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|本期目录/Table of Contents|

诱导多能干细胞与转分化在心肌再生中的研究进展

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2017年第1期
页码:
109-111,115
栏目:
综述
出版日期:
2016-10-05

文章信息/Info

Title:
Pluripotent stem cells and transdifferentiation in myocardial regeneration: an overview
作者:
李 天1; 邹远康1; 李子超1; 付志猛1; 董芊芊1; 2; 杨 倩2; 张海锋1
（第四军医大学：1.教学实验中心，2.药学系天然药物学教研室，陕西 西安710032）
Author(s):
LI Tian1;  ZOU Yuan-kang1;  LI Zi-chao1;  FU Zhi-meng1;  DONG Qian-qian1; 2;  YANG Qian2;  ZHANG Hai-feng1
(1.Experimental Teaching Center, 2.Department of Natural Medicine, School of Pharmacy, Fourth Military Medical University, Xi’an 710032, Shaanxi, China)
关键词:
诱导多能干细胞; 转分化; 心肌再生; 心肌梗死
Keywords:
induced pluripotent stem cells;  transdifferentiation;  myocardial regeneration;  myocardial infarction
分类号:
R394
DOI:
-
文献标识码:
A
摘要:
以往认为，心肌受损后，心肌细胞不能再生，常由瘢痕组织修复，从而使心脏失去结构与功能上的完整性。随着心肌再生机制研究的不断深入和转化医学的发展，已证实在一定条件下，心肌能够再生并产生正常的心肌细胞，并已逐渐成为临床上心肌损伤修复的研究热点。本文对诱导多能干细胞（induced pluripotent stem cell,iPSC）与转分化在心肌再生领域的研究进展做一综述，旨在为心肌再生的临床治疗提供新的思路。
Abstract:
Myocardium is usually repaired by scar tissue after myocardial ischemia. Because myocardium was thought incapable of regenerating cardiomyocytes, it is thus deprived of structural and functional integrity. With the advancement of research on myocardial regeneration and translational medicine, it has been confirmed that myocardium, a new popular research topic for the treatment of myocardial ischemia, can continually generate normal cardiomyocytes. This article provides an overview of induced pluripotent stem cells (iPSC) and transdifferentiation in myocardial regeneration and introduces some new ideas for the clinical treatment of myocardial regeneration.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2015-12-14.基金项目：国家自然科学基金项目资助（81270330，81500192）
通讯作者：张海锋，副教授，主要从事心脏保护方面研究 Email:hfzhang@fmmu.edu.cn
作者简介：李天，硕士生 Email:1151953246@qq.com
更新日期/Last Update: 2016-10-09