我们的网站为什么显示成这样？

可能因为您的浏览器不支持样式，您可以更新您的浏览器到最新版本，以获取对此功能的支持，访问下面的网站，获取关于浏览器的信息：

|本期目录/Table of Contents|

原发性高血压患者醛固酮/肾素比值与夜间血压的关系

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2018年第1期
页码:
49-052
栏目:
临床研究
出版日期:
2017-10-10

文章信息/Info

Title:
Correlation study of aldosterone-to-renin ratio with nocturnal blood pressure in patients with essential hypertension
作者:
邓 敏1; 谢 勇1; 张秀菊1; 王大新2; 何胜虎1; 朱庆勇3; 徐日新1
（扬州大学临床医学院:1.苏北人民医院心内科，2.生物工程医学研究室，3.苏北人民医院心功能室，江苏 扬州 225001）
Author(s):
DENG Min1;  XIE Yong1;  ZHANG Xiu-ju1;  WANG Da-xin2;  HE Sheng-hu1;  ZHU Qing-yong3;  XU Ri-xin1
(1.Department of Cardiology, 3.Department of Electrocardiography, Subei people’s Hospital, 2.Biological Engineering Laboratory, Clinical Medicine College, Yangzhou University, Yangzhou 225001, Jiangsu, China)
关键词:
高血压; 原发性; 醛固酮; 夜间血压; 相关性
Keywords:
hypertension;  essential;  aldosterone;  nocturnal blood pressure;  correlation
分类号:
R544.1
DOI:
-
文献标识码:
A
摘要:
目的 探讨日常服用降压药的原发性高血压患者醛固酮/肾素比值（ARR）与夜间血压的相关性。方法 入选研究对象179（男88，女91）例，按ARR采用中位数（M）分为2组，比较2组的日间收缩压（DSBP）、日间舒张压（DDBP）、夜间收缩压（NSBP）、夜间舒张压（NDBP）以及在服药物、血钾、血钠等指标。结果 2组中NSBP、NDBP、血钾、血钠有显著性差异（均P<0.05，P<0.01），而性别、年龄、糖尿病、吸烟、体质量指数、DSBP、DDBP以及服用降压药物的差异均无统计学意义。同时校正了相关因素后，ARR与NSBP、NDBP、血钠呈正相关（r=0.528、r=0.481、r=0.342，均P<0.05），而与血钾呈负相关（r=-0.354，P<0.05）。多因素Logistic回归分析显示NSBP、NDBP均是ARR的独立相关因素（P<0.05），0R值分别为1.094（95%CI:0.906-1.205）、1.150（95%CI:0.919-1.445）。结论 原发性高血压患者中ARR与夜间血压显著相关。
Abstract:
AIM To study the correlation between aldosterone/renin ratio (ARR) and nocturnal blood pressure in patients with essential hypertension. METHODS According to diagnostic and screening criteria, the study included 179 people (88 male and 91 female). The ARR of all subjects, according to the median, were divided into two groups. Monitoring was performed of 24 hour ambulatory blood pressure, serum potassium, serum sodium and other electrolytes. Daytime systolic blood pressure (DSBP), daytime diastolic blood pressure (DDBP), nocturnal systolic pressure (NSBP), nocturnal diastolic pressure (NDBP), medications, serum potassium, serum sodium and other electrolytes were compared between the two groups. RESULTS There were significant differences between the two groups in NSBP, NDBP, blood potassium, sodium (P<0.05, P<0.01), while gender, age, diabetes mellitus, smoking, BMI, DSBP, DDBP, and medicines were not significantly different. After correcting related factors, ARR was positively correlated with DSBP, DDBP, serum sodium (r=0.528, r=0.481, r=0.342, all P<0.05), and negatively correlated with serum potassium (r=-0.354, P<0.05). Multivariate Logistic regression analysis revealed that NSBP and NDBP were independent risk factors for ARR P<0.05), and the 0R values were 1.094 (95%CI:0.906-1.205) and (95%CI:0.919-1.445), respectively. CONCLUSION In patients with essential hypertension, ARR is significantly correlated with nocturnal blood pressure.

参考文献/References

[1]Tomaschitz A,Maerz W,Pilz S,et al.Aldosterone/rennin ratio determines peripheral and central blood pressure values over a broad range[J].J Am Coll Cardio,2010,55(19):2171-2180.

[2]EL-Gharbawy AH,Nadig VS,Kotchen JM,et al.Arterial pressure, left ventricular mass ,and aldosterone in essential hypertension[J].Hypertension,2001,37(3):845-850.

[3]White WB,Calhoun DA,Krum H,et al.Blockade of aldosterone production as a novel approach to the management of high blood pressure:efficacy and tolerability of the aldosterone synthase inhibitor LCI699 in patients with stage 1-2 hypertension[J].J Am Coll Cardiol,2010,55(10):582.

[4]杨丽睿,孙 腾,张慧敏,等.难治性高血压患者阻塞性睡眠呼吸暂停综合征与醛固酮水平的相关性[J].中华高血压病杂志,2013,11(21):1028-1032.

[5] Martin R,Katharina K,Martin G,et al.Aldosterone to active renin ratio is associated with nocturnal blood pressure in obese and treated hypertension patients: The Styrian Hypertension Study[J].J Clin Hypertens,2014,16(4):289-294.

[6]Cho JS,Ihm SH,Jang SW,et al.Negative association between plasma aldosterone concentration/plasma renin activity and morning blood pressure surge in never-treated hypertensive patients[J].Clin Exp Hypertens,2014,36(4):195-199.

[7]张玉杰,李南方,张菊红,等.高血压患者中血浆醛固酮水平与左心室结构的相关性[J].中华心血管病杂志,2013,41(7):583-586.

[8]Scott L,Woodiwiss AJ,Maseko MJ,et al.Aldosterone-to-renin ratio and the relationship between urinary salt excretion and blood pressure in a community of African ancestry[J].Am J Hypertens,2011,24(8):951-957.

[9]郭艺芳,Stein PK,姚丽霞,等.血浆儿茶酚胺肾素醛固酮与血压的昼夜节律[J].中华心血管病杂志,2004,1(32):26-29.

[10]Ouvrard-Pascaud A,Sainte-Marie Y,Benitah JP,et al.Conditional mineralocorticoid receptor expression in the heart leads to life-threatening arrhythmias[J].Circulation,2005,111(23):3025-3033.

[11]Fraccarollo D,Berger S,Galuppo P,et al.Deletion of cardiomyocyte mineralocorticoid receptor ameliorates adverse remodeling after myocardial infarction clinical perspective[J].Circulation,2011,123(4):400-408.

备注/Memo

备注/Memo:
收稿日期：2017-01-02.通讯作者：谢勇，副教授，主要从事冠心病介入治疗研究 Email：dengm2046@sina.com 作者简介：邓敏，副教授，硕士 Email：dengm2046@sina.com
更新日期/Last Update: 1900-01-01