我们的网站为什么显示成这样？

可能因为您的浏览器不支持样式，您可以更新您的浏览器到最新版本，以获取对此功能的支持，访问下面的网站，获取关于浏览器的信息：

|本期目录/Table of Contents|

牛磺酸对心功能不全心肌细胞保护作用的初步研究(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
1995年第3期
页码:
145-148
栏目:
论著
出版日期:
1995-05-01

文章信息/Info

Title:
Investigation on taurine protection of cardiac muscle cells in heart failure
作者:
徐洪涛1 石湘芸1 赵云涛1 陈玉广1 刘志敏1 张 晶1 费宇行1 宫长宁2 唐朝枢2
1海军总医院心内科 北京 100037 2北京医科大学心肺内分泌研究室
Author(s):
Xu Hongtao; Shi Xiangyun; Zhao Yuntao; et al
Department of Cardiology，Naval General Hospital，Beijing 100037
关键词:
心力衰竭; 心功能; 牛磺酸; 大鼠; 心肌再灌注损伤; 超氧化物歧化酶; 丙二醛
Keywords:
heart failure; heart function; taurine; rats; myocardial reperfusion injury; superoxide dismutase; malondialdehyde
分类号:
-
DOI:
-
文献标识码:
-
摘要:
作者在31例心功能不全病人及离体大鼠心脏缺血-再灌注模型上给予牛磺酸治疗后，观察铜、锌超氧化物歧化酶(CuZnSOD)、脂质过氧化终产物丙二醛(MDA)水平的改变及其与心功能变化的关系。结果发现心功能不全患者的超氧化物歧化酶(SOD)、MDA随心衰严重程度而增加，应用牛磺酸治疗2周后，血中SOD、MDA水平显著降低，且随疗程延长效果更显著。牛磺酸与血管扩张剂、利尿剂及强心剂联合应用，较单用牛磺酸治疗效果更佳。大鼠心脏缺血、再灌注损伤后，心功能降低，心肌组织脂质过氧化终产物MDA的含量明显增加，补充牛磺酸后，心功能明显改善，MDA显著降低，证实牛磺酸是正常机体的内源性抗氧化剂，具有清除自由基的作用，因此有可能作为临床防治心衰的辅助药物。
Abstract:
In this study，we investigated the relations between the changes of CuZnSOD，MDA and the heart function after taurine treatment on 31 patients with heart failure and rat heart ischemia reperfusion models.The results showed that the level of SOD，MDA of the heart failure patients increased obviously with severity of the heart decay．However，after two weekt’s taurine treatment,the level of SOD，MDA showed a distinct decrease，and the longer the taurine treatment，the more obyious the effect. Especially when taurine combined with blood vessel expander and diuretic Was used.the treatment effect was much better． After taurine Was infused into heart degration rats with ischemia-reperfusion and high MDA and LPO level，the heart was improved and MDA，LPO level decreased sharply．These results illustrate that taurine is an endogenous anti-oxidant to a normal organism，it can be used as a kind of free-radical scavenger.So it is quite possible that taurine can be used as a clinical adjuvant to prevent and treat heart failure．

参考文献/References

［1］刘庆德,唐朝枢,苏静怡,等.牛磺酸的生理学效应.国外医学生理、病理生理科学与临床分册1991；11 (1)：3.

［2］佟利家,张灵芝,汤 健,等．牛磺酸对家兔心肌肌膜和磷脂脂质体脂质过氧化的影响．中国药理学通报 1991；7(5)：354.

［3］Obta H．Azama J．Awata N．et al．Mechanism of the protective action of taudne agnist isoprenaline induced myocardial damage．Cardiomvasc Res 1988；22(3)：407.

［4］Peterson MB．Mead RJ．Welty JD．et,al．Free amino acids in congestive heart faliure．J Md Cell Cardiol 1973；5：139.

［5］Takihara K，Azuma J．Awata N．et al．Beneficial effect of taurine in rabbits with chronic congestive heart failure．Am Heart J 1986；112：1278.

［6］黄金保,王国祥.牛磺酸对心血管的药理作用．中国药理学通报 1991；7(1)：8.

［7］Huxtable RJ．Physiological actions of taurine．Physiol Rev 1992；72(1)：101.

备注/Memo

备注/Memo:
Received 1994-08-04
更新日期/Last Update: 1995-05-01