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|本期目录/Table of Contents|

补体C1q肿瘤坏死因子相关蛋白3与急性冠脉综合征的关系

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2016年第3期
页码:
309-311
栏目:
临床研究
出版日期:
2016-01-05

文章信息/Info

Title:
The role of C1q/TNF-related protein-3 (CTRP-3) in patients with acute coronary syndrome
作者:
宋延彬1; 张君毅2; 李 华3; 张云清3; 陶 凌4
（延安大学附属医院：1.心内科，3.产科，陕西 延安 716000；
2.空军工程大学门诊部，陕西 西安 713800；
4.第四军医大学西京医院心内科，陕西 西安 710032）
Author(s):
SONG Yan-bin1;  ZHANG Jun-yi2;  LI Hua3;  ZHANG Yun-qing3;  TAO Ling4
(1.Department of Cardiology, 3.Obstetrics, Affiliated Hospital Yan’an University, Yan’an 716000 Shaanxi, China；
2.Outpatient Department, Air Force Engineering University Xi’an 713800 Shaanxi, China；
4.Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, Shaanxi, China)
关键词:
补体C1q肿瘤坏死因子相关蛋白3; 急性冠脉综合征; 脂肪因子
Keywords:
C1q tumor necrosis factor related proteins-3;  acute coronary syndrome;  adipokines
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 研究补体C1q肿瘤坏死因子相关蛋白3（C1q tumor necrosis factor related proteins-3,CTRP3）在急性冠脉综合征(acute coronary syndrome,ACS)患者中的表达及作用。方法 检测ACS患者206例和稳定型心绞痛（stable angina pectoris,SAP）患者208例血浆中CTRP3。结果 与SAP相比，ACS患者血浆CTRP3和脂联素（adiponectin,APN）显著降低（P<0.01）。校正年龄和性别后，CTRP3与血糖(r=-0.121,P<0.01)，高敏C反应蛋白(high sensitive C-reactive protein,hsCRP)(r=-0.152,P<0.01)负相关。与高密度脂蛋白胆固醇(r=0.112,P<0.01)和脂联素(r=0.136,P<0.01)正相关。多因素logistic回归分析发现：与高三分位数CTRP3组相比，中三分位数CTRP3组OR值5.08（95%可信区间，1.69-13.43），低三分位数OR值8.17（95%可信区间，2.36-28.36）。结论 CTRP3与ACS有关联。
Abstract:
AIM To analyze the relationship between C1q/TNF-related protein-3 (CTRP-3) and acute coronary syndrome (ACS). METHODSWe examined circulating CTRP-3 levels in 206 ACS patients and 208 patients with stable angina pectoris (SAP). RESULTSCompared with those in SAP patients, CTRP-3 levels significantly decreased in ACS patients. Correlation analysis adjusted for age and gender exhibited that CTRP-3 concentrations showed a significant negative relationship with glucose (r=-0.121, P<0.01) and hsCRP levels (r=-0.152, P<0.01) and a positive relationship with HDL-cholesterol (r=0.112, P<0.01) and adiponectin (APN) levels (r=0.136, P<0.01). Logistic analysis revealed that APN was negatively associated with ACS (r=-0.45, P<0.05) and after correcting some factors it was still negatively associated with ACS (r=-0.38, P<0.05). CTRP3 was not only negatively associated with ACS (r=-0.34, P<0.05) but also negatively associated with ACS after correcting some factors (r=-0.22, P<0.05). CONCLUSIONCTRP3 and APN are associated with ACS.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2015-06-29.
作者简介：宋延彬，副主任医师，博士 Email：592331246@qq.com
更新日期/Last Update: 2016-01-07