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|本期目录/Table of Contents|

动脉粥样硬化动物模型及其进展

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2018年第4期
页码:
490-493
栏目:
综述
出版日期:
2018-04-25

文章信息/Info

Title:
Advances in animal models of atherosclerosis
作者:
王 迪; 王 毅
(上海交通大学附属第一人民医院心内科，上海 200080)
Author(s):
WANG-Di;  WANG-Yi
(Department of Cardiology, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200080, China)
关键词:
动脉粥样硬化; 发病机制; 动物模型
Keywords:
atherosclerosis;  pathogenesis;  animal models
分类号:
R543.5
DOI:
-
文献标识码:
A
摘要:
动脉粥样硬化(AS)作为一种慢性炎症性疾病，已成为冠心病的主要病理生理学基础。目前，为进一步探讨其发病机制、病理变化以及制定防治策略，多种方法已广泛应用于AS模型的建立。本文以AS发病机制为线索，总结AS模型建立的方法及其优缺点，旨在寻找一种理想的动物模型，为AS的研究提供新的思路。
Abstract:
Atherosclerosis is a chronic inflammatory disorder, which has been the major pathophysiological basis of coronary heart disease. Different methods have been widely used to establish animal models of atherosclerosis in order to explore its pathogenesis, pathological changes, and develop prevention and treatment strategies. This manuscript summarizes establishment of animal models as well as their advantages and limitations in terms of mechanism of atherosclerosis, focusing on discovering one ideal animal model to provide new insights in the study of atherosclerosis.

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备注/Memo

备注/Memo:
收稿日期：2017-05-25.基金项目：国家自然科学基金项目资助（81470471） 通讯作者：王毅，主任医师，主要从事冠心病的基础与临床研究 Email：wangyipublic@hotmail.com 作者简介：王迪，硕士生 Email：15800601386@163.com
更新日期/Last Update: 1900-01-01