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|本期目录/Table of Contents|

冠心病患者Toll样受体4与冠脉病变严重程度的相关性

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2018年第1期
页码:
62-064
栏目:
临床研究
出版日期:
2017-10-10

文章信息/Info

Title:
Relationship between toll like receptors 4 and the severity of coronary artery lesion in patients with coronary heart disease
作者:
罗春艳1; 来春林2; 邢金平2; 赵建强2; 燕蒲娟1; 阮露芳1; 刘 慧1; 任 焰1
（1.山西医科大学；2.山西医科大学附属人民医院心内科，山西 太原 030012）
Author(s):
LUO Chun-yan1;  LAI Chun-lin2;  XING Jin-ping2;  ZHAO Jian-qiang2;  YAN Pu-juan1;  RUAN Lu-fang1;  LIU Hui1;  REN Yan1
(1.Shanxi Medical University, 2.Affiliated People’s Hospital of Shanxi Medical University, Taiyuan 030012, Shanxi, China)
关键词:
冠状动脉疾病; Toll样受体4; Syntax评分
Keywords:
coronary disease;  toll like receptors 4;  Syntax score
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 探讨冠心病患者Toll样受体（toll like receptors，TLR）4水平与冠状动脉（冠脉）病变严重程度的相关性。方法 选取我科住院经冠状动脉造影确诊为冠心病的患者141例。采用Syntax评分反映冠脉病变严重程度，根据Syntax评分结果分为低分(0~22分)61例、中分(23~32分)41例和高分(≥33分)39例。据此分为2组：Syntax低中分组(n=102)，Syntax高分组(n=39)。通过线性相关分析确定TLR4水平与冠脉病变严重程度的关系，通过多因素Logistic回归分析确定冠脉病变的相关因素。结果 与低中分组比较，高分组TLR4水平明显升高〔(93±24) vs.(128±29) ng/ml，P<0.01〕。TLR4水平与Syntax评分呈正相关(r=0.539,P<0.01)。多因素回归分析显示，TLR4水平是Syntax评分≥33分的相关因素(OR=15.645，95%CI：5.322-45.994；P<0.01）。结论 TLR4与冠脉病变严重程度密切相关，随着TLR4水平升高，冠脉病变越严重。
Abstract:
AIM To explore the relationship between toll like receptors 4 (TLR4) level and severity of coronary artery lesions in coronary heart disease patients. METHODS 141 patients with coronary heart disease participated in the study. The coronary heart disease group was divided into <33 Syntax score group (low-middle score group, n=102), and ≥33 Syntax score group (high score group, n=39). The correlation between TLR4 levels with Syntax score and risk factors were measured by linear correlation analysis and multivariate regression analysis, respectively. RESULTS Compared with the low-middle score group, TLR4 levels were significantly higher ［(93±24) vs.(128±29) ng/ml, P<0.01］ in high score group. TLR4 levels were positively related to Syntax score (r=0.539, P<0.01). Multivariate regression analysis revealed that TLR4 was independent to the Syntax score≥33 (OR=15.645, 95%CI:5.322-45.994; P<0.01). CONCLUSION TLR4 level is closely associated with severity of coronary artery 1esions.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2017-01-14.基金项目：山西省科技攻关项目资助(20120313018-8) 通讯作者：来春林，主任医师，主要从事动脉粥样硬化发病机制研究 Email：Lai0817@hotmail.com 作者简介：罗春艳，硕士生 Email：luochunyan521@163.com
更新日期/Last Update: 1900-01-01