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中性粒细胞胞外诱捕网与心血管疾病(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2017年第2期
页码:
232-235
栏目:
综述
出版日期:
2016-11-25

文章信息/Info

Title:
Neutrophil extracellular traps and cardiovascular diseases
作者:
王利秀; 佟春芝; 马国力; 张 妍; 毕亚艳
（哈尔滨医科大学附属第一医院心内科，黑龙江 哈尔滨150001）
Author(s):
WANG Li-xiu;  TONG Chun-zhi;  MA Guo-li;  ZHANG Yan;  BI Ya-yan
(Department of Cardiology, First Affiliated Hospital, Harbin Medical University, Harbin 150001, Heilongjiang, China)
关键词:
中性粒细胞胞外诱捕网; 抗炎; 促凝; 心血管疾病
Keywords:
neutrophil extracellular traps;  anti-inflammation;  pro-coagulation;  cardiovascular diseases
分类号:
R446.6
DOI:
-
文献标识码:
A
摘要:
中性粒细胞胞外诱捕网（NETs）是中性粒细胞活化或凋亡时释放的一种具有多种生物学活性的网状结构。随着NETs生成和作用机制的阐明，已发现其具有抗炎、促凝、抗凝及加重血管内皮功能障碍等作用。心血管疾病的发生与炎症反应、血液高凝状态等有关。早期检测NETs可能对某些心血管疾病的预防和治疗有重要意义。本文就NETs及其与心血管疾病关系的研究进展进行综述。
Abstract:
Neutrophil extracellular traps are trap structures released from neutrophils upon activation or apoptosis and have many biological activities. With the understanding of the generation and action mechanism of neutrophil extracellular traps, studies have found that neutrophil extracellular traps have anti-inflammatory, procoagulant and anti-procoagulant effects and aggravate endothelial dysfunction. The occurrence of cardiovascular diseases is associated with inflammation and blood hypercoagulability. Early detection of neutrophil extracellular traps might be of great significance in the prevention and treatment of some cardiovascular diseases. In this review we primarily summarized the current development of neutrophil extracellular traps as well as the relationship of neutrophil extracellular traps and cardiovascular diseases.

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备注/Memo

备注/Memo:
收稿日期：2015-11-04.
基金项目：黑龙江省自然科学基金项目资助（H201347）
通讯作者：毕亚艳，主任医师，主要从事冠心病防治研究 Email：biyayan@163.com
作者简介：王利秀，硕士生 Email：13836112853@163.com
更新日期/Last Update: 2016-10-11