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Title:: Correlation between serum IL-6, visfatin and severity of coronary artery stenosis in patients with coronary heart disease

作者:: 张春艳; 王聪霞; 李永勤; 韩振华; 张岩; 宋雅璠; 贾珊; （西安交通大学第二附属医院心内科，陕西西安 710004)

Author(s):: ZHANG Chun-yan; WANG Cong-xia; LI Yong-qin; HAN Zhen-hua; ZHANG Yan; SONG Ya-fan; JIA Shan; (Department of Cardiology, Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, Shaanxi, China)

关键词:: 白介素-6; 内脂素; 冠状动脉疾病; 动脉粥样硬化

Keywords:: interleukin-6; visfatin; coronary heart disease; atherosclerosis

分类号:: R541.4

DOI:: -

文献标识码:: A

摘要:: 目的分析冠心病患者血浆白介素（IL）-6和内脂素水平与冠状动脉病变严重程度的相关性。方法选择经冠状动脉造影确诊的冠心病患者128例，分为急性冠脉综合征（ACS）组和稳定型心绞痛（SAP）组，并按病变血管支数分成3组（单支病变组、双支病变组和三支病变组），按冠状动脉狭窄程度分为3组（冠状动脉狭窄程度50%~75%组、76%~90%组及91%~100%组）。收集患者的基本临床资料，血浆IL-6及内脂素应用酶联免疫吸附法测定，应用Gensini积分评价冠状动脉病变严重程度。结果 ACS组患者IL-6及内脂素水平显著高于SAP组（P<0.05），按照不同病变血管支数分组和按照病变血管狭窄程度分组后，血浆IL-6及内脂素水平在各组间差异具有显著性（P<0.05）。相关分析显示IL-6、内脂素与Gensini积分呈正相关（分别r=0.583,r=0.724，均P<0.01）。结论 IL-6及内脂素与冠状动脉病变严重程度密切相关。

Abstract:: AIM To investigate the correlation between plasma IL-6, visfatin and severity of coronary stenosis in patients with coronary heart disease (CHD). METHODSA total of 128 patients with CHD confirmed by coronary angiography from our Department of Cardiology were divided into two groups: acute coronary syndrome (ACS) and stable angina pectoris (SAP). Patients were divided into three groups according to the number of blood vessel lesions: single lesion group, double branch lesion group and three branch lesion group and were divided into three groups on the basis of the degree of coronary artery stenosis: 50%-75% group, 76%-90% group and 91%-100% group. Clinical data of these patients were collected. ELISA kits were used to measure plasma levels of IL-6 and visfatin. Gensini score was used to evaluate the severity of coronary artery stenosis. RESULTSPlasma levels of IL-6 and visfatin in ACS group were significantly higher than those in SAP group (P<0.05). Plasma levels of IL-6 and visfatin were significantly different in patients grouped by the number of blood vessel lesions and degree of coronary artery stenosis (P<0.05). Correlation analysis showed that IL-6 and visfatin were positively associated with Gensini score (r=0.583 and 0.724, respectively, both P<0.01). CONCLUSIONPlasma IL-6 and visfatin are closely associated with the severity of coronary artery stenosis.

参考文献/References

[1]Bernberg E,Ulleryd MA,Johansson ME,et al.Social disruption stress increases IL-6 levels and accelerates atherosclerosis in ApoE-/- mice[J].Atherosclerosis,2012,221(2):359-365.
[2]Takeda N,Manabe I,Shindo T,et al.Synthetic retinoid Am80 reduces scavenger receptor expression and atherosclerosis in mice by inhibiting IL-6[J]. Arterioscler Thromb,2006,26(5):1177-1183.
[3]Petrovay F,Heltai K,Kis Z,et al.Chronic infections and histamine,CRP and IL-6 levels alter pereutaneous tl'a-18 luminal coronary angloplasty[J].Inflamm Res,2007,56(9):362-367.
[4]Gensini GG.A more meaningful scoring system for determining the severity of coronary heart disease[J].Am J Cardiol,1983,51(3):606.
[5]Dahl TB,Yndestad A,Skjelland M,et al.Increased expression of visfatin in macrophages of human unstable carotid and coronary atherosclerosis:possible role in inflammation and plaque destabilization[J].Circulation,2007,115(8):972-980.
[6]Nowell MA,Richards PJ,Fielding CA,et al.Regulation of pre-B cell colony-enhancing factor by STAT-3-dependent interleukin-6 tram-signaling:implications in the pathogenesis of rhemnatoid arthritis[J].Arthritis Rheum,2006,54(7):2084-2095.
[7]Liu SW,Qiao SB,Yuan JS,et al.Association of plasma visfatin levels with inflammation,atherosclerosis and acute coronary syndromes (ACS) in humans[J].Clin Endocrinol(Oxf),2009,71(2):202-207.
[8]王淑艳，唐与晓，孟晓梅，等.肥胖患者血清内脂素和白介素6的变化及相关因素分析[J].Chinese General Qractice,2011,14(18):2072-2073.

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冠心病患者血浆IL-6及内脂素水平与冠状动脉病变严重程度相关性研究

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

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