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|本期目录/Table of Contents|

心房血清TNF-α及IL-6水平与非结构性心脏病房颤的相关性

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2018年第3期
页码:
326-328,337
栏目:
临床研究
出版日期:
2018-03-25

文章信息/Info

Title:
The correlation between atrial serum TNF-α and IL-6 Levels and atrial fibrillation
作者:
曹 威1; 李茜楠1; 崔金金1; 王 帆1; 于 波1; 栾 颖1; 刘娴2 ; 田 野3; 李述峰1
(哈尔滨医科大学:1.附属第二医院心内科，黑龙江 哈尔滨 150001，2.附属第四医院心内科，黑龙江 哈尔滨 150021，3.附属第一医院心内科，黑龙江 哈尔滨 150001)
Author(s):
CAO Wei1;  LI Qian-nan1;  CUI Jin-jin1;  WANG Fan1;  YU Bo1;  LUAN Ying1;  LIU Xian2;  TIAN Ye3;  LI Shu-feng1
(1.Department of Cardiology, Second Affiliated Hospital, Harbin 150001, Heilongjiang, China, 2.Department of Cardiology, Fourth Affiliated Hospital, Harbin 150021, Heilongjiang, China, 3.Department of Cardiology, First Affiliated Hospital, Harbin Medical University, Harbin 150001, Heilongjiang, China)
关键词:
心房颤动; 肿瘤坏死因子-α; 白介素-6
Keywords:
atrial fibrillation;  tumor necrosis factor-α;  interleukin-6
分类号:
R514.7
DOI:
-
文献标识码:
A
摘要:
目的 通过对心房颤动(房颤)患者左心房或右心房中血清肿瘤坏死因子(TNF)-α与白细胞介素(IL)-6的水平检测，探讨两种炎症因子与无结构性心脏病的患者房颤发生的关系。方法 59例首选射频消融术治疗方案的心律失常患者，59例患者心脏皆无结构性病变，其中包括房颤患者42例（阵发性房颤24例、持续性房颤18例）、预激综合征或阵发性室上性心动过速患者共17例，分别纳入房颤组及非房颤组。术前分别采集两组患者左房和右房中血液，并通过ELISA方法对血清样本的TNF-α、IL-6水平进行检测，应用心脏超声测量左心房内径（LAD）、左心室舒张末期内径（LVEDD）及左室射血分数（LVEF）等。结果 在两组比较中，房颤组LAD（36±7）mm显著高于非房颤组（31±4）mm（P<0.01）；TNF-α水平及IL-6L水平在房颤组的左、右心房的血清中含量均显著高于非房颤组，依次为P<0.01及P<0.05。在对房颤组中持续性房颤与阵发性房颤的组内亚组比较中：持续性房颤血清IL-6（17±9）pg/ml显著高于阵发性房颤组（12±5）pg/ml（P<0.05），而持续性房颤及阵发性房颤的血清TNF-α水平均无显著差异。结论 心房血清TNF-α、IL-6水平与无结构性心脏病的房颤有相关性，持续性房颤患者心房血清IL-6 水平较阵发性房颤患者有升高趋势，可以作为房颤持续的预测因子。
Abstract:
AIM To detect the relationship between left or right atrial serum tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) levels in atrial fibrillation patients with non- structural heart disease and to explore inflammatory changes in different types of atrial fibrillation and possible clinical implications. METHODS 59 patients were selected intending to have radiofrequency ablation of arrhythmias, who had no structural heart disease. 42 patients had atrial fibrillation, 17 patients had paroxysmal supraventricular tachycardia or pre-bowel syndrome. Samples were collected from left and right atrial blood before surgery and tested for serum TNF-α, IL-6 levels by ELISA, echocardiography to measure left atrial diameter. Statistical methods compared differences of the two groups. RESULTS In comparison with the control group of atrial fibrillation, the atrial fibrillation group significantly increased left atrial diameter (36±7) mm compared with the control group (31±4) mm (P <0.01); AF group left and right atrium TNF-α levels were significantly higher (P<0.01); AF group left and right atrium serum IL-6L was significantly higher (P<0.05); persistent AF group, the serum IL-6 (17±9) pg/ml was higher than the paroxysmal AF group (12±5) pg/ml (P<0.05). The serum TNF-α levels and persistent atrial fibrillation and paroxysmal atrial fibrillation had no significant differences. CONCLUSION The serum TNF-α, IL-6 levels have relationsips to development of atrial fibrillation with non-structural heart disease and there was an increasing trend of serum IL-6 levels in patients with persistent atrial fibrillation when compared with the paroxysmal patients, and IL-6 could potentially be a factor in predicting sustained atrial fibrillation.

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备注/Memo

备注/Memo:
收稿日期：2017-04-25.作者简介：曹威，主治医师，博士 Email：caowei3442@126.com
更新日期/Last Update: 1900-01-01