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|本期目录/Table of Contents|

链激酶溶栓治疗急性心肌梗死对左心室功能的改善作用(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
1998年第3期
页码:
151-153
栏目:
论著
出版日期:
1998-05-01

文章信息/Info

Title:
Effect of streptokinase thrombolytic reperfusion on left ventricular function after acute myocardial infarction
作者:
汪 涛1 吴宗贵2
1济南军区青岛第一疗养院三科　青岛 266071　2第二军医大学长征医院心内科
Author(s):
Wang Tao1;  Wu Zhonggui2
1Qingdao First Sanatorium of Jinan Command Area, Qingdao 266071　2Department of Cardiology, Changzheng Hospital, Second Military Medical University, Shanghai 200003
关键词:
心肌梗死　链激酶　溶栓疗法　心室功能;  左
Keywords:
myocardial infarction 　streptokinase　thrombolytic therapy　ventricular function; left
分类号:
-
DOI:
-
文献标识码:
-
摘要:
为评价链激酶溶栓治疗急性心肌梗死(AMI) 对左心室功能的影响, 应用二维超声心动图对26例接受链激酶溶栓治疗的AMI患者和27例未溶栓的AMI患者, 分别在急性期及6个月后随访时测量并计算左心室容积(EDV 和ESV ) , 射血分数(EF) 以及室壁运动指数(GWMI和RWMI)。以上各项指标在急性期时比较各组无显著性差异; 在随访期再通组EF 值明显高于未通组和未溶栓组, 再通组左室容量减小。急性期各组心功能无差异, 随访时再通组心功能较未通组显著改善。提示: 链激酶溶栓能明显减轻AMI患者的左心室扩张, 改善左心室功能和长期预后。
Abstract:
The aim of this study was to assess the effects of streptokinase thrombolytic reperfusion on left ventricular size and function evaluated by two-dimensional echocardiography. Twenty-six patients with first acute myocardial infarction (AMI) receiving thrombolytic therapy were divided into reperfusion group and non-reperfusion group acording to the clinical characteristics.Twenty-seven cases with AMI not receiving thrombolytic therapy was unthrombolysis group.Left ventricular end-diastolic volume(EDV) , end-systolic volume (ESV) , and ejection fraction (EF) were determined by Sipson biplane formula. Global and regional wall motion score indices(GWMI and RWMI) were also analyzed. There was no significant difference in all the parameters among those groups during AMI period. During 6month′s follow-up , all parameters, except EF,were higher in the non-reperfusion group and the unthrombolysis group than those in the reperfusion group (P < 0.01 for all). EF in the reperfusion group was significantly improved during follow-up and was higher than that in the non-reperfusion (P <0.01). The result suggest that reperfusion with thrombolysis after AMI can prevent left ventricular dilatation. It can also improve heart function and prognosis.

参考文献/References

［1］陈国伟, 郑宗鄂.现代心脏内科学.长沙: 湖南科学技术出版社, 1995: 926～ 980.

［2］ISIS2. Randomized trial of intravenous streptokinase, oral aspirin, both, or neither among 17187 cases of suspected acute myocardial infarction. Lancet, 1988; 2: 239.

［3］White HD, shearpe N. Left ventricular endsystolic volume as the major determinant of survival after recovery from myocardial infarction. Circulation, 1987; 76 (1) : 44.

［4］Carstensen S. Effects of early enalapril treatment on global and regional wall motion in acute myocardial infarction. Am Heart J , 1995; 129: 1101.

［5］Shearpe N , White HD, Matsujak M. Late reversal of left ventricular dysfunction following myocardial infarction [abstract].Circulation, 1989; 80 (Suppl Ⅱ ) : Ⅱ 2253.

［6］李文华, 张金枝.急性心肌梗塞后左室重构及血管紧张素转换酶抑制剂对其影响.临床心血管病杂志, 1997; 13 (4) : 253.

备注/Memo

备注/Memo:
(收稿1997-11-21　修回1998-03-27)
更新日期/Last Update: 1998-05-01