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|本期目录/Table of Contents|

外泌体来源微小RNA在心血管疾病中作用研究进展

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2018年第4期
页码:
469-472
栏目:
综述
出版日期:
2018-04-25

文章信息/Info

Title:
Research progress of exosome-derived microRNA in cardiovascular diseases
作者:
潘益凯; 孙喜庆
(第四军医大学航空航天医学系航空航天生物动力学教研室、航空航天医学教育部重点实验室，陕西 西安 710032)
Author(s):
PAN Yi-kai;  SUN Xi-qing
(Department of Aerospace Biodynamics & MOE Key Laboratory of Aerospace Medicine, School of Aerospace Medicine, Fourth Military Medical University, Xi’an 710032, Shaanxi, China)
关键词:
外泌体; 微小RNA; 心血管疾病
Keywords:
exosomes;  microRNA;  cardiovascular diseases
分类号:
R54
DOI:
-
文献标识码:
A
摘要:
在不同的病理生理状态下，细胞可分泌包含有特定内含物的外泌体至细胞外环境中。其中，来源于外泌体的微小RNA(miRNA)能够参与细胞间的物质传递和信号转导。近年来，人们逐渐认识到外泌体及其相关的miRNA在心血管疾病发病过程中的重要作用。本文介绍了外泌体的基本特征及外泌体来源的miRNA的生物学特性，讨论了外泌体来源的miRNA在不同心血管疾病中的表达情况。
Abstract:
Cells secrete exosomes, which carry and transfer specific cargos into extracellular environment in both physiological and pathological conditions. Among these components, microRNA derived from exosomes can influence the function of cell-cell substances transmission and signal transduction. Recent studies have shown that exosomes and exosome-derived microRNA play important roles in pathogenesis of cardiovascular diseases. This review focuses on fundamental features of exosomes, biological characteristics and expressions of exosome-derived microRNA in different cardiovascular diseases.

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备注/Memo

备注/Memo:
收稿日期：2017-03-22基金项目：国家自然科学基金项目资助(81471817,81372130) 通讯作者：孙喜庆，教授，主要从事重力生物效应与医学防护研究 Email:sunxiqing@fmmu.edu.cn 作者简介：潘益凯，硕士生 Email:panyk0820@163.com
更新日期/Last Update: 1900-01-01