CGRP对呼吸窘迫综合征家兔血浆内皮素含量及肺循环血流动力学的影响(PDF)
《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]
- 期数:
- 1999年第1期
- 页码:
- 18-19
- 栏目:
- 论著
- 出版日期:
- 1999-01-01
文章信息/Info
- Title:
- Effect of CGRP on endothelim content of plasma RDS rabbits and pulmonary hemodynamics
- 作者:
- 李金玲1 张 犁1 敖德英1 支东学1 王卫平1 周永红2
- 1解放军兰州医学高等专科学校生理学教研室 兰州 730020 2甘肃省军区五泉山干休所卫生所
- Author(s):
- Li Jinling1 ; Zhang Li1; Ao Deying1; Zhi Dongxue1; Wang Weiping1; Zhou Youhong2
- Lanzhou Medical college of PLA ,Lanzhou 730020
- 分类号:
- -
- DOI:
- -
- 文献标识码:
- -
- 摘要:
- 用降钙素基因相关肽(CGRP)防治急性肺损伤, 观察CGRP对血浆内皮素(ET)含量的影响。结果表明: 应用CGRP组血浆内皮素含量较呼吸窘迫综合征组降低了(38±8)% (P<0.01),mPAP,RVP分别降低了(18±3)%和(25±4)% (P<0.05)。提示CGRP降低肺动脉压的作用可能与降低血浆内皮素水平有关; CGRP对急性肺损伤有一定的保护作用。
- Abstract:
- CGRP was used to prerent and cure acute lung injury and the effect of CGRP on endothelin content in plasma was observed. The results showed:After using CGRP, the endothelin content in plasma was reduced (38±8)% (P<0.01) mPAP, and RVP were reduced (18±3)% , (25±4)% (P<0.05) , respectively as compared with those of the RDS group. The result might suggest that the function of reducing pulmonary pressure is closely related to the reduce endothelin level, and that CGRP has a certain protective effect on acute lung injury.
参考文献/References
［1］Skofitsch G, Jatobwitc DM. Quantitative distribution of calcitonin gene-related peptide in rat central nervous system. Peptid es, 1985; 6: 1069.
［2］Ram Z, Saden M , Shacked I, et al. Magnesium sulfate reverses experimental delayed cerebral vasospasm after subarachnoid hemorrhage in rats. Stroke, 1991; 22: 922.
［3］倪 慧,张尚检,张日新,等.家兔油酸型急性呼吸窘迫综合征时肺动脉压的变化.生理学报,1986;38 (3):293.
［4］孙 波, 刘文利.右心导管测定大鼠肺动脉压的实验方法.中国医学科学院学报, 1984; (6) : 465 .
［5］Brain SD,Williams TJ,Tippins, et al. Calcitonin gene related peptide is a potent vasodilator. Nature, 1985; 313 (1) : 125.
［6］汤 键, 唐朝枢, 编著,循环系统的内分泌功能,北京: 北京医科大学.中国协和医科大学联合出版社, 1989: 121-131.
备注/Memo
- 备注/Memo:
- (收稿1998-03-10 修回1998-11-02)
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更新日期/Last Update: 1999-01-01