我们的网站为什么显示成这样？

可能因为您的浏览器不支持样式，您可以更新您的浏览器到最新版本，以获取对此功能的支持，访问下面的网站，获取关于浏览器的信息：

|本期目录/Table of Contents|

健康青年脂肪分布对重要脏器血流的影响

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2016年第5期
页码:
573-578
栏目:
临床研究
出版日期:
2016-04-25

文章信息/Info

Title:
Influence of fat distribution on blood flow of major organs in young healthy subjects
作者:
马 婧; 袁丽君; 丰 杨; 张雅君; 邢长洋; 段云友; 曹铁生
（第四军医大学唐都医院超声诊断科，陕西 西安 710038）
Author(s):
MA Jing;  YUAN Li-jun;  FENG Yang;  ZHANG Ya-jun;  XING Chang-yang;  DUAN Yun-you;  CAO Tie-sheng
(Department of Ultrasound Diagnostics, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, Shaanxi, China)
关键词:
超声检测; 肥胖症; 血管阻力; 血量; 脂肪组织
Keywords:
ultrasonography;  obesity;  vascular resistance;  blood flow;  adipose tissue
分类号:
Q591.5
DOI:
-
文献标识码:
A
摘要:
目的 探讨健康青年脂肪分布特征对全身重要脏器血流的影响。方法 49例青年健康志愿者，根据标准分为非超重组和超重组。超声法测量腹部及肢体脂肪厚度，计算心排出量及各部位血流量，记录血管阻力。结果 男性内脏脂肪较女性明显厚〔(5.0±0.4)cm vs.(3.2±0.2)cm，P<0.01〕，腿部脂肪较女性明显薄〔(0.8±0.1)cm vs.(1.4±0.1)cm，P<0.01〕，腰臀比较女性大〔(0.90±0.01) vs.(0.83±0.01)，P<0.01〕。虽然腰臀比与大腿血流量和上肢血流量显著相关，但这种相关性在男组和女组内部并不存在。超重组青年心排出量明显增多，男性超重组脑血流量增多〔(0.84±0.17)L/min vs. (1.05±0.22)L/min,P<0.05〕，脑血管阻力下降〔椎动脉：(0.66±0.10) vs.(0.57±0.07)，P<0.05〕。女性超重组所有检测血流指标均数均高于非超重组，但无显著差别。结论 健康青年，脂肪分布对全身重要脏器的血流分布影响不显著。
Abstract:
AIM To investigate the influence of fat distribution on the blood flow distribution of major organs in healthy young subjects. METHODSForty-nine young healthy volunteers were divided into two groups: normal weight group (BMI<24, n=27) and overweight group (BMI≥24, n=22). Visceral and subcutaneous fat were measured by ultrasound. Cardiac output and blood flow volume distributed to the brain, abdomen and limbs were calculated. Peripheral arterial resistance index was acquired. RESULTSIn males, visceral fat was thicker ［(5.0±0.4) cm vs.(3.2±0.2) cm, P<0.01］ and waist to hip ratio (W/H ratio) was higher (0.90±0.01 vs. 0.83±0.01, P<0.01) compared with those in females. Although W/H ratio was significantly correlated with blood flow to the limbs, no such correlation was found in males or females. Cardiac output was remarkably increased in overweight group and cerebral blood flow volume was significantly increased in overweight males compared with those in non-overweight males ［(0.84±0.17) l/min vs.(1.05±0.22) l/min, P<0.05］. Vertebral arterial resistance index was decreased (0.66±0.10 vs. 0.57±0.07, P<0.05). CONCLUSIONFat distribution exerts no obvious effect on blood flow of major organs in young healthy subjects.

参考文献/References

[1]Rosen ED,Spiegelman BM.Adipocytes as regulators of energy balance and glucose homeostasis[J].Nature,2006,444(7121):847-853.
[2]Fox CS,Massaro JM,Hoffmann U,et al.Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study[J].Circulation,2007,116(1):39-48.
[3]Neeland IJ,Ayers CR,Rohatgi AK,et al.Associations of visceral and abdominal subcutaneous adipose tissue with markers of cardiac and metabolic risk in obese adults[J].Obesity (Silver Spring),2013,21(9):E439-E447.
[4]Bertoli S,Leone A,Vignati L,et al.Metabolic correlates of subcutaneous and visceral abdominal fat measured by ultrasonography:a comparison with waist circumference[J].Nutrition journal,2016,15(1):2.
[5]Siervo M,Lara J,Celis-Morales C,et al.Age-related changes in basal substrate oxidation and visceral adiposity and their association with metabolic syndrome[J].Eur J Nutr,2015,80(4):406-413
[6]Mizrahi I,Beglaibter N,Simanovsky N,et al.Ultrasound evaluation of visceral and subcutaneous fat reduction in morbidly obese subjects undergoing laparoscopic gastric banding, sleeve gastrectomy, and Roux-en-Y gastric bypass:a prospective comparison study[J].Obesity surgery,2015,25(6):959-966.
[7]Midorikawa T,Ohta M,Hikihara Y,et al.Prediction and validation of total and regional fat mass by B-mode ultrasound in Japanese pre-pubertal children[J].The British journal of nutrition,2011,106(6):944-950.
[8]胡咏梅,武晓洛,胡志红,等.关于中国人体表面积公式的研究[J].生理学报,1999,51(1):45-48.
[9]Wajchenberg BL.Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome[J].Endocrine reviews,2000,21(6):697-738.
[10]Koutsari C,Ali AH,Mundi MS,et al.Storage of circulating free fatty acid in adipose tissue of postabsorptive humans:quantitative measures and implications for body fat distribution[J]. Diabetes,2011,60(8):2032-2040.
[11]Ibrahim MM.Subcutaneous and visceral adipose tissue:structural and functional differences[J].Obes rev,2010,11(1):11-18.
[12]Kapur VK,Wilsdon AG,Au D,et al.Obesity is associated with a lower resting oxygen saturation in the ambulatory elderly:results from the cardiovascular health study. Influence of obesity on nocturnal oxygen saturation in young children.Effect of obesity and glycated hemoglobin on oxygen saturation in ambulatory type 2 diabetic individuals:A pilot study[J].Respir Care,2013,58(5):831-837.
[13]Sakuno T,Tomita LM,Tomita CM,et al.Sonographic evaluation of visceral and subcutaneous fat in obese children[J].Radiologia brasileira,2014,47(3):149-153.

备注/Memo

备注/Memo:
收稿日期：2016-03-01.
基金项目：国家自然科学基金项目资助（81370275）
通讯作者：袁丽君，教授，主要从事心血管超声及血流动力学研究 Email：yuanlj@fmmu.edu.cn
作者简介：马婧，硕士生 Email：majingcwx@163.com
更新日期/Last Update: 2016-04-13