期：2015-01-15.
基金项目：国家自然科学基金项目资助(81471817，81171872，81272175)
通讯作者：孙喜庆，教授，主要从事重力生理学研究 Email:sunxiqing@fmmu.edu.cn
作者简介：李程飞，硕士生 Email:Licf920305@163.com
更新日期/Last Update: 2016-04-25