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|本期目录/Table of Contents|

益气活血温阳法治疗慢性心力衰竭疗效及对NT-proBNP、hs-CRP的影响

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2018年第2期
页码:
196-199
栏目:
临床研究
出版日期:
2018-02-15

文章信息/Info

Title:
Yiqi Huoxue Wenyang method for treatment of chronic heart failure and its influence on NT-proBNP and hs-CRP
作者:
郭 悦
（辽宁中医药大学附属医院心内科，辽宁 沈阳 110032）
Author(s):
GUO Yue
(Department of Cardiology, Affiliated Hospital, Liaoning University of Traditional Chinese Medicine, Shenyang 110032, Liaoning, China)
关键词:
益气活血温阳; 心力衰竭; 慢性; N末端脑钠尿肽前体; 超敏C反应蛋白
Keywords:
Qi Wen Yang and promoting blood circulation;  chronic heart failure;  NT-pro BNP;  hs-CRP
分类号:
R256.22
DOI:
-
文献标识码:
A
摘要:
目的 观察用益气温阳活血法治疗慢性心力衰竭(CHF)的临床疗效及对N末端脑钠尿肽前体（NT-proBNP）、超敏C反应蛋白（hs-CRP）的影响。方法 选择72例我科室收治的CHF患者，按随机数字法分为常规组（35例）和试药组（37例），两组患者均根据病情给予西医常规治疗，试药组再加用自拟中药益气温阳活血复方。结果 试药组总有效率（89%）明显高于常规组（77%）（P<0.05）；治疗前两组左室舒张末期直径（LVEDD）、左室射血分数（LVEF）、舒张早期E峰流速与舒张晚期A峰流速的比值（E/A）、NT-proBNP、hs-CRP等差异均无统计学意义。治疗后两组均有改善，试药组显著优于常规组（P<0.05）。结论 在西医常规治疗的基础上加用益气温阳活血法治疗CHF效果显著优于单纯西医（常规）治疗。
Abstract:
AIM To observe the clinical effect of the method of Yiqi Huoxue Wenyang (supplementing Qi and warming yang and promoting blood circulation) in the treatment of chronic heart failure and its effect on hs-CRP and NT-proBNP. METHODS Seventy-two patients with chronic heart failure in our hospital were divided into two groups using the method of random data points, e.g., routine group (35 cases) and treatment group (37 cases). Patients in both groups were given conventional Western medicine treatment according to their conditions, while the patients in the observation group were additionally given Yiqi Wenyang Huoxue Compound, a self-made traditional Chinese medicine. RESULTS Total efficiency in the observational group was significantly higher than that in the routine group (89% vs. 77%) and the difference was significant (P<0.05). Before treatment, no significant differences were found in LVEDD, LVEF and E/a value between the two groups. After treatment, the indexes were improved in both groups, but the improvement in the observational group was much better than that in the routine group (P<0.05). Before treatment, no significant difference was found in the values of hs-CRP and NT-pro BNP between the two groups. After treatment, both groups were both improved, but the improvement in the observational group was much better than that in the routine group (P<0.05). CONCLUSION The therapeutic effect of conventional treatment of Western medicine plus the method of Invigorating Qi and warming yang and promoting blood circulation is superior to Western medicine alone in the treatment of patients with chronic heart failure.

参考文献/References

[1]Kitzman DW,Brubaker P,Morgan T,et al.Effect of Caloric Restriction or Aerobic Exercise Training on Peak Oxygen Consumption and Quality of Life in Obese Older Patients With Heart Failure With Preserved Ejection Fraction:A Randomized Clinical Trial[J].JAMA,2016,315(1):36-46.

[2]Borovkova NJ,Kuznecova TE,Borovkov NN,et al.Therapy of Arterial Hypertension in Patients With Chronic Heart Failure and Signs of Chronic Kidney Disease With Fixed Perindopril/Amlodipine Combination[J].Kardiologiia,2015,55(6):22-26.

[3]Grizywa-Celinska A,Dyczko M,Rekas-Wojcik A,et al.Ventilatory disorders in patients with chronic heart failure[J].Pol Merkur Lekarski,2015,39(232):248-250.

[4]孙龙飞,安冬青,郭龙龙.心力衰竭的中医药治疗优势与特色[J].中国中医急症,2016,25(3):452-456.

[5]郑筱萸.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:77-85.

[6]Martine Z,Rumayor A,Richards AM,et al.Biology of the natriuretic peptides[J].Am J Cardiol,2008,101(3A):3-8.

[7]Daniels B,Maisel A.Natriuertic peptides[J].J Am Coll Cardiol,2007,50(25):2357-2368.

[8]Cynthia MB,Pasqualina S,Robert M,et al.Physioligical, pathological,pharmacolo-gical, biocheemical and hematological factors affecting BNP and NT-pro BNP[J].Clin Biochem,2008,41(10):231-239.

[9]方玉才,邢小中,蒋洪平,等.脑梗死患者治疗前后血浆同型半胱氨酸的变化[J].检验医学,2008,23(2):190-192.

[10]姜淑琴.心力衰竭的中医辨治[J].现代中西医结合杂志,2004,13(13):1799.

[11]尹克春,吴焕林,邓铁涛.治疗心力衰竭经验介绍[J].江苏中医药,2002,23(7):9-10.

[12]袁国强,李彦霞,魏 聪.从脉络学说论治慢性心力衰竭[J].中国中医基础医学杂志,2012,18(8):820-822.

[13]华新宇.慢性心力衰竭中医病机的三焦观[J].光明中医,2010,25(11):1963-1964.

[14]程 丹,程晓昱.益气温阳活血利水法治疗慢性心力衰竭的研究进展[J].中医药信息,2016,1(33):111-113.

[15]杨志霞,李振彬,林 谦,等.黄芪多糖联合丹参酮阻断慢性心衰大鼠NF-κB激活MIF、TNF-α及IL-6表达的研究[J].中华中医药杂志,2012,12(27):3221-3225.

[16]李 岩,武 乾,林 谦.补气药党参黄芪对慢性心衰大鼠血流动力学的影响[J].中国中医基础医学杂志,2010,16(7):597-598.

[17]姬艳苏,王 怡.黄芪皂苷治疗心力衰竭机制研究现状[J].江苏中医药,2009,41(4):78-80.

[18]赵益业,林晓忠,邹 旭,等.心力衰竭防治的中西医契合点探讨[J].辽宁中医杂志,2007,34(10):1390-1392.

[19]贺运河，陈镜合,陈世伟,等.参附合香丹注射液治疗肺心病急性发作期合并心力衰竭的临床研究[J].中国中医急症,2004,13(1):21-22.

[20]曾垂义,王振涛.温 阳、益气、活血中药对心力衰竭大鼠神经内分泌的远期疗效[J].中国实验方剂学杂志,2010,16(16):158-159.

备注/Memo

备注/Memo:
收稿日期：2017-02-23.作者简介：郭悦，主治医师，硕士 Email：csguoyue@163.com
更新日期/Last Update: 1900-01-01