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《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:

2017年第1期

页码:

83-085

栏目:

临床研究

出版日期:

2016-10-05

文章信息/Info

Title:

Influence and analysis of blood pressure in young soldiers with first-stage hypertension during plateau encampment

作者:

蔡晓庆¹; 焦丕奇¹; 剡冬冬¹; 李 榕¹; 李淑红¹; 向大伟²; 陈永清¹

（兰州军区兰州总医院：1.心血管内科，2.医务部，甘肃 兰州 730050）

Author(s):

CAI Xiao-qing¹;  JIAO Pi-qi¹;  YAN Dong-dong¹;  LI Rong¹;  LI Shu-hong¹;  XIANG Da-wei²;  CHEN Yong-qing¹

(1.Department of Cardiology, 2.Department of Medical Administration, Lanzhou General Hospital, Lanzhou Military Area Command, Lanzhou 730050, Gansu, China)

关键词:

高血压; 原发性; 高原; 高寒; 肾素-血管紧张素-醛固酮系统

Keywords:

essential hypertension;  plateau;  cold areas;  renin-angiotensin-aldosterone system

分类号:

R544.1

DOI:

-

文献标识码:

A

摘要:

目的 研究高原高寒地区短期驻训对罹患高血压Ⅰ级青年官兵血压的影响并分析其可能机制。方法 测定13名高血压Ⅰ级青年官兵基础血压和高原驻训期间血压和心率（驻训10 ，30，60 d），并采集相应时间点血样检测血管紧张素Ⅰ、血管紧张素Ⅱ、醛固酮和皮质醇水平。结果 进驻高原10 d后官兵收缩压和舒张压均较基线水平显著升高（P<0.05），此后驻训30 d和驻训60 d患者收缩、舒张压数值均高于基线水平（P<0.05）。比较驻训高原前后全天平均心率未见组间明显差异。分析机制发现，高原驻训10 d起血管紧张素Ⅰ和血管紧张素Ⅱ水平均较驻训前显著升高（P<0.05），且此后持续高于驻训前水平（P<0.05），而血清醛固酮和皮质醇水平在驻训60 d时较驻训前显著升高（P<0.05）。结论 高原高寒环境作为应激刺激会导致高血压1级青年官兵血压出现持续升高，其机制可能与肾素-血管紧张素-醛固酮系统激活及应激激素水平升高相关。

Abstract:

AIM To investigate the influence of blood pressure (BP) on young soldiers with first-stage hypertension during plateau encampment and to analyze the underlying mechanisms. METHODSBP of 13 young soldiers with first-stage hypertension was recorded at different time points (before arriving at plateau and 10 days, 30 days, 60 days after plateau encampment) and blood samples at corresponding time points were obtained for analysis of hormone levels. RESULTSBP on 11th, 31st and 61st day of plateau encampment was significantly higher than baseline (P<0.05). Hormone levels of angiotensin II were consistently higher than baseline from the 11th day of plateau encampment, and aldosterone and cortisol contents were significantly higher on the 61st day of encampment than at baseline. CONCLUSIONDuring plateau encampment, high blood pressure of soldiers suffering first-stage hypertension deteriorates, which is probably related to activation of the renin-angiotensin-aldosterone system and elevation of stress hormone levels.

参考文献/References

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备注/Memo

备注/Memo:

收稿日期: 2015-12-29.基金资助：军队保健专项课题资助（14BJZ25）
通讯作者：陈永清，主任医师，主要从事高血压和介入心血管病学研究 Email：chyqmd@163.com
作者简介：蔡晓庆，主治医师，硕士 Email：xiaoqcai6@126.com

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更新日期/Last Update: 2016-10-09