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|本期目录/Table of Contents|

冠状动脉粥样硬化性心脏病之“狭窄”“斑块”说拨误

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2018年第1期
页码:
107-112
栏目:
综述
出版日期:
2017-10-10

文章信息/Info

Title:
Re-recognization of “stenosis” and “plaque” in ischemic heart disease
作者:
周 欢1张军平2王 彬3
(1.天津市南开大学附属医院中医科,天津 300222;天津中医药大学第一附属医院:2.心血管科,3.内分泌科,天津 300193)
Author(s):
ZHOU Huan1 ZHANG Jun-ping2 WANG Bin3
(1.Traditional Chinese Medicine Department,Affiliated Hospital, Nankai University, Tianjin 300222, China; 2.Department of Cardiovascular Medicine, 3.Department of Endocrinology, First Teaching Hospital, Tianjin University of Traditional Chinese Medicine,
关键词:
缺血性心脏病狭窄斑块心血管事件
Keywords:
ischemic heart disease stenosis plaque cardiovascular events
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
缺血性心脏病是一种多因性复杂性疾病,涉及到血管、血液、心肌、精神心理等多个维度。既往的观点一直陷在将血管的解剖学狭窄与缺血缺氧以及临床心血管事件线性对应的一元论泥潭里,但真实世界的临床实践资料却不断冲击着传统的“狭窄”、“斑块”认识,所以,有必要重新审视管腔“狭窄”学说以及以“狭窄”为导向的治疗在缺血性心脏病中所处的地位,较好地回答和解释所谓的析“因”性治疗与实际临床结果相悖的原因。
Abstract:
Ischemic heart pathogenesis is a multi-factorial and complex disease, which involves vessels, blood, myocardium, and psychological aspects. Numerous previous reviews have focused on anatomic injury, anoxia, or cardiovascular events, but recent clinical data challenges these traditional factors. Therefore, this review takes a new look at “stenosis” and stenosis elimination treatment, preferably finding potential better solutions to the contradiction between factorial treatment and clinical outcome.

参考文献/References

[1]Ong P,Athanasiadis A,Borgulya G,et al.High prevalence of a pathological response to acetylcholine testing in patients with stable anginapectoris and unobstructed coronary arteries. The ACOVA Study(Abnormal COronary VAsomotionin patients with stable angina and unobstructed coronary arteries)[J].J Am Coll Cardiol,2012,59(7):655-662.

[2]Sara JD,Widmer RJ,Matsuzawa Y,et al.Prevalence of Coronary Microvascular Dysfunction Among Patients With Chest Pain and NonobstructiveCoronary Artery Disease[J].JACC Cardiovasc Interv,2015,(11):1445-1453.

[3]Melikian N,Vercauteren S,Fearon WF,et al.Quantitative assessment of coronary microvascular function in patients with and without epicardial atherosclerosis[J].EuroIntervention,2010,5(8):939-945.

[4] Berger JS,Elliott L,Gallup D,et al.Sex differences in mortality following acute coronary syndromes[J].JAMA,2009,302(8):874-882.

[5]Park GM,Lee SW,Cho YR,et al.Coronary computed tomographic angiographic findings in asymptomatic patients with type 2 diabetes mellitus[J].Am J Cardiol,2014,113(5):765-771.

[6]van den Hoogen IJ,de Graaf MA,Roos CJ,et al.Prognostic value of coronary computed tomography angiography in diabetic patients without chest pain syndrome[J].J Nucl Cardiol,2016,23(1):24-36.

[7]Young LH,Wackers FJ,Chyun DA,et al.Cardiac outcomes after screening for asymptomatic coronary artery disease in patients with type 2 diabetes:the DIAD study:a randomized controlled trial[J].JAMA,2009,301(15):1547-1555.

[8]Eskerud I,Gerdts E,Nordrehaug JE,et al.Global Coronary Artery Plaque Area is Associated with Myocardial Hypoperfusion in Women with Non-STElevation Myocardial Infarction[J].J Womens Health(Larchmt),2015,24(5):367-373.

[9]Pijls NH,Fearon WF,Tonino PA,et al.Fractional flow reserve versus angiography for guiding percutaneous coronary intervention in patients with multivessel coronary artery disease:2-year follow-up of the FAME(Fractional Flow Reserve Versus Angiography for Multivessel Evaluation)study[J].J Am Coll Cardiol,2010,56(3):177-184.

[10]De Bruyne B,Pijls NH,Kalesan B,et al.Fractional flow reserve-guided PCI versus medical therapy in stable coronary disease[J].N Engl J Med,2012,367(11):991-1001.

[11]Curzen N,Rana O,Nicholas Z,et al.Does routine pressure wire assessment influence management strategy at coronary angiography for diagnosis of chest pain?:The RIPCORD study[J].Circ Cardiovasc Interv,2014,7(2):248-255.

[12]Herrmann J,Kaski JC,Lerman A.Coronary microvascular dysfunction in the clinical setting:from mystery to reality[J].Eur Heart J,2012,33(22):2771-2782.

[13]Sen T.Coronary Slow Flow Phenomenon Leads to ST Elevation Myocardial Infarction[J].Korean Circ J,2013,43(3):196-198.

[14]Xu Y,Meng HL,Su YM,et al.Serum YKL-40 is increased in patients with slow coronary flow[J].Coron Artery Dis,2015,26(2):121-125.

[15]Dogan M,Akyel A,Cimen T,et al.Relationship between neutrophil to lymphocyte ratio and slow coronary flow[J].Clin Appl Thromb Hemost,2013,21(3):251-254.

[16]Akboga MK,Canpolat U,Balci KG,et al.Increased Platelet to Lymphocyte Ratio is Related to Slow Coronary Flow[J].Angiology,2016,67(1):21-26.

[17]Badimon L,Vilahur G.Thrombosis formation on atherosclerotic lesions and plaque rupture[J].J Intern Med,2014,276(6):618-632.

[18]Rana A,Goyal N,Ahlawat A,et al.Mechanisms involved in attenuated cardio-protective role of ischemic preconditioning in metabolic disorders[J].Perfusion,2015,30(2):94-105.

[19]Maslov LN,Naryzhnaya NV,Pei JM,et al.Problem of end-effector of ischemic postconditioning of the heart[J].Ross Fiziol Zh Im I M Sechenova,2015,101(6):647-669.

[20]Thomas RL,Gustafsson AB.Mitochondrial autophagy--an essential quality control mechanism for myocardial homeostasis[J].Circ J,2013,77(10):2449-2454.

[21]Wojciechowska M,Zarebiński M,Pawluczuk P,et al.Decreased effectiveness of ischemic heart preconditioning in the state of chronic inflammation[J].Med Hypotheses,2015,85(5):675-679.

[22]Chytilová A,Borchert GH,Mandíková-Alánová P,et al.Tumour necrosis factor-α contributes to improved cardiac ischaemic tolerance in rats adapted to chroniccontinuous hypoxia[J].Acta Physiol(Oxf),2015,214(1):97-108.

[23]Arbab-Zadeh A,Nakano M,Virmani R,et al.Acute coronary events[J].Circulation,2012,125(9):1147-1156.

[24]Dong L,Mintz GS,Witzenbichler B,et al.Comparison of plaque characteristics in narrowings with ST-elevation myocardial infarction(STEMI),non-STEMI/unstable angina pectoris and stable coronary artery disease(from the ADAPT-DES IVUS Substudy)[J].Am J Cardiol,2015,115(7):860-866.

[25]Kubo T,Maehara A,Mintz GS,et al.The dynamic nature of coronary artery lesion morphology assessed by serial virtual histology intravascular ultrasound tissue characterization[J].J Am Coll Cardiol,2010,55(15):1590-1597.

[26]Di Vito L,Prati F,Arbustini E,et al.A“stable”coronary plaque rupture documented by repeated OCT studies[J].JACC Cardiovasc Imaging,2013,6(7):835-836.

[27]Yonetsu T,Kakuta T,Lee T,et al.In vivo critical fibrous cap thickness for rupture-prone coronary plaques assessed by optical coherence tomography[J].Eur Heart J,2011,32(10):1251-1259.

[28]Stone GW,Maehara A,Lansky AJ,et al.A prospective natural-history study of coronary atherosclerosis[J].N Engl J Med,2011,364(3):226-235.

[29]Stergiopoulos K,Boden WE,Hartigan P,et al.Percutaneous coronary intervention outcomes in patients with stable obstructive coronary artery disease andmyocardial ischemia: a collaborative meta-analysis of contemporary randomized clinical trials[J].JAMA Intern Med,2014,174(2):232-240.

[30]Zimmermann FM,Ferrara A,Johnson NP,et al.Deferral vs. performance of percutaneous coronary intervention of functionally non-significant coronary stenosis:15-year follow-up of the DEFER trial[J].Eur Heart J,2015,36(45):3182-3188.

[31]Lautam?ki A,Airaksinen KE,Kiviniemi T,et al.Prognosis and disease progression in patients under 50 years old undergoing PCI:the CRAS(Coronary aRterydiseAse in younG adultS)study[J].Atherosclerosis,2014,235(2):483-487.

[32]Fach A,Bünger S,Zabrocki R,et al.Comparison of Outcomes of Patients With ST-Segment Elevation Myocardial Infarction Treated by Primary Percutaneous Coronary Intervention Analyzed by Age Groups(<75, 75 to 85, and >85 Years);(Results from the Bremen STEMI Registry)[J].Am J Cardiol,2015,116(12):1802-1809.

[33]Shaw LJ,Berman DS,Maron DJ,et al. Optimal medical therapy with or without percutaneous coronary intervention to reduce ischemic burden: resultsfrom the Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation (COURAGE) trial nuclearsubstudy[J].Circulation,2008,117(10):1283-1291.

[34]Fihn SD,Gardin JM,Abrams J,et al.2012 ACCF/AHA/ACP/AATS/PCNA/SCAI/STS guideline for the diagnosis and management ofpatients with stable ischemic heart disease: executive summary:a report of the American College of Cardiology Foundation/American Heart Association task force on practiceguidelines, and the American College of Physicians,American Association for ThoracicSurgery,Preventive Cardiovascular Nurses Association,Society for CardiovascularAngiography and Interventions,and Society of Thoracic Surgeons[J].Circulation,2012,126(25):3097-3137.

备注/Memo

备注/Memo:
收稿日期:2016-08-30.基金项目:国家自然科学基金项目资助(81473634) 通讯作者:张军平,主任医师,主要从事中医药防治心血管病研究 Email:zjtcm@163.com 作者简介:周欢,住院医师,博士 Email:chunyuchuting8@126.com
更新日期/Last Update: 1900-01-01