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|本期目录/Table of Contents|

大样本冠状动脉慢血流的相关因素分析(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2017年第2期
页码:
180-183
栏目:
临床研究
出版日期:
2016-11-25

文章信息/Info

Title:
Analysis of risk factors for slow coronary flow in 958 patients
作者:
王 帅1; 2; 薛 强1; 刘 毅1; 关 欣1; 陶 凌1
（1.第四军医大学西京医院心血管内科，陕西 西安 710032；
2.解放军第205医院心血管内科,辽宁 锦州 121000）
Author(s):
WANG Shuai1; 2;  XUE Qiang1;  LIU Yi1;  GUAN Xin1;  TAO Ling1
(1.Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, Shaanxi, China；
2.Department of Cardiology, PLA 205 Hospital, Jinzhou 121000, Liaoning, China)
关键词:
冠状动脉慢血流; 冠状动脉造影; 相关因素; 多因素回归分析
Keywords:
Slow coronary flow;  coronary angiography;  risk factors;  multivariate logistic regression
分类号:
R543.3；R339.5
DOI:
-
文献标识码:
A
摘要:
目的 探讨冠状动脉慢血流(slow coronary flow，SCF)现象的相关因素。方法 回顾西京医院心内科2006年9月~2015年6月冠脉造影的患者85 668例，将冠脉血流仅为TIMI II级或以下的定义为SCF(SCF组，n=958)，选取同时期冠状动脉血流正常患者为对照组(n=507)，多因素分析采用Logistic回归分析。结果 SCF组男性比例、吸烟率、吸烟指数、白细胞计数、血红蛋白浓度、高密度脂蛋白胆固醇、血清载脂蛋白A1、血清载脂蛋白B、超敏C反应蛋白、胱抑素C均显著高于对照组，差异具有统计学意义（P<0.05或P<0.01）。多因素Logistic回归分析结果显示，性别（OR=15.119,95%CI 4.854-47.096,P<0.05）,年龄(OR=0.934,95%CI 0.879-0.974,P<0.05),心率(OR=1.045,95%CI 1.01-1.081，P<0.05),吸烟指数(OR=1.002,95%CI 1.0-1.003,P<0.01),血清载脂蛋白A1(OR=14.472,95%CI 5.446-38.455,P<0.05),为SCF的独立相关因素。结论 性别、年龄、心率，吸烟指数、血清载脂蛋白A1降低为本地区SCF的独立相关因素。
Abstract:
AIM To investigate the risk factors for slow coronary flow (SCF) phenomenon. METHODS We retrospectively analyzed 85,668 patients undergoing coronary angiography from September 2006 to June 2015. Patients with normal TIMI flow were selected as control. SCF was defined as TIMI flow 2. Logistic regression was used to analyze the risk factors of SCF. RESULTS Nine hundred and fifty-eight patients demonstrated SCF and the incidence of SCF was 1.1%. In patients with SCF, there were more smokers, lower heart rate and higher HDL, Apo-A1, Apo-B, cystatin C and C-reactive protein (CRP) serum concentration compared with those in patients with non-SCF (P<0.05, P<0.01). Using multivariate logistic regression analysis, we found that gender (OR=15.119, 95%CI 4.854-47.096, P<0.05), age (OR=0.934, 95% CI 0.879-0.974, P<0.05), smoking index (OR=1.002, 95%CI 1.0-1.003, P<0.01), heart rate (OR=1.045, 95%CI 1.01-1.081, P<0.05) and Apo-A1 (OR=14.472, 95%CI 5.446-38.455, P<0.05) were independent predictors of SCF. CONCLUSION Male, older age, smoking index, lower heart rate, reduced Apo-A1 and increased CRP are independent predictors of SCF.

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备注/Memo

备注/Memo:
收稿日期：2016-05-16.
通讯作者：陶凌，主任医师，主要从事冠心病诊断与治疗研究Email:lingtao@fmmu.edu.cn
作者简介：王帅，住院医师，硕士生 Email:shellywang17@qq.com 共同第一作者：薛强，主治医师 Email:270625777@qq.com
更新日期/Last Update: 2016-10-11