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老年钙化性主动脉瓣狭窄与冠心病的关系(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2017年第2期
页码:
192-194,197
栏目:
临床研究
出版日期:
2016-11-25

文章信息/Info

Title:
Relationship between senile calcific aortic stenosis and coronary heart disease
作者:
孙仕怀1; 王琦光2; 朱鲜阳2; 崔春生2; 孟立立2; 王建铭2; 魏 鑫1
（1.辽宁医学院心内科，辽宁 锦州 121001；
2.沈阳军区总医院先心病内科，辽宁 沈阳 110016）
Author(s):
SUN Shi-huai1;  WANG Qi-guang2;  ZHU Xian-yang2;  CUI Chun-sheng2;  MENG Li-li2;  WANG Jian-ming2;  WEI Xin1
(1.Department of Cardiology, Liaoning Medical University, Jinzhou 121001, Liaoning, China；
2.Department of Congenital Heart Disease, General Hospital, Shenyang Military Area Command, Shenyang 110016, Liaoning, China)
关键词:
主动脉瓣狭窄; 钙化性; 冠状动脉疾病; 危险因素
Keywords:
calcification;  aortic stenosis;  coronary heart disease;  angina;  risk factor
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 探讨老年钙化性主动脉瓣狭窄（senile calcific aortic stenosis，SCAS）与冠心病的关系。方法 收集沈阳军区总医院收治的SCAS患者173例。所有患者均行常规检查与冠状动脉造影检查，明确冠脉病变并行Gensini评分，进行相关统计分析。结果 将所有患者按跨主动脉瓣平均压差分为轻、中、重3组。经冠脉造影检查明确29例并发冠心病，冠心病阳性率在动脉粥样硬化(AS)重度狭窄组为25%>AS中度狭窄组(16%)>AS轻度狭窄组(8%)。3组间冠心病阳性率存在显著差异（P<0.05），具有统计学意义。此外，3组平均Gensini评分分别为0.906、1.430和5.905，随着主动脉瓣狭窄程度的增加，评分也具有增加趋势，表明二者具有相关性。结论 SCAS与冠心病间存在相关性。
Abstract:
AIM To explore the relationship between senile calcific aortic stenosis (SCAS) and coronary heart disease (CHD). METHODS One hundred and seventy-three patients with SCAS in our hospital were enrolled. Each patient underwent routine examination and coronary angiography. To identify the condition of the coronary artery and Gensini score, statistical analysis was performed. RESULTS Among the 173 patients, 78 were males and 95 females, aged 60-77 years (65.67±6.6 years). Patients were divided into three groups: mild, moderate and severe SCAS according to the average transvalvular pressure of aortic valve. There were 29 patients with CHD according to the results of coronary angiography. The positive rates of CHD in the severe SCAS group, moderate SCAS group and mild SCAS group were 25%, 16%, and 8%, respectively, with statistical difference among the three groups (P=0.036). Average Gensini scores in the mild SCAS group, moderate SCAS group and SCAS severe group were, respectively, 0.906, 1.430 and 5.905, increasing with the higher degree of SCAS. CONCLUSION There is a relationship between SCAS and CHD. The positive rate and severity of CHD have an increasing tendency with the increase in the degree of SCAS.

参考文献/References

[1]Helske S,Kupari M,Lindstedt KA.Aortic valve stenosis: an active atheros inflammatory process[J].Curr Opin Lipidol, 2007,18(5):483-491.
[2]沈文锦.重视老年钙化性主动脉瓣狭窄的防治研究[J].心脏杂志,2014,26(6):621-624.
[3]Aronow WS,Ahn C,Shirani J,et al.Comparision of new coronary events in older persons with mild, moderate and severe valvular aortic stenosis with those without aortic stenosis[J].Am J Cardiol,1998,81(5):647-649.
[4]Saladze T,Gogiashvili L,Tsagareli Z,et al.Histological and Immunohistochemical Studies of Atherosclerotic and Senile Calcificaortic Valve Stenosis[J].Georgian Med News,2015,(244-245):94-99.
[5]Osnabrugge RL,Mylotte D,Head SJ,et al.Aortic Valve Replacement:A Meta-Analysis and Modeling Study[J].J Am Coll Cardiol,2013,62(11):1002-1012.
[6]Gensini GG.A more meaningful scoring system for detemining the severity of coronary heart disease[J].Am J Cardiol,1983,51:606
[7]Rosenhek R,Binder T,Porenta G,et al.Predictors of outcomes in severe,asymptomatic aortic stenosis[J].N Engl J Med,2000,343(9):611-617.
[8]Pohle K,Maffert R,Ropers D,et al.Progression of aortic valve calcification:association between coronary atherosclerosis and cardiovascular risk factors[J].Circulation,2001,104(16):1927-1932.
[9]Goldbarg S,Elmariah S,Marc A,et al.Insights into degenera-tive aortic valve disease[J].Journal of the American College of Cardiology,2007,50(13):1205-1213.
[10]Ahn JH,Kim SM,Park SJ,et al.Coronary microvascular dysfunction as a mechanism of angina in severe AS[J].J Am Coll Cardiol,2016,67(12):1412-1422.
[11]Thompson RH,Ahmed MS,Mitchell AG,et al.Angina, aortic stenosis and coronary heart disease[J].Clin Cardiol,1979,2(1):26-32.

备注/Memo

备注/Memo:
收稿日期：2016-01-26.
通讯作者：王琦光,副主任医师，主要从事先天性心脏病和介入治疗研究 Email：wqg1993@163.com
作者简介：孙仕怀，主治医师，硕士 Email：814699786@qq.com
更新日期/Last Update: 2016-10-11