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《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:

2018年第5期

页码:

575-579,593

栏目:

综述

出版日期:

2018-06-25

文章信息/Info

Title:

Research progress in relationship between telomere length and risk factors of cardiovascular disease

作者:

吕 涛; 郭文怡

（第四军医大学西京医院心血管内科，陕西 西安 710032）

Author(s):

L? Tao;  GUO Wen-yi

(Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, Shaanxi, China)

关键词:

冠状动脉疾病; 端粒; 端粒长度; 传统危险因素

Keywords:

coronary heart disease;  telomere;  telomere length;  traditional risk factors

分类号:

R541.4

DOI:

-

文献标识码:

A

摘要:

端粒是位于染色体末端的DNA重复序列,其功能是阻止染色体末端不被断裂和降解，维持染色体结构稳定和遗传稳定性，且随着细胞分裂而不断缩短，所以端粒长度可以作为生物衰老过程中的一个重要标记物。与2型糖尿病、阿尔茨海默病和骨质疏松等疾病一样，冠心病（CHD）也是一种年龄相关性疾病。端粒长度和CHD与机体衰老、退化均有着密切联系，且已有相关研究证明，白细胞端粒长度与CHD患病风险之间可能存在相关性，提示端粒可能参与了CHD的发生、发展，但其因果关系尚不明确。因此我们猜测端粒是否通过影响CHD的传统危险因素，进而促进CHD的发生、发展。本文就白细胞端粒长度与CHD传统危险因素关系研究进展作一综述。

Abstract:

Telomere, a DNA repeat sequence at the ends of chromosomes, 4 to 15 kbp, prevents the ends of chromosomes from being broken and dissolved and maintains structural and genetic stability of chromosomes. Owing to shortening after every replication, it could potentically be an important biomarker in the process of biological aging. Consistent with T2DM, Alzheimer disease and osteoporosis, coronary heart disease is also an aging-related disease. Telomere length and coronary heart disease are closely related to organism aging and degeneration and relevant studies have demonstrated that leukocyte telomere length may be associated with coronary heart disease. This suggests that telomeres may be involved in the occurrence and development of coronary heart disease but the causality remains uncertain. Therefore, we consider telomere affects when compared with traditional risk factors of coronary heart disease. In summary, this article reviews research progress in the relationship between leukocyte telomere length and traditional risk factors of coronary heart disease.

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备注/Memo

备注/Memo:

收稿日期：2017-03-17.通讯作者：郭文怡，主任医师，主要从事冠心病临床研究 Email：guowenyi@ tom.com 作者简介：吕涛，住院医师,硕士 Email：15229882294@163.com

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更新日期/Last Update: 1900-01-01