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|本期目录/Table of Contents|

国产比伐卢定在老年急性冠脉综合征患者介入术中治疗效果

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2018年第2期
页码:
159-161,169
栏目:
临床研究
出版日期:
2018-02-15

文章信息/Info

Title:
The therapeutic effect of bivalirudin during primary percutaneous coronary intervention in elderly patients with acute coronary syndrome
作者:
童健文蔡国才
(成都医学院第一附属医院心血管内科,四川 成都 610500)
Author(s):
TONG Jian-wen CAI Guo-cai
(Department of Cardiology, First Affiliated Hospital, Chengdu Medical College, Chengdu 610500, Sichuan, China)
关键词:
比伐卢定肝素老年急性冠脉综合征经皮冠状动脉介入治疗
Keywords:
bivalirudin heparin aged acute coronary syndrome percutaneous coronary intervention
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 研究老年(年龄>65岁)急性冠脉综合征(ACS)患者在经皮冠脉介入(PCI)治疗术中使用国产比伐卢定的安全和有效性。方法 本研究通过回顾性分析我院35例PCI术中应用比伐卢定的老年ACS患者的临床资料,按1∶1匹配选取同期35例PCI治疗过程中常规应用普通肝素的老年ACS患者作为对照组,分析术后30 d内的主要不良心脑血管事件(major adverse cardiac and cerebrovascular events,MACCE)及出血并发症的发生情况。结果 两组临床资料对比,差异无统计学意义。术后30 d内MACCE发生率分别为4例(11%)和5例(14%),差异无统计学意义;出血并发症发生率分别为1例(3%)和6例(17%),比伐卢定组优于普通肝素组(P<0.05)。结论 老年ACS患者PCI术中使用比伐卢定与普通肝素相比,可减少术后30d内的出血事件发生率,且不增加MACCE的风险。
Abstract:
AIM AIMTo evaluate the efficiency and safety of bivalirudin during percutaneous coronary intervention (PCI) in elderly patients (Age>65) with acute coronary syndrome (ACS). METHODS Medical records were analyzed in 35 patients given bivalirudin during PCI. The same type of records were screened in which unfractionated heparin (UFH) was used during PCI at a ratio of 1∶1 for a control group of 35 patients.The main endpoint events included major adverse cardiac and cerebrovascular events (MACCE) and severe bleeding complications at 30 days. RESULTS There were no significant differences between the two groups.The incidences of MACCE (11% vs. 14%), which was 4 for bivalirudin and 5 for heparin at 30 days, demonstrated no statistical significance.The incidences of bleeding (3% vs. 17%, P<0.05), which was 1 for bivalirudin and 6 for heparin, showed that the bivalirudin group is superior to the heparin group. CONCLUSION The use of bivalirudin resulted in a decrease in bleeding events without significant difference in MACCE compared with heparin alone at 30 days.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期:2017-05-18.通讯作者:蔡国才,副主任医师,主要从事心血管病介入治疗研究 Email:56402562@qq.com 作者简介:童健文,住院医师,硕士生 Email:313140364@qq.com
更新日期/Last Update: 1900-01-01