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成纤维细胞生长因子23多态性与小儿川崎病患者心血管病变易感性的关系(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2017年第2期
页码:
210-212
栏目:
临床研究
出版日期:
2016-11-25

文章信息/Info

Title:
Fibroblast growth factor 23 gene polymorphism in children with Kawasaki syndrome and susceptibility to cardiac abnormalities
作者:
罗 君1; 龙 芳2; 王菊艳3; 王海成4
（汉中市中心医院：1.儿科，2.医务科，陕西 汉中 723000；
3.陕西省人民医院儿科，陕西 西安 710068；
4.西安交通大学第一附属医院心内科，陕西 西安 710061）
Author(s):
LUO Jun1;  LONG Fang2;  WANG Ju-yan3;  WANG Hai-cheng4
(1.Department of Pediatrics, 2.Medical Department, Hanzhong Central Hospital, Hanzhong 723000, Shaanxi, China；
3.Department of Pediatrics, Shaanxi People’s Hospital, Xi’an 710068, Shaanxi, China；
4.Department of Cardiology, First Affiliated Hospital of Xi’an Jiao Tong University, Xi’an 710061, Shaanxi, China)
关键词:
成纤维细胞生长因子23; 儿童; 川崎病; 易感性; 心脏病
Keywords:
fibroblast growth factor 23;  children;  Kawasaki disease;  susceptibility;  heart attack
分类号:
R442.8
DOI:
-
文献标识码:
A
摘要:
目的 探讨川崎病患儿成纤维细胞生长因子(FGF)-23基因多态性、血清表达水平及对心脏病易感性的影响。方法 选取2013年1月~2015年1月我院收治的90例川崎病患儿，检测90例患儿的FGF-23基因内含子多态性及心脏病的发生情况，根据患儿FGF-23的不同基因型将其分成FGF-23基因多态性组和FGF-23基因野生型组，比较两组患儿的血清FGF-23水平、血清相关指标及心脏病变易感性。结果 本研究90例川崎病患儿中，FGF-23基因野生性组患儿64例，所占比例为71%，FGF-23基因多态性组患儿26例，所占比例为29%；FGF-23基因多态性组男性比例及血清FGF-23水平〔92%，（41±15）ng/L〕显著高于对照组〔62%，（11±13） ng/L，P<0.05〕；FGF-23基因多态性组患儿冠状动脉扩张、冠状动脉瘤以及心脏受累发生率均显著高于FGF-23基因野生性组（P<0.05）；Logistic回归多因素分析发现血清FGF-23水平与川崎病患儿心血管病变的发生率显著相关（P<0.01）。结论 FGF-23基因多态性的川崎病患者血清FGF-23水平显著增高，且冠状动脉异常几率增大。
Abstract:
AIM To investigate genetic variations in the FGF-23 gene in children with Kawasaki syndrome and its association with serum FGF-23 levels and eventual development of cardiac abnormalities. METHODS Ninety children with Kawasaki disease (from January 2013 to January 2015) in our hospital were selected for this study and FGF-23 gene intron polymorphism and incidence of heart disease were examined. According to different genotypes of FGF-23, 90 cases were divided into FGF-23 gene polymorphism group and FGF-23 gene wild-type group.Serum FGF-23 level, serum-related indicators and susceptibility of heart attack were compared between groups. RESULTS Of the 90 cases, 64 cases had the FGF-23 wild-type genotype (71%) and 26 had the FGF-23 gene polymorphism (29%). The proportion of males and serum FGF-23 levels in FGF-23 gene polymorphism group were significantly higher than those in FGF-23 wild-type gene group ［92%, (41±15) pg/ml vs. 62%, (11±13) pg/ml; P<0.05］. The incidence of coronary aneurysms or dilatation in the FGF-23 gene polymorphism group was significantly higher than in the wild-type FGF-23 gene group (P<0.05). CONCLUSION Serum FGF-23 levels of patients with Kawasaki disease and FGF-23 gene polymorphism are significantly increased and the risk of coronary artery abnormalities is increased.

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备注/Memo

备注/Memo:
收稿日期：2016-01-22.
作者简介：罗君，主治医师 Email：lujun19730126@126.com
更新日期/Last Update: 2016-10-11