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|本期目录/Table of Contents|

慢性盐负荷对血压盐敏感者血浆内皮生长因子C的影响

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2018年第3期
页码:
293-295,308
栏目:
临床研究
出版日期:
2018-03-25

文章信息/Info

Title:
Effects of chronic salt loading on plasma vascular endothelial growth factor C in salt-sensitive adults
作者:
刘富强1; 2; 朱占芳3; 张荣怀1; 4; 刘仲伟1; 褚 超2; 汪 洋2; 王军奎1; 官功昌1; 牟建军2
（1.陕西省人民医院、西安交通大学第三附属医院心内科，陕西 西安 710068；2.西安交通大学第一附属医院心内科，陕西 西安 710061；3.西安交通大学医院，陕西 西安 710068；4.第四军医大学西京医院老年病科，陕西 西安 710032）
Author(s):
LIU Fu-qiang1; 2;  ZHU Zhan-fang3;  ZHANG Rong-huai1; 4;  LIU Zhong-wei1;  CHU Chao2;  WANG Yang2;  WANG Jun-kui1;  GUAN Gong-chang1;  MU Jian-jun2
(Department of Cardiology, Beijing Friendship Hospital Affiliated to Capital Medical University, Beijing 100050, China)
关键词:
盐敏感性; 淋巴系统; 内皮生长因子C; 饮食干预
Keywords:
salt-sensitive;  lymphatic system;  vascular endothelial growth factor C;  diet intervention
分类号:
R544.1
DOI:
-
文献标识码:
A
摘要:
目的 本研究通过对正常血压受试者进行饮食干预试验，观察高盐对盐敏感者血浆内皮生长因子C(VEGF-C)的影响，探索淋巴系统在盐敏感性形成过程中的作用。方法对27例血压正常受试者进行7 d低盐、7 d高盐饮食干预，采用国际慢性盐负荷试验鉴别盐敏感者，筛选出盐敏感者9例，盐不敏感者18例，采用ELISA方法测定血浆VEGF-C的含量。结果两组受试者低盐期血浆VEGF-C水平比较无统计学差异〔(1921±238) mg/L vs.(1804±206) mg/L，P=0.59〕，而高盐干预后两组血浆VEGF-C水平均较低盐期明显增加〔盐敏感组(3642±406) mg/L，盐不敏感组(2249.8±214.6) μg/ml〕，并且高盐干预后盐敏感组VEGF-C水平较盐不敏感组显著升高（P<0.01）；相关分析表明，血浆VEGF-C水平与血压之间未发现具有统计学意义的相关性（r=0.412，P=0.29）。结论高盐饮食后盐敏感者体内VEGF-C显著升高，而VEGF-C可能成为盐敏感性识别的重要生化标记物之一。
Abstract:
AIM To investigate the effects of chronic salt loading on plasma vascular endothelial growth factor C (VEGF-C) in salt-sensitive normotensive adults and to explore the role of the lymphatic system in the development of salt-sensitive hypertension in humans. METHODSTwenty-seven subjects from a rural community were enrolled in this study. The baseline BP of volunteers was monitored, followed by a low-salt diet for 7 days and a high-salt diet for 7 days. Nine subjects were diagnosed with salt sensitivity, and the other eighteen with salt resistance. The concentration of plasma VEGF-C was measured by an immunoenzyme method (ELISA). RESULTSHigh salt intake significantly increased the plasma VEGF-C level. It was higher in the salt-sensitive subjects (3642±406) mg/L, when compared with the salt-resistant subjects (2250±215) mg/L. The comparison of VEGF-C levels between the 2 groups had significant statistical difference (P<0.01). CONCLUSIONThe VEGF-C level increases significantly in salt-sensitive subjects after high salt intake. VEGF-C could be used as a biomarker of salt sensitivity.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2017-06-05.作者简介：刘富强，副主任医师，博士 Email：liufuqiang0909@163.com
更新日期/Last Update: 1900-01-01