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肌浆网钙泄漏在心脏功能不全中的作用(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2017年第2期
页码:
246-250
栏目:
综述
出版日期:
2016-11-25

文章信息/Info

Title:
Sarcoplasmic reticulum calcium leak and its role in cardiac dysfunction
作者:
李松声1; 马超群1; 王倩倩2; 肖 良2
（第二军医大学海军医学系：1.海军临床医学专业2012级，2.海洋生物技术教研室，上海 200433）
Author(s):
LI Song-sheng1;  MA Chao-qun1;  WANG Qian-qian2;  XIAO Liang2
(1.Grade 2012, Naval Clinical Medicine, 2.Department of Marine Biotechnology, Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433, China)
关键词:
肌浆网; Ca2+; 兰尼碱受体; 心律失常; 心力衰竭
Keywords:
sarcoplasmic reticulum;  Ca2+;  ryanodine receptor;  arrhythmia;  heart failure
分类号:
R329.4
DOI:
-
文献标识码:
A
摘要:
同步肌浆网Ca2+释放以外的Ca2+释放即肌浆网Ca2+泄漏（Ca2+ leak），包括Ca2+火花（Ca2+ spark）、自发性Ca2+波（spontaneous Ca2+ wave）和其他微小Ca2+释放等。心肌细胞肌浆网Ca2+泄露主要是由II型兰尼碱受体（ryanodine receptor 2,RyR2）介导的，它可以通过减少肌浆网Ca2+的有效释放导致心脏收缩功能障碍；通过升高舒张期胞浆Ca2+引发心脏舒张功能不全，诱发心律失常。此外，肌浆网Ca2+泄露还可以引起因肌浆网Ca2+回摄增多消耗更多的ATP，导致心律失常、心力衰竭等心脏疾病的进一步恶化。
Abstract:
Sarcoplasmic reticulum (SR) Ca2+ leak is defined as SR Ca2+ release other than that during the active excitation-contraction coupling process, which includes Ca2+ sparks and waves as well as smaller Ca2+ events. SR Ca2+ leak can reduce SR Ca2+ available for release, causing systolic dysfunction and elevate diastolic ［Ca2+］i, contributing to diastolic dysfunction and arrhythmias. Moreover, SR Ca2+ leak is energetically costly because of the extra ATP used to re-pump Ca2+, leading to further deterioration of RyR2-related heart diseases such as arrhythmias and heart failure.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2015-10-16.
基金项目：国家自然科学基金面上项目资助（81470518）；第二 军医大学大学生创新能力培养计划资助(MS2015025)
通讯作者：肖良，讲师，主要从事心脏兴奋收缩偶联机制研究 Email:hormat830713@hotmail.com
作者简介：李松声，本科生 Email:angeliqueur@hotmail.com
更新日期/Last Update: 2016-10-11