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|本期目录/Table of Contents|

ANGPTL2表达与急性冠脉综合征患者的关联性及其意义

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2017年第1期
页码:
52-054,059
栏目:
临床研究
出版日期:
2016-10-05

文章信息/Info

Title:
Association and significance of ANGPTL2 and patients with acute coronary syndrome
作者:
郭玲玉; 陈一竹; 杨文龙; 张明亮; 周 璇; 许盛松; 张俊峰
(上海交通大学医学院附属第三人民医院心内科，上海 201999)
Author(s):
GUO Ling-yu;  CHEN Yi-zhu;  YANG Wen-long;  ZHANG Ming-liang;  ZHOU Xuan;  XU Sheng-song;  ZHANG Jun-feng
(Department of Cardiology, Third People’s Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 201999, China)
关键词:
急性冠脉综合征; 血管生成素样蛋白2; 血小板; 血栓
Keywords:
acute coronary syndrome;  angiopoietin-like protein 2;  platelet;  thrombus
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 探讨血管生成素样蛋白(angiopoietinlike protein,ANGPTL)2表达与急性冠脉综合征（ACS）患者的关联性及其意义。方法 冠心病患者121例分为2组：ACS组〔88例，其中ST段抬高型急性心肌梗死（STEMI） 48例，非ST段抬高型急性冠脉综合征（NSTE-ACS）40例〕和稳定型心绞痛（SAP）组（33例）。收集外周血血浆，采用酶联免疫吸附试验检测ANGPTL2的浓度；抽吸获得STEMI患者的冠脉血栓，免疫组化SABC法检测ANGPTL2在冠脉血栓中的表达情况。结果 ANGPTL2血浆浓度在ACS组显著高于SAP组（P<0.01），并且在STEMI组也显著高于NSTE-ACS组（P<0.01）。多因素回归分析显示，ANGPTL2为ACS的独立相关因素（OR=3.15，95%CI，1.64-6.02，P<0.01）。ANGPTL2在STEMI患者的冠脉血栓中高表达。结论 ANGPTL2在ACS患者中高表达是ACS患者的独立相关因素，也可能与血小板成栓有密切关系。
Abstract:
AIM To investigate the significance and association of angiopoietin-like protein 2 (ANGPTL2) in acute coronary syndrome (ACS) patients. METHODSOne hundred and twenty-one subjects were recruited and were divided into ACS group ［n=88 patients, including 48 patients with ST-segment elevation myocardial infarction (STEMI) and 40 patients with non-ST elevation acute coronary syndrome (NSTE-ACS)］ and stable angina pectoris (SAP) group (n=33). Peripheral blood plasma was collected and enzyme-linked immunosorbent assay was used to test the concentration of ANGPTL2. Aspiration was used to obtain coronary thrombus in STEMI patients and ANGPTL2 expression was detected by SABC immunohistochemical method. RESULTSPlasma ANGPTL2 levels in ACS patients were significantly higher than in SAP patients (P<0.01). Plasma ANGPTL2 levels in patients with STEMI were significantly higher than those in patients with NSTE-ACS (P<0.01). Multivariate analysis showed that ANGPTL2 was an independent risk factor of ACS. In addition, ANGPTL2 was highly expressed in coronary thrombus. CONCLUSIONHigh expression of ANGPTL2 in ACS patients is an independently associated factor and may have a close relationship with platelet thrombus.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2015-12-14.基金项目：上海市自然科学基金资助(16ZR1419900)
通讯作者：张俊峰，主任医师，主要从事冠心病防治研究 Email：jfzhang_dr@163.com
作者简介：郭玲玉，硕士生 Email：lyguo_guoguo@163.com
更新日期/Last Update: 2016-10-09