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|本期目录/Table of Contents|

microRNA Let-7在心血管疾病中的研究进展

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2016年第4期
页码:
476-478,487
栏目:
综述
出版日期:
2016-04-01

文章信息/Info

Title:
Research progress of microRNA let-7 in cardiovascular diseases
作者:
刘向兰; 吴 健; 朱静怡; 迟 迪; 孙 勇
(哈尔滨医科大学附属第二临床医学院心内科，教育部心肌缺血重点实验室，黑龙江 哈尔滨 150081)
Author(s):
LIU Xiang-lan;  WU Jian;  ZHU Jing-yi;  CHI Di;  SUN Yong
(Department of Cardiology, Second Affiliated Hospital of Harbin Medical & Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin 150081, Heilongjiang, China)
关键词:
microRNA let-7 ; 心脏发育; 心血管疾病; 循环标志物
Keywords:
microRNA let-7;  heart development;  cardiovascular diseases;  circulation biomarker
分类号:
R541
DOI:
-
文献标识码:
A
摘要:
microRNA let-7家族是在秀丽隐杆线虫中发现的长度21nt的microRNA之一。最近的研究发现它在心血管系统起到重要的调控作用。Let-7成员在心血管组织中特异性表达使其在心脏发育及心脏疾病的发生发展中发挥重要作用。目前， let-7的靶向基因主要是TLR4、LOX-1、Bcl-xl和AGO1，确定let-7靶基因和信号通路在心脏疾病的临床诊断和治疗上具有重要的应用前景。Let-7可能为一个潜在的治疗心血管疾病的目标。本文对 let-7在心血管疾病中的研究进展进行综述。
Abstract:
Let-7 family is one of the microRNAs that consists of 21 nucleotides found in C. elegans. Recent research has shown that it plays an important role in regulating the cardiovascular system. Let-7 members are important in the development of heart disease because let-7 is specifically expressed in cardiovascular tissue. So far, TLR4, LOX-1, Bcl-xl and AGO1 are the identified target genes of let-7. Let-7 may be a potential therapeutic target for cardiovascular diseases. This article reviews research progress of microRNA let-7 in cardiovascular diseases.

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备注/Memo

备注/Memo:
收稿日期：2015-03-18.
基金项目：国家自然基金青年基金项目资助（81200240），教育部重点实验室开放基金资助（KF201405）
通讯作者：孙勇，主任医师，主要从事先天性心脏病及冠脉血管介入治疗研究 Email：ssunyyong@126.com
作者简介：刘向兰，硕士生 Email：liuxianglan09061@126.com
更新日期/Last Update: 2016-04-01