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《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:

1998年第1期

页码:

19-20

栏目:

论著

出版日期:

1998-01-01

文章信息/Info

Title:

VEGF expression and its relationship with AgNOR quantification in hepatic hemangioma

作者:

赵爱志　李开宗　窦科峰　付由池

第四军医大学西京医院肝胆外科 西安 710032

Author(s):

Zhao Aizhi; Li Kaizong ; Dou Kefeng ;  Fu Youchi

Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi′an 710032

关键词:

血管瘤;  肝　血管内皮生长因子　核仁组成区相关嗜银蛋白

Keywords:

hepatic hemangioma　VEGF　AgNOR

分类号:

-

DOI:

-

文献标识码:

-

摘要:

本文用肝血管瘤石蜡切片作血管内皮生长因子(VEGF) 链霉亲和素—生物素—过氧化物酶免疫组织化学染色(即SABC法) 和核仁组成区相关嗜银蛋白(AgNOR) 计数方法, 研究VEGF在肝血管瘤成因中的地位。结果显示: 48例肝血管瘤标本中,VEGF阳性表达率为75.0% ,其中(+ )者9例, (艹)者11例, (卅) 者16例, 且VEGF表达强度在不同的组别间AgNOR计数差异显著(P<0.01)。提示VEGF在肝血管瘤的成因中可能具有重要意义。

Abstract:

This experiment studies the role of Vascular Endothelial Growth Factor(VEGF) in the cause of hepatic hemangioma with Immunohistochemical staining (SABC) and AgNOR counting with paraffin-embedded hepatic hemangioma slides.The results showed that in the 48 cases of hepatic hemangioma, VEGF positive rate was 75.0% , with 9 cases (+ ) , 11cases (艹 ) , 16 cases (卅) , and the difference between groups of different degrees of VEGF expression was significant (P<0.01).The results tend to indicate that VEGF may have a lot to do with the cause of hepatic hemangioma.

参考文献/References

［1］Robert RL , Conter MD,William P, et al. Recurrent hepatic hemangiomas.Ann Surg , 1988; 207: 115.

［2］Wizigmann-voos S, Breier G, Risau W , et al.Up-regulation of vascular endothelial growth factor and its receptors in von Hippel-Lindau Disease-associated and sporadic hemangioblastomas.Cancer Res. 1995; 55:1358.

［3］Ladoux A , Frekkn C.Hypoxia is a strong inducer of vascular endothelial growth factor mRNA expression in the heart.Biochem Biophys Res Commun, 1993; 195: 1005.

备注/Memo

备注/Memo:

(收稿1997-07-12)

常用功能

更新日期/Last Update: 1998-01-01