我们的网站为什么显示成这样？

可能因为您的浏览器不支持样式，您可以更新您的浏览器到最新版本，以获取对此功能的支持，访问下面的网站，获取关于浏览器的信息：

|本期目录/Table of Contents|

冠心病并发重度牙周炎患者的SCD40L水平的观察研究

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2018年第1期
页码:
70-073
栏目:
临床研究
出版日期:
2017-10-10

文章信息/Info

Title:
Study on the level of SCD40L in patients with coronary heart disease complicated with severe periodontitis
作者:
孟晓雪1; 李 爽2; 周建业2
（1.兰州大学第一医院心内科，甘肃 兰州 730000；2.西北民族大学口腔医学院，甘肃 兰州 730030）
Author(s):
MENG Xiao-xue1;  LI Shuang2;  ZHOU Jian-ye2
（1.Department of Cardiology, The First Hospital of Lanzhou University, Lanzhou 730000,Gansu, China; 2.College of stomatology,Northwest University For Nationalities, Lanzhou 730030, Gansu, China）
关键词:
冠状动脉疾病; 牙周病; 可溶性CD40 配体
Keywords:
coronary disease;  periodontitis;  Soluble leukocyte surface antigens 40 ligand
分类号:
R541
DOI:
-
文献标识码:
A
摘要:
目的 观察可溶性CD40配体（SCD40L）与冠心病并发重度牙周炎患者疾病发生、发展的作用及其相关性。方法 选取受试对象63例分为健康对照组（n=14）、重度牙周炎组（n=16）、冠心病组（n=19）、冠心病并发重度牙周炎组（n=14）。 留取静脉血测定血清中SCD40L的浓度，观察各组中的表达水平。比较冠心病组及冠心病并发重度牙周炎组两组牙周参数〔探诊深度（PD）、附着丧失（CAL）、探诊后出血（BOP）、菌斑指数(PLI)及余留牙数目〕的不同。对SCD40L与PD、CAL、BOP、PLI进行相关性分析，观察SCD40L与各牙周参数是否存在相关性。 结果 与健康对照组比较，冠心病并发重度牙周炎组SCD40L明显升高（P<0.01）；与重度牙周炎组、冠心病组比较，冠心病并发重度牙周炎组SCD40L水平升高（P<0.05）；与冠心病组比较，冠心病并发重度牙周炎组余留牙数目少（P<0.05）；与冠心病组比较，冠心病并发重度牙周炎组PD水平较深（P<0.05）；与冠心病组比较，冠心病并发重度牙周炎组CAL及BOP增高（P<0.01）。SCD40L与PD存在明显正相关（P<0.01），SCD40L与BOP具有正相关性（P<0.05）。结论 SCD40L可作为预测冠心病并发重度牙周炎的炎性预测因子。
Abstract:
AIM To investigate the role of SCD40L in the occurrence, development and correlativity of coronary heart disease(CHD)in patients with severe periodontitis. METHODS 63 patients were divided into healthy controls (n=14), severe periodontitis group (n=16), coronary heart disease group (n=19) and coronary heart disease in patients with severe periodontitis(n=14). Venous blood was taken to measure the concentration of SCD40L in serum. between coronary heart disease group and coronary heart disease in patients with severe periodontitis group of periodontal parameters (Probing depth, clinical attachment loss, bleeding on probing, plaque index and the remaining teeth) was determined. Correlation analysis between SCD40L and CAL, PD, PLI and BOP was performed to observe the correlation between SCD40L and periodontal parameters. RESULTS Compared with the healthy control group, coronary heart disease group and severe periodontitis group SCD40L was singificantly higher than the healthy control group (P<0.01). Compared with the severe periodontitis group and coronary heart disease, increased SCD40L level in coronary heart disease patients with severe periodontitis group and the difference was statistically significant (P<0.05). Compared with the group of coronary heart disease, remaining teeth number in coronary heart disease and severe periodontitis group was statistically significant (P<0.05), compared with the group of coronary heart disease Probing depth level in coronary heart disease and severe periodontitis group was deeper (P<0.05), CAL and BOP have was increased statistical significance (P<0.01). SCD40L and BOP had existed a positive correlation (P<0.05). CONCLUSION SCD40L can be used as a predictive factor for predicting the severity of coronary artery disease in patients with severe periodontitis.

参考文献/References

[1]刘钰宇.冠心病与慢性牙周炎相关性的分析[J].现代口腔医学杂志,2016,30(3):169-172.

[2]Dibra A,Mehilli J,Braun S,et al.Association between C-reactive protein levels and subsequent cardiac events among patients with stable angina treated with coronary artery stenting[J].Am J Med,2003,114(9):715-722.

[3]Napole?o P,Cabral LB,Selas M,et al.Stratification of ST-elevation myocardial infarction patients based on soluble CD40L longitudinal changes[J].Transl Res,2016,176:95-104.

[4]Armitage GC,Wu Y,Wang HY,et al.Low Prevalence of a Periodontitis associated interleukin-1 composite genotype in individuals of Chinese heritage[J].J Periodontol,2000,712:164-171.

[5]Ong P,Carro A,Athanasiadis A,et al.Acetylcholine-induced coronary spasm in patients with unobstructed coronary arteries is associated with elevated concentrations of soluble CD40 ligand and high-sensitivity C-reactive protein[J].Coron Artery Dis,2015,26(2):126-132.

[6]Leite AC,Carneiro VM,Guimar?es Mdo C,et alEffects of periodontal therapy on C-reactive protein and HDL in serum of subjects with periodontitis[J].Rev Bras Cir Cardiovasc,2014,29(1):69-77.

[7]Hansen GM,Egeberg A,Holmstrup P,et al.Relation of Periodontitis to Risk of Cardiovascular and All-Cause Mortality(from a Danish Nationwide Cohort Study)[J].Am J Cardiol,2016,118(4):489-493.

[8]Ionel A,Lucaciu O,Bondor C,et al.Assessment of the relationship between periodontal disease and cardiovascular disorders:a questionnaire-based study[J].Clujul Med,2016,89(4):534-541.

备注/Memo

备注/Memo:
收稿日期：2017-02-17.通讯作者：孟晓雪，主治医师，硕士，主要从事冠心病诊断及介入治疗研究Email：mengxiaoxue1122@126.com
更新日期/Last Update: 1900-01-01