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|本期目录/Table of Contents|

布吡卡因对豚鼠乳头肌动作电位的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
1996年第1期
页码:
10-13
栏目:
论著
出版日期:
1996-01-01

文章信息/Info

Title:
Effects of bupivacaine on nction potentials in guinea pig phpillary muscle
作者:
徐礼鲜1 赵德化2 刘亚南3
第四军医大学 1口腔医学院麻醉科 2药理学教研室 西安 710032 3西北国棉三厂职工医院内科
Author(s):
Xu Lixian1 Zhao Dehua2 Liu Yanan3
1Department of Anesthesiology，Stomatological Hospital；2Department of Pharmacology，Fourth Military Medical University，Xit an 710032 3Department of Internal Medicine，Staff Hospital，the Third Cotton Mill in Northwest China
关键词:
布吡卡因; 动作电位; 乳头状肌; 豚鼠
Keywords:
bupivacaine; action potentials; papillary muscles; guinea pigs
分类号:
-
DOI:
-
文献标识码:
-
摘要:
作者用玻璃微电极技术，研究了国产布吡卡因对豚鼠乳头状肌动作电位的影响。结果表明，布吡卡因在台氏液中浓度为5、10 pmol／L时，能明显降低动作电位幅度(APA)和O相最大除极速率(Vmax)；布吡卡因10 umol／L尚能缩短动作电位时程(APD50，PD90、APD100)，同时能相对延长有效不应期(ERP)，使ERP／APD比值增大。在高K+慢反应中，该药10 umol／L能降低APA和Vmax，并缩短APD50、APD90。说明布毗卡因能明显抑制心肌细胞Na+内流，同时对慢通道Ca2+内流也有一定的阻滞作用。提示布吡卡因用量合适，可产生抗心律失常效应。
Abstract:
The effects of bupivacaine on action potential and slow response action potentials in guinea pig papillary muscle were investigated by microelectrode technique,The experiment showed that bupivacaine(10 umol／L)could shorten action potential duration(APD50，APD90，APD100)，decrease the APA，Vmax and relatively prolong the effective refractory period(ERP).So ERP／APD became greater in guinea pig papillary．muscles．In slow response action potential，bupivacaine(10 umol／L)also reduced APA，Vmax and shorten APD50 and APD90．These results suggest that bupivacaine may inhibit the currents of Ca2+，Na+and have an antiarrhythmic effect．

参考文献/References

［1］Nath Tohansson G,Reiz S.Differential depressant and electrophysiologic cardiotoxicity of local anesthetics;An experumental study with special reference to lidocaine and bupivacaine.Anesth AAnaly 1986;65(9):1263.

［2］ Tanz RD，Heskett T，Loehning RW．et al．Comparative cardiotoxicity of bupivacaine and lidocaine in the isolated perfused mammalian heart．Anesth analy 1984；63(3)：549.

［3］ Charles W，Buffington MD．The magnitude and duration of direct myocardial depression following intracoronary local anesthetics：A comparison of lidocaine and bupivacaine．Anesthesiology 1989； 70(3)：280.

［4］ 王焱林，刘颖涛，万德宁，等．布吡卡因静脉注射对狗心肌电生理和血流动力学的影响．中华麻醉学杂志1989；9(4)：213.

［5］Wheeler DM，Bradley EL．Woods WT．The eleetrophsiologic actions of lidocaine and bupivacaine in The isolated perfused canine heart．Anesthesiology 1985；62(2)：298.

［6］Hauswirth O，sing BN．Ionic mechanisms in．heart muscle in relation to the genesis and the m phamcological control of cardiac arrhythmias．Phuarmacd 1978；30(1)：5.

备注/Memo

备注/Memo:
Received 1994-07-04；revised 1995-03-01
更新日期/Last Update: 1996-01-01