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|本期目录/Table of Contents|

单核-巨噬细胞与缺血性心脏病：心梗引起心梗？

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2018年第1期
页码:
95-098
栏目:
综述
出版日期:
2017-10-10

文章信息/Info

Title:
Monocytes and macrophages in ischemic heart disease: does myocardial infarction begets myocardial infarction?
作者:
周 敏1; 袁 卓2; 仲爱芹3; 张军平3
(天津中医药大学：1.研究生院，2.第一附属医院心身科，3.第一附属医院心血管科，天津 300193)
Author(s):
ZHOU Min1;  YUAN Zhuo2;  ZHONG Ai-qin3;  ZHANG Jun-ping3
(1.Graduate School, 2.Department of Psychosomatic Medicine, 3.Department of Cardiovascular Medicine, First Affiliated Hospital, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China)
关键词:
单核细胞; 巨噬细胞; 动脉粥样硬化; 心肌梗死
Keywords:
monocyte;  macrophage;  atherosclerosis;  myocardial infarction
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
急性冠脉综合征后发生死亡、再梗及卒中等后续不良事件风险增加是缺血性心脏病的研究热点。单核-巨噬细胞广泛参与动脉粥样硬化斑块形成、破裂及心肌缺血损伤、修复。心肌梗死(MI)后交感神经激活，骨髓和脾脏造血作用增强，导致循环中炎性单核细胞激增，改变斑块中巨噬细胞的表型及供应链，从而加速动脉粥样斑块的发展，可能导致再梗或再缺血的发生。本文将对MI如何通过单核-巨噬细胞途径加重动脉粥样硬化进行综述。
Abstract:
Monocytes and their descendant macrophages play an important role in the occurrence and development of atherosclerosis and in inflammation and reparation after myocardial infarction. Activation of the sympathetic nervous system after myocardial infarction results in mobilization of hematopoietic stem cells, causing an inflammatory monocyte boost, which alters the macrophage phenotype and supply chain and accelerates atherosclerosis. These results may be related to increased risk of recurrent ischemic coronary events following myocardial infarction. How myocardial infarction accelerates atherosclerosis through monocyte/macrophage is reviewed in this article.

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备注/Memo

备注/Memo:
收稿日期：2016-11-29.基金项目：国家自然科学基金项目资助(81403332)；天津市应用基础与前沿技术项目资助(13JCQNJC12600) 通讯作者：张军平,主任医师，主要从事中医学防治心血管病研究 Email:tjzhtcm@163.com 作者简介：周敏，硕士生 Email:861740527@qq.com
更新日期/Last Update: 1900-01-01