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体外反搏对冠心病患者内皮素及组织型纤溶酶原活性的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
1997年第4期
页码:
215-217
栏目:
论著
出版日期:
1997-08-01

文章信息/Info

Title:
Effect of external counter pulsation on plasma endothelin and tissue plasminogen activities in patients with coronary heart disease
作者:
王聪霞1　孙济川1　田清海1　丁抗宁1　张进虎2
1 西安医科大学第二附属医院心内科　西安 710004　2 陕西省人民医院
Author(s):
Wang Congxia1;  Sun Jichuan1;  Tian Qinghai1; Ding Kangning1;  Zhang Jinhu2
1Department of Cardiology, Second Affiliated Hospital, Xi′an Medical University, Xi′an 710004 2People′s Hospital of Shaanx i Province
关键词:
冠状动脉疾病　体外反搏　内皮素　纤溶酶原活性
Keywords:
coronary disease　　external counter pulsation 　　endothelins　　plasminogen activit ies
分类号:
-
DOI:
-
文献标识码:
-
摘要:
应用体外反搏(ECP)治疗40例冠心病患者, 按病情分为3组, 急性心肌梗死5例, 不稳定型心绞痛13例, 稳定型心绞痛22例。观察ECP前后内皮源性血管活性物质内皮素-1(ET-1)、组织型纤溶酶原激活物( t-PA) 及其抑制剂(PAI-1)的变化。结果显示: 反搏后ET-1含量、PAI-1 活性明显下降; t-PA 活性明显回升。提示ECP 治疗冠心病除血流动力学、血液流变学等因素外, 还可改变内皮源性血管活性物质的活性, 从而对ECP治疗冠心病的机理提出了新的观点。
Abstract:
40 patients with coronary heart disease treated by external counter pulsation(ECP) were divided into three groups: acute myocardial infarction (n=5),unstable angina pectoris(n=13),stable angina pectoris(n=22). Plasma endothelin-1 (ET-1),tissue-type plasminogen activator(t-PA) and plasm inogen activator inhibitor-1(PAI-1) were studied before and after ECP. The results showed that plasma ET-1 and PAI-1 decreased significantly while plasmat-PA increased obviously after ECP. It is indicated that ECP treated coronary heart disease through changing levels of endothelium-derived vasoactive substances besides hemodynamics and hemorrheology factors. So the new viewpoint is put forward about treating mechanisms of ECP for coronary heart disease.

参考文献/References

［1］Yanagisawa M , Kurihara H, Kimura S, et al. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature, 1988; 332(2) : 411 .

［2］Oseroff A , Krishnamurtic C, Hassett A , et al.Plasminogen activator and plasminogen activator inhibitor activities in men with coronary atrery disease. J Lab Clin Med , 1989; 113(1) : 88.

［3］Kern MJ , Henry RH,Lembo N , et al. Effects of pulsed external augmentation of diastolic pres sureon coronary and systemic hemodynamic in patients with coronary artery disease. Am Heart J , 1985; 110(3) : 727.

［4］Shetty SS,Okada T ,Webb RL, et al. Functionally distinct endothelin B receptor in vascular endothelium and smooth muscle. Biochem Biophys Res Commun, 1993; 19 (2) : 459 .

［5］Hamsten A,Wiman B,Faire U, et al.Increased plasma levels of arapid inhibitor of tissue plasminogen activator in young survivors of acute myocardial infarction. N Engl J Med , 1985;313 (4) : 1557 .

［6］Juban-Vague I,Alessic MC, Joly P, et al. Plasma plasminogen activator inhibitor-1 in angina pectoris: Influence of plasma insulin and acute-phase response. Arteriosclerosis,1989;9 (2):362.

备注/Memo

备注/Memo:
Received 1996-12-05
更新日期/Last Update: 1997-08-01