新型抗栓药物替格瑞洛在急性冠脉综合征治疗中的应用研究进展
《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]
- 期数:
- 2017年第5期
- 页码:
- 605-609,613
- 栏目:
- 综述
- 出版日期:
- 2017-03-25
文章信息/Info
- Title:
- Research progress in application of new antithrombtic drug Ticagrelor in treatment of acute coronary syndrome
- Author(s):
- ZHANG Liang1; YUAN Ming1; CAO Feng2
- (1.Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, Shaanxi, China；
2.Department of Cardiology, PLA General Hospital, Beijing 100853, China)
- Keywords:
- ticagrelor; acute coronary syndrome; research progress
- 分类号:
- R543.3
- DOI:
- -
- 文献标识码:
- A
- 摘要:
- 急性冠脉综合征（ACS）是威胁人类健康的重大疾病。双联抗血小板治疗是ACS患者治疗的基石。氯吡格雷作为经典的抗血小板药物，在临床应用的过程中显现出许多不足，替格瑞洛由于其特殊的药代动力学和药效学特征，克服了氯吡格雷的缺陷，国内外许多大型临床研究已经证实在治疗ACS患者中的优越性，极大地降低了ACS患者的主要不良心血管事件。新的研究不断问世，为替格瑞洛提供了大量的循证医学证据。本文将对替格瑞洛的药理学特征、目前的临床研究及相应的指南作一综述。
- Abstract:
- Acute coronary syndrome (ACS) is a severe disease which threatens human health. Dual antiplatelet is the cornerstone of the treatment of ACS. Clopidogrel, as a classical antiplatelet drug, has showed several flaws. However,Ticagrelor, a new antithrombtic drug, overcomes those deficiencies thanks to its special pharmacokinetic and pharmacodynamics characteristics. Many large clinical studies have confirmed the advantages of Ticagrelor in treatment of ACS patients with acute coronary syndrome as it greatly reduces the major cardiac events in ACS patients. New studies have provided a large number of evidence-based medical evidence and this paper is to review the pharmacological characteristics, current clinical studies and corresponding guidelines of Ticagrelor.
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备注/Memo
- 备注/Memo:
- 收稿日期：2016-05-23.
基金项目：陕西省科技攻关计划课题资助(S2016 YFSF0666)
通讯作者：袁铭，副教授，主要从事冠心病的基础及复杂冠脉介入治疗 Email:yuanming@fmmu.edu.cn 共同
通讯作者：曹丰，教授，主要从事冠心病的诊断和治疗及心血管分子影像学研究 Email:fengcao8828@163.com
作者简介：张亮，硕士生 Email:zhangliang199096@163.com
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