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|本期目录/Table of Contents|

尼可地尔在冠脉痉挛患者中的疗效和安全性

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2018年第5期
页码:
542-545
栏目:
临床研究
出版日期:
2018-06-25

文章信息/Info

Title:
Efficacy and safety of nicorandil in the treatment of patients with coronary artery spasm
作者:
王汝涛刘 毅廉 坤夏陈海贺 媛陶 凌
(空军军医大学第一附属医院心血管内科,陕西 西安 710032)
Author(s):
WANG Ru-tao LIU Yi LIAN Kun XIA Chen-hai HE Yuan TAO Ling
(Cardiovascular Department, First Affiliated Hospital, Air Force Military Medical University, Xi’an 710032, Shaanxi, China)
关键词:
尼可地尔冠脉痉挛疗效性安全性
Keywords:
nicorandil coronary artery spasm efficacy safety
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 探讨尼可地尔在治疗冠脉痉挛患者中的疗效及安全性。方法 通过冠脉造影筛选出符合冠脉痉挛的患者50例,随机分为对照组和试药组,对照组给予抗血小板、调脂等常规治疗,试药组在常规治疗的基础上加用尼可地尔5 mg(3次/d),观察两组临床疗效以及治疗前后内皮功能变化[NO含量与内皮素(ET)-1水平]及药物安全性。结果 试药组的治疗效果明显优于对照组(P<0.05),与治疗前相比,对照组治疗后NO含量增高(P<0.05),ET-1含量减低(P<0.05);尼可地尔组治疗3个月后,NO含量显著增加(P<0.01),ET-1含量显著减低(P<0.01)。治疗3个月后,与对照组相比,试药组NO含量显著增高(P<0.01),试药组ET-1含量显著减低(P<0.01),试药组仅发生1例轻微头痛,可耐受。结论 尼可地尔在治疗冠脉痉挛患者中具有良好的疗效和安全性。
Abstract:
AIM To investigate the efficacy and safety of nicorandil in the treatment of patients with coronary artery spasm. METHODS 50 patients with coronary artery spasm were randomly divided into a control group and a treatment group. The control group was given routine therapy, including antiplatelet and lipid therapy and the treatment group had routine therapy combined with nicorandil 5 mg, 3/d. Clinical therapy effects of the two groups and endothelial function were determined (the content of NO and endothelin-1) before and after treatment and drug safety was observed. RESULTS Compared with the control group, the clinical effects were clearly superior in the treatment group (P<0.05). After treatment, the NO content was increased (P<0.05), and the content of ET-1 was decreased (P<0.05) in the control group; After 3 months of treatment with nicorandil, the content of NO was increased significantly (P<0.01) and the ET-1 content was significantly decreased (P<0.01). Compared with the control group, treatment with nicorandil for 3 months increased the NO content (P<0.01), and decreased the ET-1 content significantly (P<0.01). The treatment group had only 1 adverse effecxt of mild headache which was tolerated by the patient. CONCLUSION Nicorandil has good efficacy and safety in the treatment of patients with coronary artery spasm.

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备注/Memo

备注/Memo:
收稿日期:2018-01-26.通讯作者:贺媛,主治医师,博士,主要从事冠心病的基础研究 Email:heyuan820927@163.com 作者简介:王汝涛,主治医师,硕士 Email:274535870@qq.com
更新日期/Last Update: 1900-01-01